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Acknowledgements

We thank Julie Collins and Matt Oswald for help with the HO-1immunohistochemistry studies, Don Warn and Patrick Moonasar for assistancewith the preparation of the figures, and Dr. Dennis Wallace for help withstatistical analyses. This work was supported by NIH (NS 33596) and an NICHDMental Retardation Research Center grant (HD 02528).

  • 1
    Balla G., Jacob H.S., Balla J., Rosenberg M., Nath K., Apple F., Eaton J.W., Vercellotti G.M. (1992) Ferritin: a cytoprotective antioxidant stratagem of endothelium.J. Biol. Chem. 2671814818153.
  • 2
    Bergh A.F. & Strobel H.W. (1992) Reconstitution of the brain mixed function oxidase system: purification of NADPH-cytochrome P450 reductase and partial purification of cytochrome P450 from whole rat brain.J. Neurochem. 59575581.
  • 3
    Bourrie B., Bribes E., Esclangon M., Garcia L., Marchand J., Thomas C., Maffrand J.P., Casellas P. (1999) The neuroprotective agent SR 57746A abrogates experimental autoimmune encephalomyelitis and impairs associated blood-brain barrier disruption: implications for multiple sclerosis treatment.Proc. Natl. Acad. Sci. USA 961285512859.
  • 4
    Brown R.C., Cascio C., Papadopoulos V. (2000) Pathways of neurosteroid biosynthesis in cell lines from human brain: regulation of dehydroepiandrosterone formation by oxidative stress and beta-amyloid peptide.J. Neurochem. 74847859.
  • 5
    Cross A.H., Keeling R.M., Goorha S., San M., Rodi C., Wyatt P.S., Manning P.T., Misko T.P. (1996) Inducible nitric oxide synthase gene expression and enzyme activity correlate with disease activity in murine experimental autoimmune encephalomyelitis.J. Neuroimmunol. 71145153.
  • 6
    Cross A.H., Manning P.T., Stern M.K., Misko T.P. (1997) Evidence for the production of peroxynitrite in inflammatory CNS demyelination.J. Neuroimmunol. 80121130.
  • 7
    Dalton T., Pazdernik T.L., Wagner J., Samson F., Andrews G.K. (1995) Temporal spatial patterns of expression of metallothionein-I and -III and other stress related genes in rat brain after kainic acid-induced seizures.Neurochem. Int. 275971.
  • 8
    Deininger M.H. & Schluesener H.J. (1999) Cyclooxygenases-1 and -2 are differentially located to microglia and endothelium in rat EAE and glioma.J. Neuroimmunol. 95202208.
  • 9
    Doré S., Takahashi M., Ferris C.D., Hester L.D., Guastella D., Snyder S.H. (1999) Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury.Proc. Natl. Acad. Sci. USA 9624452450.
  • 10
    Dwyer B.E., Lu S.Y., Laitinen J.T., Nishimura R.N. (1998) Protective properties of tin- and manganese-centered porphyrins against hydrogen peroxide-mediated injury in rat astroglial cells.J. Neurochem. 7124972504.
  • 11
    Eisenstein R.S., Garcia-Mayol D., Pettingell W., Munro H.N. (1991) Regulation of ferritin and heme oxygenase synthesis in rat fibroblasts by different forms of iron.Proc. Natl. Acad. Sci. USA 88688692.
  • 12
    Elbirt K.K. & Bonkovsky H.L. (1999) Heme oxygenase: recent advances in understanding its regulation and role.Proc. Assoc. Am. Phys. 111438447.
  • 13
    Ewing J.F. & Maines M.D. (1991) Rapid induction of heme oxygenase 1 mRNA and protein by hyperthermia in rat brain: heme oxygenase 2 is not a heat shock protein.Proc. Natl. Acad. Sci. USA 8853645368.
  • 14
    Ewing J.F. & Maines M.D. (1993) Glutathione depletion induces heme oxygenase-1 (HSP32) mRNA and protein in rat brain.J. Neurochem. 6015121519.
  • 15
    Ewing J.F., Haber S.N., Maines M.D. (1992) Normal and heat-induced patterns of expression of heme oxygenase-1 (HSP32) in rat brain: hyperthermia causes rapid induction of mRNA and protein.J. Neurochem. 5811401149.
  • 16
    Forge J.K., Pedchenko T.V., LeVine S.M. (1998) Iron deposits in the central nervous system of SJL mice with experimental allergic encephalomyelitis.Life Sci. 6322712284.
  • 17
    Fukuda Y. & Sassa S. (1993) Effect of interleukin-11 on the levels of mRNAs mRNAs encoding heme oxygenase and haptoglobin in human HepG2 hepatoma cells.Biochem. Biophys. Res. Commun. 193297302.
  • 18
    Hansen L.A. & Pender M.P. (1989) Hypothermia due to an ascending impairment of shivering in hyperacute experimental allergic encephalomyelitis in the Lewis rat.J. Neurol. Sci. 94231240.
  • 19
    Hewett S.J., Misko T.P., Keeling R.M., Behrens M.M., Choi D.W., Cross A.H. (1996) Murine encephalitogenic lymphoid cells induce nitric oxide synthase in primary astrocytes.J. Neuroimmunol. 64201208.
  • 20
    Hodges V.M., Molloy G.Y., Wickramasinghe S.N. (2000) Demonstration of mRNA for five species of cytochrome P450 in human bone marrow, bone marrow-derived macrophages and human haemopoietic cell lines.Br. J. Haematol. 108151156.
  • 21
    Jung S., Donhauser T., Toyka K.V., Hartung H.P. (1997) Propentofylline and iloprost suppress the production of TNF-α by macrophages but fail to ameliorate experimental autoimmune encephalomyelitis in Lewis rats.J. Autoimmun. 10519529.
  • 22
    Kappus H. (1993) Metabolic reactions: role of cytochrome P-450 in the formation of reactive oxygen species, inCytochrome P450 (Schenkman J. B. and Grein H., eds), pp. 145154. Springer-Verlag, Berlin.
  • 23
    Koizumi T., Odani N., Okuyama T., Ichikawa A., Negishi M. (1995) Identification of a cis-regulatory element for ▵12-prostaglandin J2-induced expression of the rat heme oxygenase gene. J. Biol. Chem. 2702177921784.
  • 24
    Kondo A., Nakano T., Suzuki K. (1987) Blood-brain barrier permeability to horseradish peroxidase in twitcher and cuprizone intoxicated mice.Brain Res. 425186190.
  • 25
    Kostic T., Andric S., Maric D., Kovacevic R. (1998) The effect of acute stress and opioid antagonist on the activity of NADPH-P450 reductase in rat Leydig cells.J. Steroid Biochem. Mol. Biol. 665154.
  • 26
    Laemmli U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4.Nature 227680685.
  • 27
    Lavrovsky Y., Schwartzman M.L., Levere R.D., Kappas A., Abraham N.G. (1994) Identification of binding sites for transcription factors NF-χB and AP-2 in the promoter region of the human heme oxygenase 1 gene. Proc. Natl. Acad. Sci. USA 9159875991.
  • 28
    Llesuy S.F. & Tomaro M.L. (1994) Heme oxygenase and oxidative stress. Evidence of involvement of bilirubin as physiological protector against oxidative damage.Biochim. Biophys. Acta 1223914.
  • 29
    Maines M.D. (1988) Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications.FASEB J. 225572568.
  • 30
    Maines M.D. (1997) The heme oxygenase system: a regulator of second messenger gases.Annu. Rev. Pharmacol. Toxicol. 37517554.
  • 31
    Maines M.D. & Kappas A. (1977) Metals as regulators of heme metabolism.Science 19812151221.
  • 32
    Maines M.D., Trakshel G.M., Kutty R.K. (1986) Characterization of two constitutive forms of rat liver microsomal heme oxygenase. Only one molecular species of the enzyme is inducible.J. Biol. Chem. 261411419.
  • 33
    Massa S.M., Swanson R.A., Sharp F.R. (1996) The stress gene response in brain.Cerebrovasc. Brain Metab. Rev. 895158.
  • 34
    Misko T.P., Trotter J.L., Cross A.H. (1995) Mediation of inflammation by encephalitogenic cells: interferon-γ induction of nitric oxide synthase and cyclooxygenase 2.J. Neuroimmunol. 61195204.
  • 35
    Nicholson T.E. & Renton K.W. (1999) Modulation of cytochrome P450 by inflammation in astrocytes.Brain Res. 8271218.
  • 36
    Panahian N., Yoshiura M., Maines M.D. (1999) Overexpression of heme oxygenase-1 is neuroprotective in a model of permanent middle cerebral artery occlusion in transgenic mice.J. Neurochem. 7211871203.
  • 37
    Pedchenko T.V. & LeVine S.M. (1998) Desferrioxamine suppresses MBP induced experimental allergic encephalomyelitis in SJL mice.J. Neuroimmunol. 84188197.
  • 38
    Pedchenko T.V. & LeVine S.M. (1999) IL-6 deficiency causes enhanced pathology in twitcher (globoid cell leukodystrophy) mice.Exp. Neurol. 158459468.
  • 39
    Poss K.D. & Tonegawa S. (1997a) Heme oxygenase I is required for mammalian iron reutilization.Proc. Natl. Acad. Sci. USA 941091910924.
  • 40
    Poss K.D. & Tonegawa S. (1997b) Reduced stress defense in heme oxygenase 1-deficient cells.Proc. Natl. Acad. Sci. USA 941092510930.
  • 41
    Prineas J.W. & McDonald W.I. (1997) Demyelinating diseases, inGreenfield's Neuropathology, Vol. 1 (Graham D. I. and Lantos P. L., eds), pp. 813896. Oxford University Press, New York.
  • 42
    Raine C.S. (1984) Biology of disease. The analysis of autoimmune demyelination: its impact on multiple sclerosis.Lab. Invest. 50608635.
  • 43
    Raine C.S., Barnett L.B., Brown A., Behar T., McFarlin D.E. (1980) Neuropathology of experimental allergic encephalomyelitis in inbred strains of mice.Lab. Invest. 43150157.
  • 44
    Raine C.S., Cannella B., Hauser S.L., Genain C.P. (1999) Demyelination in primate autoimmune encephalomyelitis and acute multiple sclerosis lesions: a case for antigen-specific antibody mediation.Ann. Neurol. 46144160.
  • 45
    Ravindranath V. (1998) Metabolism of xenobiotics in the central nervous system: implications and challenges.Biochem. Pharmacol. 56547551.
  • 46
    Reder A.T., Thapar M., Sapugay A.M., Jensen M.A. (1994) Prostaglandins and inhibitors of arachidonate metabolism suppress experimental allergic encephalomyelitis.J. Neuroimmunol. 54117127.
  • 47
    Rossi A. & Santoro M.G. (1995) Induction by prostaglandin A1 of haem oxygenase in myoblastic cells: an effect independent of expression of the 70 kDa heat shock protein.Biochem. J. 308455463.
  • 48
    Sahrbacher U.C., Lechner F., Eugster H.P., Frei K., Lassmann H., Fontana A. (1998) Mice with an inactivation of the inducible nitric oxide synthase gene are susceptible to experimental autoimmune encephalomyelitis.Eur. J. Immunol. 2813321338.
  • 49
    Sakai N., Inui K., Tatsumi N., Fukushima H., Nishigaki T., Taniike M., Nishimoto J., Tsukamoto H., Yanagihara I., Ozono K., Okada S. (1996) Molecular cloning and expression of cDNA for murine galactocerebrosidase and mutation analysis of the twitcher mouse, a model of Krabbe's disease.J. Neurochem. 6611181124.
  • 50
    Schipper H.M., Bernier L., Mehindate K., Frankel D. (1999) Mitochondrial iron sequestration in dopamine-challenged astroglia: role of heme oxygenase-1 and the permeability transition pore.J. Neurochem. 7218021811.
  •  
    Scholz R.W., Reddy P.V., Liken A.D., and Reddy C.C. (1996) Inhibition of rat liver microsomal NADPh cytochrome P450 reductase by glutathione and glutathione disulfide.Biochem. Biophys. Res. Commun. 226475480.
  • 52
    Sewerynek E., Abe M., Reiter R.J., Barlow-Walden L.R., Chen L., McCabe T.J., Roman L.J., Diaz-Lopez B. (1995) Melatonin administration prevents lipopolysaccharide-induced oxidative damage in phenobarbital-treated animals.J. Cell. Biochem. 58436444.
  • 53
    Singh S.V., Iqbal J., Krishnan A. (1990) Cytochrome P450 reductase, antioxidant enzymes and cellular resistance to doxorubicin.Biochem. Pharmacol. 40385387.
  • 54
    Snawder J.E., Tirmenstein M.A., Mathias P.I., Toraason M. (1999) Induction of stress proteins in rat cardiac myocytes by antimony.Toxicol. Appl. Pharmacol. 1599197.
  • 55
    Stocker R., Yamamoto Y., McDonagh A.F., Glazer A.N., Ames B.N. (1987) Bilirubin is an antioxidant of possible physiological importance.Science 23510431046.
  • 56
    Strandell E., Buschard K., Saldeen J., Welsh N. (1995) Interleukin-1 beta induces the expression of hsp70, heme oxygenase and Mn-SOD in FACS-purified rat islet beta-cells, but not in alpha-cells.Immunol. Lett. 48145148.
  • 57
    Tenhunen R., Marver H.S., Schmid R. (1968) The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase.Proc. Natl. Acad. Sci. USA 61748755.
  • 58
    Terry C.M., Clikeman J.A., Hoidal J.R., Callahan K.S. (1999) TNF-α and IL-1α induce heme oxygenase-1 via protein kinase C, Ca2+, and phospholipase A2 in endothelial cells.Am. J. Physiol. 276H1493H1501.
  • 59
    Tran E.H., Hardin-Pouzet H., Verge G., Owens T. (1997) Astrocytes and microglia express inducible nitric oxide synthase in mice with experimental allergic encephalomyelitis.J. Neuroimmunol. 74121129.
  • 60
    Vile G.F. & Tyrrell R.M. (1993) Oxidative stress resulting from ultraviolet A irradiation of human skin fibroblasts leads to a heme oxygenase-dependent increase in ferritin.J. Biol. Chem. 2681467814681.
  • 61
    Vile G.F., Basu-Modak S., Waltner C., Tyrrell R.M. (1994) Heme oxygenase-1 mediates an adaptive response to oxidative stress in human skin fibroblasts.Proc. Natl. Acad. Sci. USA 9126072610.
  • 62
    Yasukochi Y. & Masters B.S. (1976) Some properties of a detergent-solubilized NADPH-cytochrome c (cytochrome P-450) reductase purified by biospecific affinity chromatography.J. Biol. Chem. 25153375344.
  • 63
    Zakhary R., Poss K.D., Jaffrey S.R., Ferris C.D., Tonegawa S., Snyder S.H. (1997) Targeted gene deletion of heme oxygenase 2 reveals neural role for carbon monoxide.Proc. Natl. Acad. Sci. USA 941484814853.
  • 64
    Zwain I.H. & Yen S.S. (1999) Neurosteroidogenesis in astrocytes, oligodendrocytes, and neurons of cerebral cortex of rat brain.Endocrinology 14038433852.