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Acknowledgements

We thank the Deutsche Forschungsgemeinschaft for continuing support of ourresearch on TGF-βs.

  • 1
    Abe K., Chu P.J., Ishihara A., Saito H. (1996) Transforming growth factor-beta 1 promotes re-elongation of injured axons of cultured rat hippocampal neurons.Brain Res. 723206209.
  • 2
    Aderka D., Le J.M., Vilcek J. (1989) IL-6 inhibits lipopolysaccharide-induced tumor necrosis factor production in cultured human monocytes, U937 cells, and in mice.J. Immunol. 14335173523.
  • 3
    Archer S.J., Bax A., Roberts A.B., Sporn M.B., Ogawa Y., Piez K.A., Weatherbee A., Tsang M.L., Lucas R., Zheng B.L., Wenker J., Torchia D.A. (1993) Transforming growth factor beta 1: secondary structure as determined by heteronuclear magnetic resonance spectroscopy.Biochemistry 3211641171.
  • 4
    Attisano L., Wrana J.L., Montalvo E., Massague J. (1996) Activation of signalling by the activin receptor complex.Mol. Cell. Biol. 1610661073.
  • 5
    Baghdassarian D., Toru-Delbauffe D., Gavaret J.M., Pierre M. (1993) Effects of transforming growth factor-β1 on the extracellular matrix and cytoskeleton of cultured astrocytes. Gila 7193202.
  • 6
    Baloh R.H., Tansey M.G., Lampe P.A., Fahrner T.J., Enomoto H., Simburger K.S., Leitner M.L., Araki T., Johnson E.M.J, Milbrandt J. (1998) Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex.Neuron 2112911302.
  • 7
    Barnum S.R. & Jones J.L. (1994) Transforming growth factor-beta 1 inhibits inflammatory cytokine-induced C3 gene expression in astrocytes.J. Immunol. 152765773.
  • 8
    Benveniste E.N., Kwon J., Chung W.J., Sampson J., Pandya K., Tang L.P. (1994) Differential modulation of astrocyte cytokine gene expression by TGF-beta.J. Immunol. 15352105221.
  • 9
    Benveniste E.N., Tang L.P., Law R.M. (1995) Differential regulation of astrocyte TNF-alpha expression by the cytokines TGF-beta, IL-6 and IL-10.Int. J. Dev. Neurosci. 13341349.
  • 10
    Blanchard M.G. & Josso N. (1974) Source of the anti-Mullerian hormone synthesized by the fetal testis: Mullerian-inhibiting activity of fetal bovine Sertoli cells in tissue culture.Pediatr. Res. 8968971.
  • 11
    Böttner M., Unsicker K., Suter-Crazzolara C. (1996) Expression of TGF-β type II receptor mRNA in the CNS.Neuroreport 729032907.
  • 12
    Brauer P.R. & Yee J.A. (1993) Cranial neural crest cells synthesize and secrete a latent form of transforming growth factor beta that can be activated by neural crest cell proteolysis.Dev. Biol. 155281285.
  • 13
    Burt D.W. & Law A.S. (1994) Evolution of the transforming growth factor-beta superfamily.Prog. Growth Factor Res. 599118.
  • 14
    Burt D.W. & Paton I.R. (1992) Evolutionary origins of the transforming growth factor-beta gene family.DNA Cell Biol. 11497510.
  • 15
    Cameron J.S., Lhuillier L., Subramony P., Dryer S.E. (1998) Developmental regulation of neuronal K+ channels by target-derived TGF beta in vivo and in vitro.Neuron 2110451053.
  • 16
    Cameron J.S., Dryer L., Dryer S.E. (1999) Regulation of neuronal K+ currents by target-derived factors: opposing actions of two different isoforms of TGFbeta.Development 12641574164.
  • 17
    Capdevila J. & Belmonte J.C. (1999) Extracellular modulation of the Hedgehog, Wnt and TGF-beta signalling pathways during embryonic development.Curr. Opin. Genet. Dev. 9427433.
  • 18
    Chalazonitis A., Kalberg J., Twardzik D.R., Morrison R.S., Kessler J.A. (1992) Transforming growth factor beta has neurotrophic actions on sensory neurons in vitro and synergistic with nerve growth factor.Dev. Biol. 152121132.
  • 19
    Chao C.C., Hu S., Sheng W.S., Tsang M., Peterson P.K. (1995a) Tumor necrosis factor-alpha mediates the release of bioactive transforming growth factor-beta in murine microglial cell cultures.Clin. Immunol. Immunopathol. 77358365.
  • 20
    Chao C.C., Hu S., Sheng W.S., Peterson P.K. (1995b) Tumor necrosis factor-alpha production by human fetal microglial cells: regulation by other cytokines.Dev. Neurosci. 1797105.
  • 21
    Chao C.C., Hu S., Peterson P.K. (1995c) Modulation of human microglial cell superoxide production by cytokines.J. Leukoc. Biol. 586570.
  • 22
    Cheifetz S., Bellon T., Cales C., Vera S., Bernabeu C., Massague J., Letarte M. (1992) Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells.J. Biol. Chem. 2671902719030.
  • 23
    Chen X., Weisberg E., Fridmacher V., Watanabe M., Naco J., Whitman M. (1997) Smad4 and FAST-1 in the assembly of activin-responsive factor.Nature 3898589.
  • 24
    Chen Y., Lebrun J.J., Vale W. (1996) Regulation of transforming growth factor beta- and activin-induced transcription by mammalian Mad proteins.Proc. Natl. Acad. Sci. USA 931299212997.
  • 25
    Colavita A., Krishna S., Zheng H., Padgett R.W., Culotti J.G. (1998) Pioneer axon guidance by UNC-129, a C. elegans TGF-beta.Science 281706709.
  • 26
    Combs S.E., Krieglstein K., Unsicker K. (2000) Reduction of endogenous TGF-beta increases proliferation of developing adrenal chromaffin cells in vivo.J. Neurosci. Res. 59379383.
  • 27
    Constam D.B., Schmid P., Aguzzi A., Schachner M., Fontana A. (1994) Transient production of TGF-β2 by postnatal cerebellar neurons and its effect on neuroblast proliferation.Eur. J. Neurosci. 6766778.
  • 28
    Da Cunha A. & Vitkovic L. (1992) Transforming growth factor beta 1 (TGF-β1) expression and regulation in rat cortical astrocytes. J. Neuroimmunol. 36157169.
  • 29
    Da Cunha A., Jefferson J.A., Jackson R.W., Vitkovic L. (1993) Glial cell-specific mechanisms of TGF-β1 induction by IL-1 in cerebral cortex. J. Neuroimmunol. 427185.
  • 30
    Daopin S., Piez K.A., Ogawa Y., Davies D.R. (1992) Crystal structure of transforming growth factor-beta 2: an unusual fold for the superfamily.Science 257369373.
  • 31
    Derynck R., Lindquist P.B., Lee A., Wen D., Tamm J., Graycar J.L., Rhee L., Mason A.J., Miller D.A., Coffey R.J., Moses H.L., Chen E.Y. (1988) A new type of transforming growth factor-beta, TGF-beta 3.EMBO J. 737373743.
  • 32
    Durbec P., Marcos-Gutierrez C.V., Kilkenny C., Grigoriou M., Wartiowaara K., Suvanto P., Smith D., Ponder B., Costantini F., Saarma M., Sariola H., Pachnis V. (1996) GDNF signalling through the Ret receptor tyrosine kinase.Nature 381789793.
  • 33
    Ebendal T., Bengtsson H., Söderström S. (1998) Bone morphogenetic proteins and their receptors: potential functions in the brain.J. Neurosci. Res. 51139146.
  • 34
    Eddleston M. & Mucke L. (1993) Molecular profile of reactive astrocytes—implications for their role in neurologic disease. Neuroscience 541536.
  • 35
    Eto Y., Tsuji T., Takezawa M., Takano S., Yokogawa X., Shibai H. (1987) Purification and characterization of erythroid differentiation factor (EDF) isolated from human leukemia cell line THP-1.Biochem. Biophys. Res. Commun. 14210951103.
  • 36
    Feng X.H., Zhang Y., Wu R.Y., Derynck R. (1998) The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGF-beta-induced transcriptional activation.Genes Dev. 1221532163.
  • 37
    Ferguson E.L. & Anderson K.V. (1992) Decapentaplegic acts as a morphogen to organize dorsal-ventral pattern in the Drosophila embryo.Cell 71451461.
  • 38
    Finch C.E., Laping N.J., Morgan T.E., Nicholson N.R., Pasinetti G.M. (1993) TGF-β1 is an organizer of responses to neurodegeneration. J. Cell. Biochem. 53314322.
  • 39
    Finotto S., Krieglstein K., Schober A., Deimling F., Lindner K., Bruhl B., Beier K., Metz J., Garcia-Arraras J.E., Roig-Lopez J.L., Monaghan P., Schmid W., Cole T.J., Kellendonk C., Tronche F., Schutz G., Unsicker K. (1999) Analysis of mice carrying targeted mutations of the glucocorticoid receptor gene argues against an essential role of glucocorticoid signalling for generating adrenal chromaffin cells system.Development 12629352944.
  • 40
    Flanders K.C., Lüdecke G., Engels S., Cissel D.S., Roberts A.B., Kondaiah P., Lafyatis R., Sporn M.B., Unsicker K. (1991) Localization and actions of transforming growth factor-βs in the embryonic nervous system. Development 113183191.
  • 41
    Flanders K.C., Lüdecke G., Renzig J., Hamm C., Cissel D.S., Unsicker K. (1993) Effect of TGF-βs and bFGF on astroglial cell growth and gene expression in vitro. Mol. Cell. Neurosci. 4406417.
  • 42
    Flanders K.C., Lippa C.F., Smith T.W., Pollen D.A., Sporn M.B. (1995) Altered expression of transforming growth factor-beta in Alzheimer's disease.Neurology 4515611569.
  • 43
    Flanders K.C., Fen R.F., Lippa C.F. (1998) Transforming growth factor-βs in neurodegenerative disease. Prog. Neurobiol. 547185.
  • 44
    Fok-Seang J., DiProspero N.A., Meiners S., Muir E., Fawcett J.W. (1998) Cytokine-induced changes in the ability of astrocytes to support migration of oligodendrocyte precursors and axon growth.Eur. J. Neurosci. 1024002415.
  • 45
    Franzen P., Heldin C.H., Miyazono K. (1995) The GS domain of the transforming growth factor-beta is important in signal transduction.Biochem. Biophys. Res. Commun. 207682689.
  • 46
    Gagelin C., Pierre M., Gavaret J.M., Toru-Delbauffe D. (1995) Rapid TGF beta 1 effects on actin cytoskeleton of astrocytes: comparison with other factors and implications for cell motility.Glia 13283293.
  • 47
    Galter D. & Unsicker K. (1999) Regulation of the transmitter phenotype of rostral and caudal groups of cultured serotonergic raphe neurons.Neuroscience 88549559.
  • 48
    Galter D., Bottner M., Unsicker K. (1999) Developmental regulation of the serotonergic transmitter phenotype in rostral and caudal raphe neurons by transforming growth factor-betas.J. Neurosci. Res. 56531538.
  • 49
    Gouin A., Bloch-Gallego E., Tanaka H., Rosenthal A., Henderson C.E. (1996) Transforming growth factor-beta 3, glial cell line derived neurotrophic factor, and fibroblast growth factor-2 act in different manners to promote motoneuron survival in vitro.J. Neurosci. Res. 43454464.
  • 50
    Grewal J.S., Mukhin Y.V., Garnovskaya M.N., Raymond J.R., Greene E.L. (1999) Serotonin 5-HT2A receptor induces TGF-betal expression in mesangial cells via ERK: proliferative and fibrotic signals.Am. J. Physiol. 276F922F930.
  • 51
    Griffith D.L., Keck P.C., Sampath T.K., Rueger D.C., Carlson W.D. (1996) Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor β superfamily.Proc. Natl. Acad. Sci. USA 93878883.
  • 52
    Hahn S.A., Schutte M., Hoque A.T., Moskaluk C.A., Da Costa L.T., Rozenblum E., Weinstein C.L., Fischer A., Yeo C.J., Hruban R.H., Kern S.E. (1996) DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1.Science 271350353.
  • 53
    Hatten M.E. (1999) Central nervous system neuronal migration.Annu. Rev. Neurosci. 22511539.
  • 54
    Heldin C.H., Miyazono K., Dijke P. (1997) TGF-beta signalling from cell membrane to nucleus through SMAD proteins.Nature 390465471.
  • 55
    Hill C.S. (1999) The Smads.Int. J. Biochem. Cell. Biol. 3112491254.
  • 56
    Hinck A.P., Archer S.J., Qian S.W.R, Sporn M.B., Weatherbee J.A., Tsang M.L., Lucas R., Zhang B.L., Wenker J., Torchia D.A. (1996) Transforming growth factor beta 1: three-dimensional structure in solution and comparison with the x-ray structure of transforming growth factor beta 2.Biochemistry 3585178534.
  • 57
    Hinks G.L. & Franklin R.J. (1999) Distinctive patterns of PDGF-A, FGF-2, IGF-I, and TGF-beta1 gene expression during remyelination of experimentally-induced spinal cord demyelination.Mol. Cell. Neurosci. 14153168.
  • 58
    Hogan B.L. (1996) Bone morphogenetic proteins: multifunctional regulators of vertebrate development.Genes Dev. 1015801594.
  • 59
    Hoodless P.A., Haerry T., Abdollah S., Stapleton M., O'Connor M.B., Attisano L., Wrana J.L. (1996) MADR1, a MAD-related protein that functions in BMP2 signaling pathways.Cell 85489500.
  • 60
    Howard M.J. & Gershon M.D. (1993) Role of growth factors in catecholaminergic expression by neural crest cells: in vitro effects of transforming growth factor beta 1.Dev. Dyn. 196110.
  • 61
    Hu S., Peterson P.K., Chao C.C. (1995) Cytokine modulation of murine microglial cell superoxide production.Glia 134550.
  • 62
    Hunter K.E., Sporn M.B., Davies A.M. (1993) Transforming growth factor-βs inhibit mitogen-stimulated proliferation of astrocytes. Glia 7203211.
  • 63
    Hurwitz A.A., Lyman W.D., Guida M.P., Calderon T.M., Berman J.W. (1992) Tumor necrosis factor alpha induces adhesion molecule expression on human fetal astrocytes.J. Exp. Med. 17616311636.
  • 64
    Imamura T., Takase M., Nishihara A., Oeda E., Hanai J., Kawabata M., Miyazono K. (1997) Smad6 inhibits signalling by the TGF-beta superfamily.Nature 389622626.
  • 65
    Ishihara A., Saito H., Abe K. (1994) Transforming growth factor-beta 1 and -beta 2 promote neurite sprouting and elongation of cultured rat hippocampal neurons.Brain Res. 6392125.
  • 66
    Itoh S., Landstrom M., Hermansson A., Itoh F., Heldin C.H., Heldin N.E., Dijke P. (1998) Transforming growth factor beta1 induces nuclear export of inhibitory Smad7.J. Biol. Chem. 2732919529201.
  • 67
    Jing S., Yu Y., Fang M., Hu Z., Holst P.L., Boone T., Delaney J., Schultz H., Zhou R., Fox G.M. (1997) GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family.J. Biol. Chem. 2723311133117.
  • 68
    Johns L.D., Babcock G., Green D., Freedman M., Sriram S., Ransohoff R.M. (1992) Transforming growth factor-beta 1 differentially regulates proliferation and MHC class-II antigen expression in forebrain and brainstem astrocyte primary cultures.Brain Res. 585229236.
  • 69
    Josso N. & Clemente N. (1997) Serine/threonine kinase receptors and ligands.Curr. Opin. Genet. Dev. 7371377.
  • 70
    Kiefer R., Streit W.J., Toykka K.V., Kreutzberg G.W., Hartung H.P. (1995) Transforming growth factor-beta 1: a lesion-associated cytokine of the nervous system.Int. J. Dev. Neurosci. 13331339.
  • 71
    Kingsley D.M. (1994) The TGF-β superfamily: new members, new receptors, and new genetic tests of function in different organisms.Genes. Dev. 8133146.
  • 72
    Kothapalli R., Buyuksal I., Wu S.Q., Chegini N., Tabibzadeh S. (1997) Detection of ebaf, a novel human gene of the transforming growth factor beta superfamily: association of gene expression with endometrial bleeding.J. Clin. Invest. 9923422350.
  • 73
    Kotzbauer P.T., Lampe P.A., Heuckeroth R.O., Golden J.P., Creedon D.J., Johnson E.M.J, Milbrandt J. (1996) Neurturin, a relative of glial-cell-line-derived neurotrophic factor.Nature 384467470.
  • 74
    Kretzschmar M. & Massague J. (1998) SMADs: mediators and regulators of TGF-beta signaling.Curr. Opin. Genet. Dev. 8103111.
  • 75
    Kretzschmar M., Liu F., Hata A., Doody J., Massague J. (1997) The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase.Genes Dev. 11984995.
  • 76
    Krieglstein K. & Unsicker K. (1994) Transforming growth factor-β promotes survival of midbrain dopaminergic neurons and protects them against N-methyl-4-phenylpyridinium ion toxicity. Neuroscience 6311891196.
  • 77
    Krieglstein K. & Unsicker K. (1995) Bovine chromaffin granules contain and release a transforming growth factor-β-like activity. J. Neurochem. 6514231426.
  • 78
    Krieglstein K. & Unsicker K. (1996) Distinct modulatory actions of TGF-β and LIF on neurotrophin-mediated survival of developing sensory neurons.Neurochem. Res. 21849856.
  • 79
    Krieglstein K., Rufer M., Suter-Crazzolara C., Unsicker K. (1995a) Neural functions of the transforming growth factors β. Int. J. Dev. Neurosci. 13301315.
  • 80
    Krieglstein K., Suter-Crazzolara C., Fischer W.H., Unsicker K. (1995b) TGF-β superfamily members promote survival of mid-brain dopaminergic neurons and protect them against MPP+ toxicity.EMBO J. 14736742.
  • 81
    Krieglstein K., Farkas L., Unsicker K. (1998a) TGF-beta regulates the survival of ciliary ganglionic neurons synergistically with ciliary neurotrophic factor and neurotrophins.J. Neurobiol. 37563572.
  • 82
    Krieglstein K., Henheik P., Farkas L., Jaszai J., Galter D., Krohn K., Unsicker K. (1998b) GDNF requires TGF-β for establishing its neurotrophic activity.J. Neurosci. 1898229834.
  • 83
    Labourdette G., Janet T., Laeng P., Perraud F., Lawrence D., Pettmann B. (1990) Transforming growth factor type beta 1 modulates the effects of basic fibroblast growth factor on growth and phenotypic expression of rat astroblasts in vitro.J. Cell. Physiol. 144473484.
  • 84
    Lagna G., Hata A., Hemmati-Brivanlou A., Massague J. (1996) Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.Nature 383832836.
  • 85
    Lawrence D.A. (1996) Transforming growth factor-beta: a general review.Eur. Cytokine Netw. 7363374.
  • 86
    Lee K.J. & Jessell T.M. (1999) The specification of dorsal cell fates in the vertebrate central nervous system.Annu. Rev. Neurosci. 22261294.
  • 87
    Lee Y.J., Han Y., Lu, H.T., Nguyen V., Qin H., Howe P.H., Hocevar B.A., Boss J.M., Ransohoff R.M., Benveniste E.N. (1997) TGF-beta suppresses IFN-gamma induction of class II MHC gene expression by inhibiting class II transactivator messenger RNA expression.J. Immunol. 15820652075.
  • 88
    Lin L.F., Doherty D.H., Lile J.D., Bektesh S., Collins F. (1993) GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons.Science 26011301132.
  • 89
    Lindholm D., Castren D., Kiefer R., Zafra F., Thoenen H. (1992) Transforming growth factor-β1 in the rat brain: increase after injury and inhibition of astrocyte proliferation. J. Cell Biol. 117395400.
  • 90
    Ling N., Ying S.Y., Ueno N., Esch F., Denoroy L., Guillemin R. (1985) Isolation and partial characterization of a Mr 32,000 protein with inhibin activity from porcine follicular fluid.Proc. Natl. Acad. Sci. USA 8272177221.
  • 91
    Liu F., Ventura F., Doody J., Massague J. (1995) Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs.Mol. Cell. Biol. 1534793486.
  • 92
    Liu F., Hata A., Baker J.C., Doody J., Carcamo J., Harland R.M., Massague J. (1996) A human Mad protein acting as a BMP-regulated transcriptional activator.Nature 381620623.
  • 93
    Lo R.S. & Massague J. (1999) Ubiquitin-dependent degradation of TGF-beta-activated Smad2.Nat. Cell Biol. 1472478.
  • 94
    Lodge P.A. & Sriram S. (1996) Regulation of microglial activation by TGF-beta, IL-10, and CSF-1.J. Leukoc. Biol. 60502508.
  • 95
    Lopez-Casillas F., Wrana J.L., Massague J. (1993) Betaglycan presents ligand to the TGF beta signaling receptor.Cell 7314351444.
  • 96
    Macias-Silva M., Abdollah S., Hoodless P.A., Pirone R., Attisano L., Wrana J.L. (1996) MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling.Cell 8712151224.
  • 97
    Madisen L., Webb N.R., Rose T.M., Marquardt H., Ikeda T., Twardzik D., Seyedin S., Purchio A.F. (1988) Transforming growth factor-beta 2: cDNA cloning and sequence analysis.DNA 718.
  • 98
    Martinou J., Le Van Thai A., Valette A., Weber M.J. (1990) Transforming growth factor β1 is a potent survival factor for rat embryo motoneurons in culture.Dev. Brain Res. 52175181.
  • 99
    Massague J. (1990) The transforming growth factor-beta family.Annu. Rev. Cell Biol. 6597641.
  •  
    Massague J. (1992) Receptors for the TGF-beta family.Cell 6910671070.
  • 101
    Massague J. (1998) TGF-beta signal transduction.Annu. Rev. Biochem. 67753791.
  • 102
    Massague J. & Weis-Garcia F. (1996) Serine/threonine kinase receptors: mediators of transforming growth factor beta family signals.Cancer Surv. 274164.
  •  
    Massague J., Attisano L., and Wrana J.L. (1994) The TGF-β family and its composite receptors.Trends Cell Biol. 4172178.
  • 104
    McDonald N.Q. & Hendrickson W.A. (1993) A structural super-family of growth factors containing a cystine knot motif.Cell 73421424.
  • 105
    McKinnon R.D., Piras G., Ida J.A.J, Dubois-Dalcq M. (1993) A role for TGF-beta in oligodendrocyte differentiation.J. Cell Biol. 12113971407.
  • 106
    McLennan I.S., Koishi K., Zhang M., Murakami N. (1998) The non-synaptic expression of transforming growth factor-beta 2 is neurally regulated and varies between skeletal muscle fibre types.Neuroscience 87845853.
  • 107
    McPherron A.C. & Lee S.J. (1993) GDF-3 and GDF-9: two new members of the transforming growth factor-β superfamily containing a novel pattern of cysteines.J. Biol. Chem. 26834443449.
  • 108
    Mehler M.F., Mabie P.C., Zhang D., Kessler J.A. (1997) Bone morphogenetic proteins in the nervous system.Trends Neurosci. 20309317.
  • 109
    Meno C., Saijoh Y., Fujii H., Ikeda M., Yokoyama T., Yokoyama M., Toyoda Y., Hamada H. (1996) Left-right asymmetric expression of the TGF beta-family member lefty in mouse embryos.Nature 381151155.
  • 110
    Milbrandt J., De Sauvage F.J., Fahrner T.J., Baloh R.H., Leitner M.L., Tansey M.G., Lampe P.A., Heuckeroth R.O., Kotzbauer P.T., Simburger K.S., Golden J.P., Davies J.A., Vejsada R., Kato A.C., Hynes M., Sherman D., Nishimura M., Wang L.C., Vandlen R., Moffat B., Klein R.D., Poulsen K., Gray C., Garces A., Johnson E.M.Jr. (1998) Persephin, a novel neurotrophic factor related to GDNF and neurturin.Neuron 20120.
  •  
    Morganti-Kossman M.C., Kossman T., Brandes M.E., Mergehagen S.E., and Wahl S.M. (1992) Autocrine and paracrine regulation of astrocyte function by transforming growth factor-β. J. Neuroimmunol. 39163174.
  • 112
    Moses H.L., Branum E.L., Proper J.A., Robinson R.A. (1981) Transforming growth factor production by chemically transformed cells.Cancer Res. 4128422848.
  • 113
    Nakao A., Afrakhte M., Moren A., Nakayama T., Christian J.L., Heuchel R., Itoh S., Kawabata M., Heldin N.E., Heldin C.H., Dijke P. (1997) Identification of Smad7, a TGF-beta-inducible antagonist of TGF-beta signalling.Nature 389631635.
  • 114
    Nathan C. & Sporn M. (1991) Cytokines in context.J. Cell Biol. 113981986.
  • 115
    Ohta M., Greenberger J.S., Anklesaria P., Bassols A., Massague J. (1987) Two forms of transforming growth factor-beta distinguished by multipotential haematopoietic progenitor cells.Nature 329539541.
  • 116
    Panek R.B., Lee Y.J., Benveniste E.N. (1995) TGF-β suppression of IFN-γ-induced class II MHC gene expression does not involve inhibition of phosphorylation of JAK1, JAK2, or signal transducers and activators of transcription, or modification of IFN-γ enhanced factor X expression.J. Immunol. 154610619.
  • 117
    Park S.K., Grzybicki D., Lin H.L., Murphy S. (1994) Modulation of inducible nitric oxide synthase expression in astroglial cells.Neuropharmacology 3314191423.
  • 118
    Pelton R.W., Dickinson M.E., Moses H.L., Hogan B.L.M. (1991a) In-situ hybridization analysis of TGF-β3 RNA expression during mouse development: comparative studies with TGF-β1 and -β2. Development 110609620.
  • 119
    Pelton R.W., Saxena B., Jones M., Moses H.L., Gold L.I. (1991b) Immunohistochemical localization of TGF-β1, TGF-β2 and TGFβ3 in mouse embryo: expression patterns suggest multiple roles during embryonic development. J. Cell Biol. 11510911105.
  • 120
    Peress N.S. & Perillo E. (1995) Differential expression of TGF-beta 1, 2 and 3 isotypes in Alzheimer's disease: a comparative immunohistochemical study with cerebral infarction, aged human and mouse control brains.J. Neuropathol. Exp. Neurol. 54802811.
  • 121
    Petraglia F., Vaughan J., Vale W. (1989) Inhibin and activin modulate the release of gonadotropin-releasing hormone, human chorionic gonadotropin, and progesterone from cultured human placenta cells.Proc. Natl. Acad. Sci. USA 8651145117
  •  
    Piek E., Heldin C.H., and ten Dijke P. (1999) Specificity, diversity, and regulation in TGF-beta superfamily signaling.FASEB J. 1321052124.
  • 123
    Poulsen K.T., Armanini M.P., Klein R.D., Hynes M.A., Phillips H.S., Rosenthal A. (1994) TGF beta 2 and TGF beta 3 are potent survival factors for midbrain dopaminergic neurons.Neuron 1312451252.
  • 124
    Pratt B.M. & McPherson J M. (1997) TGF-β in the central nervous system: potential roles in ischemic injury and neurodegenerative diseases.Cytokine Growth Factor Rev. 8267292.
  • 125
    Raftery L.A., Twombly V., Wharton K., Gelbart W.M. (1995) Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila. Genetics 139241254.
  • 126
    Raivich G., Jones J.J., Werner A., Bluthmann H., Doetschman T., Kreutzberg G.W. (1999) Molecular signals for glial activation: pro- and anti-inflammatory cytokines in the injured brain.Acta Neurochir. Suppl. 732130.
  • 127
    Reissmann E., Ernsberger U., Francis-West P.H., Rueger D., Brickell P.M., Rohrer H. (1996) Involvement of bone morphogenetic protein-4 and bone morphogenetic protein-7 in the differentiation of the adrenergic phenotype in developing sympathetic neurons.Development 12220792088.
  • 128
    Ren P., Lim C.S., Johnsen R., Albert P.S., Pilgrim D., Riddle D.L. (1996) Control of C. elegans larval development by neuronal expression of a TGF-beta homolog.Science 27413891391.
  • 129
    Roberts A.B. & Sporn M.B. (1990) The transforming growth factor-βs, in Handbook of Experimental Pharmacology, Vol. 95 (Sporn M. B. and Roberts A.B., eds), pp. 419472. Springer Verlag, Heidelberg.
  • 130
    Roberts A.B., Anzano M.A., Lamb L.C., Smith J.M., Sporn M.B. (1981) New class of transforming growth factors potentiated by epidermal growth factor: isolation from nonneoplastic tissues.Proc. Natl. Acad. Sci. USA 7853395343.
  • 131
    Roberts A.B., Anzano M.A., Meyers C.A., Wideman J., Blacher R., Pan Y.C., Stein S., Lehrman S.R., Smith J.M., Lamb L.C., Sporn M.B. (1983) Purification and properties of a type beta transforming growth factor from bovine kidney.Biochemistry 2256925698.
  • 132
    Roelink H., Porter J.A., Chiang C., Tanabe Y., Chang D.T., Beachy P.A., Jessell T.M. (1995) Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis.Cell 81445455.
  • 133
    Rosenblad C., Gronborg M., Hansen C., Blom N., Meyer M., Johansen J., Dago L., Kirik D., Patel U.A., Lundberg C., Trono D., Bjorklund A., Johansen T.E. (2000) In vivo protection of nigral dopamine neurons by lentiviral gene transfer of the novel GDNF-family member neublastin/artemin.Mol. Cell. Neurosci. 15199214.
  • 134
    Rosenzweig B.L., Imamura T., Okadome T., Cox G.N., Yamashita H., Dijke P., Heldin C.H., Miyazono K. (1995) Cloning and characterization of a human type II receptor for bone morphogenetic proteins.Proc. Natl. Acad. Sci. USA 9276327636.
  • 135
    Savage C., Das P., Finelli A.L., Townsend S.R., Sun C.Y., Baird S.E., Padgett R.W. (1996) Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components.Proc. Natl. Acad. Sci. USA 93790794.
  • 136
    Schluesener H.J. (1990) Transforming growth factors type beta 1 and beta 2 suppress rat astrocyte autoantigen presentation and antagonize hyperinduction of class II major histocompatibility complex antigen expression by interferon-gamma and tumor necrosis factor-alpha.J. Neuroimmunol. 274147.
  • 137
    Schlunegger M.P. & Grütter M.G. (1992) An unusual feature revealed by the crystal structure at 2.2 A resolution of human transforming growth factor-β2. Nature 358430434.
  • 138
    Schmid P., Cox D., Bilbe G., Maier R., McMaster G.K. (1991) Differential expression of TGF beta 1, beta 2 and beta 3 genes during mouse embryogenesis.Development 111117130.
  • 139
    Schnädelbach O., Mandl C., Faissner A. (1998) Expression of DSD-1-PG in primary neural and glial-derived cell line cultures, upregulation by TGF-beta, and implications for cell-substrate interactions of the glial cell line Oli-neu.Glia 2399119.
  • 140
    Schober A., Hertel R., Arumae U., Farkas L., Jaszai J., Krieglstein K., Saarma M., Unsicker K. (1999) Glial cell line-derived neurotrophic factor rescues target-deprived sympathetic spinal cord neurons but requires transforming growth factor-beta as cofactor in vivo.J. Neurosci. 1920082015.
  • 141
    Sekelsky J.J., Newfeld S.J., Raftery L.A., Chartoff E.H., Gelbart W.M. (1995) Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster. Genetics 13913471358.
  • 142
    Shah N.M., Groves A.K., Anderson D.J. (1996) Alternative neural crest cell fates are instructively promoted by TGFbeta superfamily members.Cell 85331343.
  • 143
    Shrikant P., Chung I.Y., Ballestas M.E., Benveniste E.N. (1994) Regulation of intercellular adhesion molecule-1 gene expression by tumor necrosis factor-alpha, interleukin-1 beta, and interferon-gamma in astrocytes.J. Neuroimmunol. 51209220.
  • 144
    Shrikant P., Lee S.J., Kalvakolanu I., Ransohoff R.M., Benveniste E.N. (1996) Stimulus-specific inhibition of intracellular adhesion molecule-1 gene expression by TGF-beta.J. Immunol. 157892900.
  • 145
    Smith J.C., Price B.M., Van Nimmen K., Huylebroeck D. (1990) Identification of a potent Xenopus mesodem-inducing factor as a homologue of activin A.Nature 345729731.
  • 146
    Sun P.D. & Davies D.R. (1995) The cystine-knot growth-factor superfamily.Annu. Rev. Biophys. Biomol. Struct. 24269291.
  • 147
    Suzumura A., Sawada M., Yamamoto H., Marunouchi T. (1993) Transforming growth factor-beta suppresses activation and proliferation of microglia in vitro.J. Immunol. 15121502158.
  • 148
    Thompson J., Doxakis E., Pinon L.G., Strachan P., Buj-Bello A., Wyatt S., Buchman V.L., Davies A.M. (1998) GFRalpha-4, a new GDNF family receptor.Mol. Cell. Neurosci. 11117126.
  • 149
    Thomsen G.H. & Melton D.A. (1993) Processed Vgl protein is an axial mesoderm inducer in Xenopus. Cell 744433441.
  • 150
    Toepfer M., Fischer P., Abicht A., Lochmuller H., Pongratz D., Muller-Felber W. (1999) Localization of transforming growth factor beta in association with neuromuscular junctions in adult human muscle.Cell. Mol. Neurobiol. 19297300.
  • 151
    Toru-Delbauffe D., Baghdassarian-Chalaye D., Gavaret J.M., Courtin F., Pomerance M., Pierre M. (1990) Effects of transforming growth factor beta 1 on astroglial cells in culture.J. Neurochem. 5410561061.
  • 152
    Treanor J.J., Goodman L., De Sauvage F., Stone D.M., Poulsen K.T., Beck C.D., Gray C., Armanini M.P., Pollock R.A., Hefti F., Phillips H.S., Goddard A., Moore M.W., Buj-Bello A., Davies A.M., Asai N., Takahashi M., Vandlen R., Henderson C.E., Rosenthal A. (1996) Characterization of a multicomponent receptor for GDNF.Nature 3828083.
  • 153
    Trupp M., Arenas E., Fainzilber M., Nilsson A.S., Sieber B.A., Grigoriou M., Kilkenny C., Salazar-Grueso E., Pachnis V., Arumae U., Sariola H., Saarma M., Ibanez C.F. (1996) Functional receptor for GDNF encoded by the c-ret proto-oncogene.Nature 381785789.
  • 154
    Tsukazaki T., Chiang T.A., Davison A.F., Attisano L., Wrana J.L. (1998) SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor.Cell 95779791.
  • 155
    Unsicker K. (1993) The chromaffin cell: paradigm in cell development and growth factor biology.J. Anat. 183207221.
  • 156
    Unsicker K. & Krieglstein K. (1996) Growth factors in chromaffin cells.Prog. Neurobiol. 48307324.
  • 157
    Unsicker K., Flanders K.C., Cissel D.S., Lafyatis R., Sporn M.B. (1991) Transforming growth factor beta isoforms in the adult rat central and peripheral nervous system.Neuroscience 44613625.
  • 158
    Unsicker K., Meier C., Krieglstein K., Sartor B.M., Flanders K.C. (1996) Expression, localization, and function of transforming growth factor-βs in embryonic chick spinal cord, hindbrain, and dorsal root ganglia. J. Neurobiol. 29262276.
  • 159
    Unsicker K., Suter-Crazzolara C., Krieglstein K. (1999) Neurotrophic roles of GDNF and related factors, inHandbook of Experimental Pharmacology, Vol. 134: Neurotrophic Factors (Hefti F., ed), pp. 189224. Springer Verlag, Heidelberg.
  • 160
    Vale W., Rivier J., Vaughan J., McClintock R., Corrigan A., Woo W., Karr D., Spiess J. (1986) Purification and characterization of an FSH releasing protein from porcine ovarian follicular fluid.Nature 321776779.
  • 161
    Vodovotz Y., Geiser A.G., Chesler L., Letterio J.J., Campbell A., Lucia M.S., Sporn M.B., Roberts A.B. (1996) Spontaneously increased production of nitric oxide and aberrant expression of the inducible nitric oxide synthase in vivo in the transforming growth factor beta 1 null mouse.J. Exp. Med. 18323372342.
  • 162
    Wahl S.M. (1992) Transforming growth factor beta (TGF-β) in inflammation: a cause and a cure. J. Clin. Immunol. 126674.
  • 163
    Weeks D.L. & Melton D.A. (1987) A maternal mRNA localized to the vegetal hemisphere in Xenopus eggs codes for a growth factor related to TGF-beta.Cell 51861867.
  • 164
    Wieser R., Wrana J.L., Massague J. (1995) GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex.EMBO J. 1421992208.
  • 165
    Willis S.A., Zimmerman C.M., Li L.I., Mathews L.S. (1996) Formation and activation by phosphorylation of activin receptor complexes.Mol. Endocrinol. 10367379.
  • 166
    Wolf N., Krohn K., Bieger S., Frodin M., Gammeltoft S., Krieglstein K., Unsicker K. (1999) Transforming growth factor-beta, but not ciliary neurotrophic factor, inhibits DNA synthesis of adrenal medullary cells in vitro.Neuroscience 90629641.
  • 167
    Wotton D., Lo R.S., Lee S., Massague J. (1999) A Smad transcriptional corepressor.Cell 972939.
  • 168
    Wozney J.M., Rosen V., Celeste A.J., Mitsock L.M., Whitters M.J., Kriz R.W., Hewick R.M., Wang E.A. (1988) Novel regulators of bone formation: molecular clones and activities.Science 24215281534.
  • 169
    Wrana J.L., Attisano L., Carcamo J., Zentella A., Doody J., Laiho M., Wang X.F., Massague J. (1992) TGF beta signals through a heteromeric protein kinase receptor complex.Cell 7110031014.
  •  
    Wrana J.L., Attisano L., Wieser R., Ventura F., and Massague J. (1994) Mechanism of activation of the TGF-beta receptor.Nature 370341347.
  • 171
    Xiao B.G., Zhang G.X., Ma C.G., Link H. (1996) Transforming growth factor-beta 1 (TGF-beta1)-mediated inhibition of glial cell proliferation and down-regulation of intercellular adhesion molecule-1 (ICAM-1) are interrupted by interferon-gamma (IFN-gamma).Clin. Exp. Immunol. 103475481.
  • 172
    Xiao B.G., Bai X.F., Zhang G.X., Link H. (1997) Transforming growth factor-betal induces apoptosis of rat microglia without relation to bcl-2 oncoprotein expression.Neurosci. Lett. 2267174.
  • 173
    Yamashita H., Dijke P., Franzen P., Miyazono K., Heldin C.H. (1994) Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-beta.J. Biol. Chem. 2692017220178.
  • 174
    Zhang F., Endo S., Cleary L.J., Eskin A., Byrne J.H. (1997) Role of transforming growth factor-beta in long-term synaptic facilitation in Aplysia. Science 27513181320.
  • 175
    Zhang Y., Feng X., We R., Derynck R. (1996) Receptor-associated Mad homologues synergize as effectors of the TGF-beta response.Nature 383168172.
  • 176
    Zhou X., Sasaki H., Lowe L., Hogan B.L., Kuehn M.R. (1993) Nodal is a novel TGF-beta-like gene expressed in the mouse node during gastrulation.Nature 361543547.