We thank D. Leszkiewicz, S. Du, and M. Tran for suggestions and help with some of the experiments and Dr. P. Land for many helpful discussions. This work was supported by grants NS29365 (to E.A.) and NS34138 (to I.J.R.) from the National Institutes of Health, a Grant-in Aid from the American Heart Association (to E.A.), grant 98292027 (to I.J.R.) from the USAMRMC, and the University of Pittsburgh Alzheimer's Disease Research Center (to B.A.M.). I.J.R. is an Established Investigator of the American Heart Association.

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