• 1
    Berman K.F. & Weinberger D.R. (1991) Prefrontal dopamine and defect symptoms in schizophrenia, inNegative Schizophrenic Symptoms: Pathophysiology and Clinical Implications (Greden J. F. and Tandon R., eds), pp. 8395. American Psychiatric Press, Washington, D.C.
  • 2
    Bowers M.B. & Rozitis A. (1974) Regional differences in homovanillic acid concentrations after acute and chronic administration of antipsychotic drugs.J. Pharm. Pharmacol. 26 743745.
  • 3
    Burki H.R., Ruch W., Asper H. (1975) Effects of clozapine, thioridazine, perpaline and haloperidol on the metabolism of the biogenic amines in the brain of the rat.Psychopharmacologia 41 2733.
  • 4
    Cartmell J., Monn J.A., Schoepp D.D. (1999) The mGlu2/3 receptor agonists, LY354740 and LY379268, selectively attenuate phencyclidine versus d-amphetamine motor behaviors in rats. J. Pharmacol. Exp. Ther. 291 161170.
  • 5
    Commissiong J.W. (1985) Monoamine metabolites: their relationship and lack of relationship to monoaminergic neuronal activity.Biochem. Pharmacol. 34 11271131.
  • 6
    Conn P.J. & Pin J. -P. (1997) Pharmacology and functions of metabotropic glutamate receptors.Annu. Rev. Pharmacol. Toxicol. 37 205237.
  • 7
    Elsworth J.D., Leahy D.J., Roth R.H., Redmond D.E. (1987) Homovanillic acid concentrations in brain, CSF and plasma as indicators of central dopamine function in primates.J. Neural Transm. 68 5162.
  • 8
    Hertel P., Nomikos G.G., Iurlo M., Svensson T.H. (1996) Risperidone: regional effects in vivo on release and metabolism of dopamine and serotonin in the rat brain.Psychopharmacology (Berl.) 124 7486.
  • 9
    Hertel P., Nomikos G.G., Schilstrom B., Arborelius L., Svensson T.H. (1997) Risperidone dose-dependently increases extracellular concentrations of serotonin in the rat frontal cortex: role of α2-adrenoceptor antagonism. Neuropsychopharmacology 17 4455.
  • 10
    Imperato A. & Angelucci L. (1989) The effects of clozapine and fluperlapine on the in vivo release and metabolism of dopamine in the striatum and in the prefrontal cortex of the freely moving rat.Psychopharmacol. Bull. 25 383389.
  • 11
    Ingvar D.H. & Franzen G. (1974) Abnormalities of cerebral blood flow distribution in patients with chronic schizophrenia.Acta Psychiatr. Scand. 50 425462.
  • 12
    Kingston A.E., Ornstein P.L., Wright R.A., Johnson B.G., Mayne N.G., Burnett J.P., Belagaje R., Wu S., Schoepp D.D. (1998) LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors.Neuropharmacology 37 112.
  • 13
    Li X., Perry K.W., Wong D.T., Bymaster F.P. (1998) Olanzapine increases in vivo dopamine and norepinephrine release in rat prefrontal cortex, nucleus accumbens and striatum.Psychopharmacology (Berl.) 136 153161.
  • 14
    Lindstrom L.H. (1985) Low HVA and normal 5HIAA CSF levels in drug-free schizophrenic patients compared to healthy volunteers: correlations to symptomatology and family history.Psychiatry Res. 14 265273.
  • 15
    Lindstrom E. & Von Knorring L. (1994) Changes in single symptoms and separate factors of the schizophrenic syndrome after treatment with risperidone or haloperidol.Pharmacopsychiatry 27 108113.
  • 16
    Moghaddam B. & Adams B.K. (1998) Reversal of phencyclidine effects by a group II metabotropic receptor agonist in rats.Science 281 13491351.
  • 17
    Monn J.A., Valli M.J., Massey S.M., Wright R.A., Salhoff C.R., Johnson B.G., Howe T., Alt C.A., Rhodes G.A., Robey R.L., Griffey K.R., Tizzano J.P., Kallman M.J., Helton D.R., Schoepp D.D. (1997) Design, synthesis and pharmacological characterization of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: a potent, selective, systematically active group 2 metabotropic glutamate receptor agonist possessing anticonvulsant and anxiolytic properties.J. Med. Chem. 40 528537.
  • 18
    Monn J.A., Valli M.J., Massey S.M., Hansen M.M., Kress T.J., Wepsiec J.P., Grutsch J.L., Wright R.A., Johnson B.G., Andis S.L., Kingston A.E., Tomlinson R., Lewis R., Griffey K.R., Tizzano J.P., Schoepp D.D. (1999) Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740): identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptors.J. Med. Chem. 42 10271040.
  • 19
    Nabeshima T., Yamada K., Yamaguchi K., Hiramatsu M., Furukawa H., Kameyama T. (1983a) Effect of lesions in the striatum, nucleus accumbens and medial raphe on phencyclidine-induced stereotyped behaviors and hyperactivity in rats.Eur. J. Pharmacol. 91 455462.
  • 20
    Nabeshima T., Yamaguchi K., Yamada K., Hiramatsu M., Furukawa H., Kameyama T. (1983b) Phencyclidine-induced stereotyped behaviors in rats following specific neurotoxin lesions of the striatum.Eur. J. Pharmacol. 93 229234.
  • 21
    Nomikos G.G., Iurlo M., Andersson J.L., Kimura K., Svensson T.H. (1994) Systemic administration of amperozide, a new atypical antipsychotic drug, preferentially increases dopamine release in the rat medial prefrontal cortex.Psychopharmacology (Berl.) 115 147156.
  • 22
    Perry K.W. (1999) Effect of a tetrodotoxin pulse on dopamine and serotonin synthesis and metabolism in rat striatum as determined by microdialysis.Proceedings of the 8th International Conference on In Vivo Methods, New York, June 19-23, 1999, p. 244.
  • 23
    Perry K.W. & Fuller R.W. (1992) Effect of fluoxetine on serotonin and dopamine concentration in microdialysis fluid from rat striatum.Life Sci. 50 16831690.
  • 24
    Pin J., De Colle C., Bessis A., Archer F. (1999) New perspectives for the development of selective metabotropic glutamate receptor ligands.Eur. J. Pharmacol. 375 277294.
  • 25
    Ruch W., Asper H., Burki H.R. (1976) Effect of clozapine on the metabolism of serotonin in rat brain.Psychopharmacologia 46 103109.
  • 26
    Schoepp D.D., Jane D.E., Monn J.A. (1999) Pharmacological agents acting at subtypes of metabotropic glutamate receptors.Neuropharmacology 38 14311476.
  • 27
    Volonté M., Monferini E., Cerutti M., Fodritto F., Borsini F. (1997) BIMG 80, a novel potential antipsychotic drug: evidence for multireceptor actions and preferential release of dopamine in prefrontal cortex.J. Neurochem. 69 182190.
  • 28
    Weinberger D.R. (1988) Schizophrenia and the frontal lobe.Trends Neurosci. 11 367370.
  • 29
    Westerink B.H.C. (1985) Sequence and significance of dopamine metabolism in the rat brain.Neurochem. Int. 7 221227.
  • 30
    Yamamoto B.K., Pehek E.A., Meltzer H.Y. (1994) Brain region effects of clozapine on amino acid and monoamine transmission.J. Clin. Psychiatry 55 (Suppl. B) , 814.