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Acknowledgements

This research is supported by the Alzheimer's Association and NationalInstitutes of Health grants MH38752, NS37768, and NS10795.

  • 1
    Alessi D.R., James S.R., Downes C.P., Holmes A.B., Gaffney P.R., Reese C.B., Cohen P. (1997) Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα. Curr. Biol. 7261269.
  • 2
    Bijur G.N., De Sarno P., Jope R.S. (2000) Glycogen synthase kinase-3β facilitates staurosporine and heat shock-induced apoptosis.J. Biol. Chem. 27575837590.
  • 3
    Bradford M.M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein—dye binding. Anal. Biochem. 72248254.
  • 4
    Brown I.R. & Rush S.J. (1999) Cellular localization of the heat shock transcription factors HSF1 and HSF2 in the rat brain during postnatal development and following hyperthermia.Brain Res. 821333340.
  • 5
    Bruening W., Roy J., Giasson B., Figlewicz D.A., Mushynski W.E., Durham H.D. (1999) Up-regulation of protein chaperones preserves viability of cells expressing toxic Cu/Zn-superoxide dismutase mutants associated with amyotrophic lateral sclerosis.J. Neurochem. 72693699.
  • 6
    Bush K.T., Goldberg A.L., Nigam S.K. (1997) Proteasome inhibition leads to a heat-shock response, induction of endoplasmic reticulum chaperones, and thermotolerance.J. Biol. Chem. 27290869092.
  • 7
    Caruccio L., Bae S., Liu A.Y., Chen K.Y. (1997) The heat-shock transcription factor HSF1 is rapidly activated by either hyper- or hypo-osmotic stress in mammalian cells.Biochem. J. 327341347.
  • 8
    Chai Y., Koppenhafer S.L., Bonini N.M., Paulson H.L. (1999) Analysis of the role of heat shock protein (Hsp) molecular chaperones in polyglutamine disease.J. Neurosci. 191033810347.
  • 9
    Chu B., Soncin F., Price B.D., Stevenson M.A., Calderwood S.K. (1996) Sequential phosphorylation by mitogen-activated protein kinase and glycogen synthase kinase 3 represses transcriptional activation by heat shock factor-1.J. Biol. Chem. 2713084730857.
  • 10
    Coffer P.J., Jin J., Woodgett J.R. (1998) Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.Biochem. J. 335113.
  • 11
    Cook D., Fry M.J., Hughes K., Sumathipala R., Woodgett J.R., Dale T.C. (1996) Wingless inactivates glycogen synthase kinase-3 via an intracellular signalling pathway which involves a protein kinase C.EMBO J. 1545264536.
  • 12
    Cross D.A., Alessi D.R., Cohen P., Andjelkovich M., Hemmings B.A. (1995) Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B.Nature 378785789.
  • 13
    Cummings C.J., Mancini M.A., Antalffy B., DeFranco D.B., Orr H.T., Zoghbi H.Y. (1998) Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.Nat. Genet. 19148154.
  • 14
    Edwards M.J. (1998) Apoptosis, the heat shock response, hyperthermia, birth defects, disease and cancer. Where are the common links?Cell Stress Chaperones 3213220.
  • 15
    Gomer C.J., Ryter S.W., Ferrario A., Rucker N., Wong S., Fisher A.M. (1996) Photodynamic therapy-mediated oxidative stress can induce expression of heat shock proteins.Cancer Res. 5623552360.
  • 16
    Green M., Schuetz T.J., Sullivan E.K., Kingston R.E. (1995) A heat shock-responsive domain of human HSF1 that regulates transcription activation domain function.Mol. Cell. Biol. 1533543362.
  • 17
    He B., Meng Y.H., Mivechi N.F. (1998) Glycogen synthase kinase 3β and extracellular signal-regulated kinase inactivate heat shock transcription factor 1 by facilitating the disappearance of transcriptionally active granules after heat shock.Mol. Cell. Biol. 1866246633.
  • 18
    Jäättelä M. (1999) Heat shock proteins as cellular lifeguards.Ann. Med. 31261271.
  • 19
    Jacquier-Sarlin M.R. & Polla B.S. (1996) Dual regulation of heat-shock transcription factor (HSF) activation and DNA-binding activity by H2O2: role of thioredoxin. Biochem. J. 318187193.
  • 20
    Kawazoe Y., Nakai A., Tanabe M., Nagata K. (1998) Proteasome inhibition leads to the activation of all members of the heat-shock-factor family.Eur. J. Biochem. 255356362.
  • 21
    Klein P.S. & Melton D.A. (1996) A molecular mechanism for the effect of lithium on development.Proc. Natl. Acad. Sci. USA 9384558459.
  • 22
    Kline M.P. & Morimoto R.I. (1997) Repression of the heat shock factor 1 transcriptional activation domain is modulated by constitutive phosphorylation.Mol. Cell. Biol. 1721072115.
  • 23
    Knauf U., Newton E.M., Kyriakis J., Kingston R.E. (1996) Repression of human heat shock factor 1 activity at control temperature by phosphorylation.Genes Dev. 1027822793.
  • 24
    Konishi H., Matsuzaki H., Tanaka M., Ono Y., Tokunaga C., Kuroda S., Kikkawa U. (1996) Activation of RAC-protein kinase by heat shock and hyperosmolarity stress through a pathway independent of phosphatidylinositol 3-kinase.Proc. Natl. Acad. Sci. USA 9376397643.
  • 25
    Lin R.Z., Hu Z.W., Chin J.H., Hoffman B.B. (1997) Heat shock activates c-Src tyrosine kinases and phosphatidylinositol 3-kinase in NIH3T3 fibroblasts.J. Biol. Chem. 2723119631202.
  • 26
    Liu H., Lightfoot R., Stevens J.L. (1996) Activation of heat shock factor by alkylating agents is triggered by glutathione depletion and oxidation of protein thiols.J. Biol. Chem. 27148054812.
  • 27
    Marcuccilli C.J., Mathur S.K., Morimoto R.I., Miller R.J. (1996) Regulatory differences in the stress response of hippocampal neurons and glial cells after heat shock.J. Neurosci. 15478485.
  • 28
    Marini A.M., Kozuka M., Lipsky R.H., Nowak T.S.Jr. (1990) 70-kilodalton heat shock protein induction in cerebellar astrocytes and cerebellar granule cells in vitro: comparison with immunocytochemical localization after hyperthermia in vivo.J. Neurochem. 5415091516.
  • 29
    Mathur S.K., Sistonen L., Brown I.R., Murphy S.P., Sarge K.D., Morimoto R.I. (1994) Deficient induction of human hsp70 heat shock gene transcription in Y79 retinoblastoma cells despite activation of heat shock factor 1.Proc. Natl. Acad. Sci. USA 9186958699.
  • 30
    Morano K.A. & Thiele D.J. (1999) Heat shock factor function and regulation in response to cellular stress, growth, and differentiation signals.Gene Expr. 7271282.
  • 31
    Morimoto R.I. (1998) Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators.Genes Dev. 1237883796.
  • 32
    Nishimura R.N., Dwyer B.E., Vinters H.V., De Vellis J., Cole R. (1991) Heat shock in cultured neurons and astrocytes: correlation of ultrastructure and heat shock protein synthesis.Neuropathol. Appl. Neurobiol. 17139147.
  • 33
    Pap M. & Cooper G.M. (1998) Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-kinase/Akt cell survival pathway.J. Biol. Chem. 2731992919932.
  • 34
    Rossi A., Elia G., Santoro M.G. (1998) Activation of the heat shock factor 1 by serine protease inhibitors. An effect associated with nuclear factor-κB inhibition. J. Biol. Chem. 2731644616452.
  • 35
    Sarge K.D., Murphy S.P., Morimoto R.I. (1993) Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress.Mol. Cell. Biol. 1313921407.
  • 36
    Shaw M., Cohen P., Alessi D.R. (1998) The activation of protein kinase B by H2O2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2.Biochem. J. 336241246.
  • 37
    Shi Y., Mosser D.D., Morimoto R.I. (1998) Molecular chaperones as HSF1-specific transcriptional repressors.Genes Dev. 12654666.
  • 38
    Xia W. & Voellmy R. (1997) Hyperphosphorylation of heat shock transcription factor 1 is correlated with transcriptional competence and slow dissociation of active factor trimers.J. Biol. Chem. 27240944102.
  • 39
    Zou J., Guo Y., Guettouche T., Smith D.F., Voellmy R. (1998) Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1.Cell 94471480.
  • 40
    Zuo J., Rungger D., Voellmy R. (1995) Multiple layers of regulation of human heat shock transcription factor 1.Mol. Cell. Biol. 1543194330.