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Acknowledgements

We gratefully acknowledge the generosity of Dr. F. Miragall (Institut für Anatomie, Universität Regensburg, Regensburg, Germany) for the antibodies to PSA-NCAM and NCAM. We also thank M. March for her excellent technical assistance. This study was supported by CICYT grant SAF 96-0185-CO2-02, DGESIC grant PM 97-0075-CO2, Generalitat Valenciana grant GV-D-VS-20-126-96, and Fundacion R. Areces.

  • 1
    Barthels D., Vopper G., Wille W. (1988) N-CAM-180, the large isoform of the neural cell adhesion molecule of the mouse, is encoded by an alternatively spliced transcript.Nucleic Acids Res. 16 42174225.
  • 2
    Bearer C.F., Swick A.R., O'Riordan M.A., Cheng G. (1999) Ethanol inhibits L1-mediated neurite outgrowth in postnatal rat cerebellar granule cells.J. Biol. Chem. 274 1326413270.
  • 3
    Breen K.C., Kelly P.G., Regan C.M. (1987) Postnatal D2-CAM/N-CAM sialylation state is controlled by a developmentally regulated Golgi sialyltransferase.J. Neurochem. 48 14861493.
  • 4
    Breen K.C., Coughlan C.M., Hayes F.D. (1998) The role of glycoproteins in neural development, function, and disease.Mol. Neurobiol. 16 159.
  • 5
    Bruses J.L. & Ruthishauser U. (1998) Regulation of neural cell adhesion molecule polysialylation. Evidence for nontranscriptional control and sensitivity to an intracellular pool of calcium.J. Cell Biol. 140 11771186.
  • 6
    Catlin M.C., Guizzeti M., Costa L.G. (1998) Effects of ethanol on calcium homeostasis in the nervous system.Mol. Neurobiol. 19 124.
  • 7
    Charness M.E., Safran R.M., Perides G. (1994) Ethanol inhibits neural cell—cell adhesion. J. Biol. Chem. 269 93049309.
  • 8
    Chomczynski P. & Sacchi N. (1987) Single step method of RNA isolation by acid guanidinium thiocyanate—phenol—chloroform extraction. Anal. Biochem. 162 156159.
  • 9
    Chuong C.M. & Edelman G.M. (1984) Alterations in neural cell adhesion molecules during development of different regions of the nervous system.J. Neurosci. 4 23542368.
  • 10
    Cookman G.R., King W., Regan C.K. (1987) Chronic low-level lead exposure impairs embryonic to adult conversion of the neural cell adhesion molecule.J. Neurochem. 49 399403.
  • 11
    Cremer H., Lange R., Christoph A., Plomann M., Vopper G., Roes J., Brown R., Baldwin S., Kraemer P., Scheff S., Barthels D., Rajewsky K., Wille W. (1994) Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning.Nature 367 455459.
  • 12
    Danielson P.E., Forss-Petter S., Brow M.A., Calavetta L., Douglass J., Milner R.J., Sutcliffe J.G. (1988) p1B15: a cDNA clone of the rat mRNA encoding cyclophilin.DNA 7 261267.
  • 13
    Easton E.W., Schiphorst W.E.C.M., Koeleman C.A.M., Michalides R.J.A.M., Van Den Eijnden D.H. (1995) CMP-NeuAc: (NeuAcα2 8)n (colominic acid) sialyltransferase activity in rat brain and in tumour cells that express polysialic acid on neural cell adhesion molecules.Glycoconj. J. 12 829837.
  • 14
    Eckhardt M., Mülenhoff M., Bethe A., Koopman J., Frosch M., Gerardy-Schachn R. (1995) Molecular characterization of eukaryotic polysialytransferase-1.Nature 373 715718.
  • 15
    Edelman G. & Chuong C. (1982) Embryonic to adult conversion of neural cell adhesion molecule in normal and staggerer mice.Proc. Natl. Acad. Sci. USA 79 70367040.
  • 16
    Edelman G.M. & Crossin K.L. (1991) Cell adhesion molecules: implications for molecular histology.Annu. Rev. Biochem. 60 155190.
  • 17
    Fields R.D. & Itoh K. (1996) Neural cell adhesion molecules in activity-dependent development and in synaptic plasticity.Trends Neurosci. 19 473480.
  • 18
    Gennarini G., Hirsch M.R., Hai-Tao H., Hirn M., Finne J., Goridis C. (1986) Differential expression of mouse neural cell adhesion molecule (N-CAM) mRNA species during brain development in neural cell lines.J. Neurosci. 6 19831990.
  • 19
    Ghosh P., Ender I., Hale E.A. (1998) Long-term ethanol consumption selectively impairs ganglioside pathway in rat brain.Alcohol. Clin. Exp. Res. 22 12201226.
  • 20
    Guerri C. (1987) Synaptic membrane alterations in rats exposed to alcohol.Alcohol Alcohol. Suppl. 1 467472.
  • 21
    Guerri C. & Renau-Piqueras J. (1997) Alcohol, astroglia, and brain development.Mol. Neurobiol. 15 6581.
  • 22
    Guerri C. & Sanchis R. (1985) Acetaldehyde and alcohol levels in pregnant rats and their fetuses.Alcohol 2 267270.
  • 23
    Guerri C., Saez R., Sancho-Tello M., Mart́in de Aguilera E., Renau-Piqueras J. (1990) Ethanol alters astrocyte development: a study of critical periods using primary cultures.Neurochem. Res. 15 559565.
  • 24
    Guasch R., Renau-Piqueras J., Guerri C. (1992) Chronic ethanol consumption induces accumulation of proteins in the liver Golgi apparatus and decreases galactosyltransferase activity.Alcohol. Clin. Exp. Res. 16 942948.
  • 25
    Hale E.A., Raza K.R., Ciecierski R.G., Ghosh P. (1998) Deleterious actions of chronic ethanol treatment on the glycosylation of rat brain clustering.Brain Res. 785 158166.
  • 26
    Hildebrandt H., Becker C., Mürau M., Gerardy-Schachn R., Rahmann H. (1998) Heterogeneous expression of the polysialytransferases ST8Sia II and ST8Sia IV during postnatal rat brain development.J. Neurochem. 71 23392348.
  • 27
    Horstkorte R., Schachner M., Magyar J.P., Vorherr T., Schmitz B. (1993) The fourth immunoglobulin-like domain of NCAM contains a carbohydrate recognition domain for oligomannosidic glycans implicated in association with L1 and neurite outgrowth.J. Cell Biol. 121 14091421.
  • 28
    Iborra F.J., Renau-Piqueras J., Portoles M., Boleda M.D., Guerri C., Parés X. (1992) Immunocytochemical and biochemical demonstration of formaldehyde dehydrogenase (class III alcohol dehydrogenase) in the nucleus.J. Histochem. Cytochem. 40 18651878.
  • 29
    Ibsen S., Berezin V., Nørgaard-Pedersen B., Bock E. (1983) Quantification of the D2-glycoprotein in amniotic fluid and serum from pregnancies with fetal neural tube defects.J. Neurochem. 41 363366.
  • 30
    Inomata K., Nasu F., Tanaka H. (1987) Decreased density of synaptic formation in the frontal cortex of neonatal rats exposed to ethanol in utero. Int. J. Dev. Neurosci. 5 455460.
  • 31
    Kentroty S., Rahman H., Grove J., Vernardakis A. (1995) Ethanol neurotoxicity in the embryonic chick brain in ovo and in culture: interaction of the neural cell adhesion molecule (NCAM).Int. J. Dev. Neurosci. 13 859870.
  • 32
    Kiss J. & Rougon G. (1997) Cell biology of polysialic acid.Curr. Opin. Neurobiol. 7 640646.
  • 33
    Kiss J.Z., Wang C, Olive S., Rougon G., Lang J., Baetens D., Harry D., Pralong W. -F. (1994) Activity-dependent mobilization of the adhesion molecule polysialic NCAM to the cell surface of neurons and endocrine cells.EMBO J. 13 52845292.
  • 34
    Kojima N., Yoshida Y., Kurosawa N., Lee Y., Tsuji S. (1995) Enzymatic activity of a developmentally regulated member of the sialyltransferase family (STX): evidence forα2,8-sialyltransferase activity toward N-linked oligosaccharides. FEBS Lett. 360 14.
  • 35
    Laemmli U.K. (1970) Cleavage of structural proteins during the assembly of the head of the bacteriophage T4.Nature 227 680685.
  • 36
    Lieber C.S. & DeCarli L.M. (1994) Animal models of chronic ethanol toxicity.Methods Enzymol. 233 585594.
  • 37
    Megías L., Guerri C., Fornás E., Azorín I., Bendala E., Sancho-Tello M., Durán J.M., Tomás M., Gomez-Lechón M.J., Renau-Piqueras J. (2000) Endocytosis and transcytosis in growing astrocytes in primary culture. Possible implications in neural development.Int. J. Dev. Biol. 44 209221.
  • 38
    Miller M.W. (1992) The effects of prenatal exposure to ethanol on cell proliferation and neuronal migration, inDevelopment of the Central Nervous System: Effects of Alcohol and Opiates (Miller M., ed), pp. 4769. Alan R. Liss, New York.
  • 39
    Miñana R., Sancho-Tello M., Climent E., Seguí J.M., Renau-Piqueras J., Guerri C. (1998) Intracellular location, temporal expression, and polysialylation of neural cell adhesion molecule in astrocytes in primary culture.Glia 24 415427.
  • 40
    Miragall F., Kadmon G., Faissner A., Antonicek H., Schachner M. (1990) Retention of J1/tenascin and the polysialylated form of the neural cell adhesion molecule (N-CAM) in the adult olfactory bulb.J. Neurocytol. 19 899914.
  • 41
    Murphy K.J. & Regan C.M. (1999) Low-level lead exposure in the early postnatal period results in persisting neuroplastic deficits associated with memory consolidation.J. Neurochem. 72 20992104.
  • 42
    Nagata I. & Schachner M. (1986) Conversion of embryonic to adult form of the neural cell adhesion molecule (NCAM) does not correlate with pre- and postmigratory states of mouse cerebellum granule neurons.Neurosci. Lett. 63 153158.
  • 43
    Persohn E. & Schachner M. (1987) Immunoelectron microscopic localization of the neural cell adhesion molecules L1 and N-CAM during postnatal development of the mouse cerebellum.J. Cell Biol. 105 569576.
  • 44
    Renau-Piqueras J., Zaragozá R., De Paz P., Báguena-Cervellera R., Megias L., Guerri C. (1989a) Effects of prolonged ethanol exposure on the glial fibrillary acidic protein-containing intermediate filaments of astrocytes in primary culture: a quantitative immunofluorescence and immunogold electron microscopic study.J. Histochem. Cytochem. 37 229240.
  • 45
    Renau-Piqueras J., Sancho-Tello M., Báguena-Cervellera R., Guerri C. (1989b) Prenatal exposure to ethanol alters the synthesis and glycosylation of proteins in fetal hepatocytes.Alcohol. Clin. Exp. Res. 13 813823.
  • 46
    Renau-Piqueras J., Guerri C., Burgal M., De Paz P., Saez R., Mayordomo F. (1992) Prenatal exposure to ethanol alters plasma membrane glycoproteins of astrocytes during development in primary culture as revealed by concanavalin A binding and 5-nucleotidase activity.Glia 5 6574.
  • 47
    Renau-Piqueras J., Guasch R., Azoŕin I., Seguí J., Guerri C. (1997) Prenatal alcohol exposure affects galactosyltransferase activity and glycoconjugates in the Golgi apparatus of fetal rat hepatocytes.Hepatology 25 343350.
  • 48
    Rothbard J.B., Brackenbury R., Cunningham B.A., Edelman G.M. (1982) Differences in the carbohydrate structures of neural cell-adhesion molecules from adult and embryonic chicken brains.J. Biol. Chem. 257 1106411069.
  • 49
    Rutishauser U. (1996) Polysialic acid and the regulation of cell interactions.Curr. Opin. Cell Biol. 8 679684.
  • 50
    Sadoul R., Hirn M., Deagostini-Bazin H., Rougon G., Goridis C. (1983) Adult and embronic mouse neural cell adhesion molecules have different binding properties.Nature 304 347349.
  • 51
    Sanchis R., Sancho-Tello M., Guerri C. (1986) The effects of chronic alcohol consumption on pregnant rats and their offspring.Alcohol Alcohol. 21 295305.
  • 52
    Scheidegger P., Papay J., Zuber C, Lackie P.M., Roth J. (1994) Cellular site of synthesis and dynamics of cell surface re-expression of polysialic acid of the neural cell adhesion molecule.Eur. J. Biochem. 225 10971103.
  • 53
    Small S.J., Shull G.E., Santoni M.J., Akeson R. (1987) Identification of a cDNA clone that contains the complete coding sequence for a 140-kD rat NCAM polypeptide.J. Cell Biol. 105 23352345.
  • 54
    Streissguth A.P., Barr H.M., Carmichael Olson H., Sampson P.D., Bookstein F.L., Burges D.M. (1994) Drinking during pregnancy decreases word attack and arithmetic scores on standardized test: adolescent data from a population-based prospective study.Alcohol. Clin. Exp. Res. 18 248254.
  • 55
    Sunshine J., Balak K., Rutishauser U., Jacobson M. (1987) Changes in neural cell adhesion molecule (NCAM) structure during vertebrate neural development.Proc. Natl. Acad. Sci. USA 84 59865990.
  • 56
    Toikka J., Aalto J., Häyrinen J., Pelliniemi L.J., Finne J. (1998) The polysialic acid units of the neural cell adhesion molecule N-CAM form filament bundle networks.J. Biol. Chem. 273 2855728559.
  • 57
    Tomasiewicz H., Ono K., Yee D., Thompson C., Goridis C., Rutishauser U., Magnuson T. (1993) Genetic deletion of a neural cell adhesion molecule variant (N-CAM-180) produces distinct defects in the central nervous system.Neuron 11 11631174.
  • 58
    Tuma D.J., Casey C.A., Sorrell M.F. (1991) Chronic ethanol-induced impairments in receptor-mediated endocytosis of insulin in rat hepatocytes.Alcohol. Clin. Exp. Res. 15 808813.
  • 59
    Tuma D.J., Todero S.L., Barak-Bernhagen M., Sorrell M.F. (1996) Effects of chronic ethanol administration on the endocytosis of cytokines by rat hepatocytes.Alcohol. Clin. Exp. Res. 20 579583.
  • 60
    Vallés S., Lindo L., Montoliu C., Renau-Piqueras J., Guerri C. (1994) Prenatal exposure to ethanol induces changes in the nerve growth factor and its receptor in proliferating astrocytes in primary culture.Brain Res. 656 281286.
  • 61
    Vallés S., Sancho-Tello M., Miñana R., Climent E., Renau-Piqueras J., Guerri C. (1996) Glial fibrillary acidic protein expression in rat brain and in radial glia culture is delayed by prenatal ethanol exposure.J. Neurochem. 67 24252433.
  • 62
    Vallés S., Pitarch J., Renau-Piqueras J., Guerri C. (1997) Ethanol exposure affects glial fibrillary acidic protein gene expression and transcription during rat brain development.J. Neurochem. 69 24842493.
  • 63
    Warren L. (1959) The thiobarbituric acid assay of sialic acids.J. Biol. Chem. 234 19711975.