The authors' research is supported by the National Institute of Mental Health (RO1-MH57743, RO1-MH 59107), Theodore and Vada Stanley Foundation, NARSAD, and Joseph Young Sr. research grants. The authors thank Gregory Kapatos for his very thoughtful critique of the manuscript and P. S. Goldman-Rakic, Ph.D., and P. Rakic, Ph.D., from Yale University School of Medicine for sharing software for three-dimensional cell counting. Outstanding technical assistance was provided by Li-Dong Huang.

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