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Acknowledgements

We are very grateful to Lotta Johanson for secretarial help, Annika Ahlsen and Maite Muñoz for technical assistance, and Anna Bosch for her support and advice in the use of confocal microscopy. Financial support was obtained from the BIOMED2 Program of the European Commission (grant BMH4-CT96-0273), CICYT (grants SAF96-0043 and SAF99-0019, Ministerio de Educación y Ciencia, Spain), La Marató de TV3 (grant 97-TV1009), the Swedish Medical Research Council (MFR, grant K98-12X-11563-03A), the Karolinska Institute, and the Jeanssonska and the Kapten Arthur Eriksson Foundations. E.P.-N. was a fellow of the European Molecular Biology Organization.

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