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  • Balthazart J. & Ball G. F. (1998) New Insights into the regulation and function of brain estrogen synthase (aromatase). Trends Neurosci. 21, 243249.
  • Behl C., Skutella T., Lezoualc'H F., Post A., Widmann M., Newton C., Holsboer F. (1997) Neuroprotection against oxidative stress by estrogens: structure-activity relationship. Mol. Pharmacol. 51, 535541.
  • Birge S. (1996) Is there a role for estrogen replacement therapy in the prevention and treatment of dementia? JAGS 44, 865870.
  • Brinton R. D., Tran J., Proffitt P., Montoya M. (1997) 17 β-estradiol enhances the outgrowth and survival of neocortical neurons in culture. Neurochem. Res. 22, 13391351.
  • Brogden R. N. & Chrisp P. (1991) Flutamide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in advanced prostatic cancer. Drugs Aging 1, 104115.
  • Clancy A. N., Bonsall R. W., Micheal R. P. (1992) Immunocytochemical labeling of androgen receptors in the brain of rat and monkey. Life Sci. 50, 409417.
  • Davis S. (1999) Androgen replacement in women: a commentary. J. Clin. Endocrinol. Metabol. 84, 18861891.
  • Dodson R. & Gorski R. A. (1993). Testosterone propionate administration prevents the loss of neurons within the central part of the medial preoptic nucleus. J. Neurobiol. 24, 8088.
  • Dubal D., Shughrue P., Wilson M., Merchenthaler I., Wise P. (1999) Estradiol modulates Bcl-2 in cerebral ischemia: a potential role for estrogen receptors. J. Neurosci. 19, 63856393.
  • Finkelstein M., Weidenfeld J., Ne'Eman Y., Samuni A., Mizrachi Y., Ben-Uzilio R. (1981) Comparative studies of the aromatization of testosterone and epitestosterone by human placental aromatase. Endocrinology 108, 943947.
  • Finley S. K. & Kritzer M. F. (1999) Immunoreactivity for intracellular androgen receptors in identified subpopulations of neurons, astrocytes and oligodendrocytes in primate prefrontal cortex. J. Neurobiol. 40, 446457.
  • Flood J. F., Farr S. A., Kaiser F. E., La Regina M., Morley J. E. (1995) Age-related decrease of plasma testosterone in SAMP8 Mice: Replacement improves age-related Impairment of learning and memory. Physiol. Behav. 57, 669673.
  • Gelfand M. (1992) Estrogen-androgen hormone replacement therapy. In: Hormone replacement therapy. (Swartz D., ed.) Williams & Wilkins, Baltimore, 221234.
  • Goodman Y. & Mattson M. P. (1996) Ceramide protects hippocampal neurons against excitotoxic and oxidative insults, and amyloid β-peptide toxicity. J. Neurochem. 66, 869872.
  • Gouras G. K., Xu H., Gross R. S., Greenfield J. P., Hai B., Wang R., Greengard P. (2000) Testosterone reduces neuronal secretion of Alhzeimer's β-amyloid peptides. Proc. Natl Acad. Sci. USA 97, 12021205.
  • Green P. S. & Simpkins J. W. (2000) Neuroprotective effects of estrogens: potential mechanisms of action. Int. J. Dev Neurosci 18, 347358.
  • Green P. S., Bishop J., Simpkins J. W. (1997) 17 alpha-estradiol exerts neuroprotective effects on SK-N-SH cells. J. Neurosci 17, 511515.
  • Harlow E. & Lane D. (1988) Immunoprecipitations. Antibodies, A laboratory manual. Cold Spring Harbor Laboratories, New York, 421466.
  • Jaffe A. B., Toran-Allerand C. D., Greenyard P., Gandy S. E. (1994) Estrogen regulates metabolism of Alzheimer amyloid β precursor protein. J. Biol. Chem. 269, 1306513068.
  • Jorm A. F., Korten A. E., Henderson A. S. (1987) The Prevalence of dementia: a quantitative integration of the literature. Acta Psychiatr. Scand. 76, 465479.
  • Kaufman M., Pinsky L., Trifiro M., Lumbroso R., Sabbaghian N., Gottlieb B. (1993) Kinetic evidence for a unique testosterone-receptor complex in 5α-reductase sufficient genital skin fibroblasts and the effects of 5α-reductase deficiency on its formation. J. Steroid Biochem. Molec. Biol. 45, 467476.
  • Labrie F. (1993) Mechanism of action and pure antiandrogenic properties of flutamide. Cancer 72, 38163827.
  • LeBlanc A. C. (1995) Increased production of 4 kDa amyloid β peptide in serum deprived human primary neuron cultures: possible involvement of apoptosis. J. Neurosci. 15, 78377846.
  • Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J. (1951) Protein replacement with the Folin phenol reagent. J. Biol. Chem. 193, 265275.
  • McEwen B. S. & Woolley C. S. (1994) Estradiol and progesterone regulate neuronal structure and synaptic connectivity in adult as well as developing brain. Exp Gerontol. 29, 431436.
  • McEwen B. S., Tanapat P., Weiland N. G. (1999) Inhibition of dendritic spine induction on hippocampal CA1 pyramidal neurons by a nonsteroidal estrogen antagonist in female rats. Endocrinology 140, 10441047.
  • Maggi R., Poletti A., Casulari L. A., Pimpinelli F., Piva F., Zanisi M. R., Martini L. (1998) Effects and metabolism of steroid hormones in human neuroblastoma cells. Steroids 63, 257262.
  • Markiewicz L. & Gurpide E. (1997) Estrogenic and progestagenic activities of physiologic and synthetic androgens, as measured by in vitro bioassays. Meth Find Exp. Clin. Pharmacol. 19, 215222.
  • Molsa P. K., Marttila R. J., Rinne U. K. (1982) Epidemiology of dementia in a Finnish population. Acta Neurol. Scand. 65, 541552.
  • Moosmann B. & Behl C. (1999) The antioxidant neuroprotective effects of estrogens and phenolic compounds are independent from their estrogenic properties. Proc. Natl Acad. Sci. USA 96, 88678872.
  • Mulnard R. A., Cotman C. W., Kawas C., Van Dyck C. H., Sano M., Doody R., Koss E., Pfeiffer E., Jin S., Gamst A., Grundman M., Thomas R., Thal L. (2000) Estrogen replacement therapy for treatment of mild to moderate Alzheimer Disease. JAMA 283, 10071015.
  • Namer M. (1988) Clinical applications of antiandrogens. J. Steroid Biochem. 31, 719729.
  • Nuck B. A. & Lucky A. W. (1987) Epitestosterone: a potential new antiandrogen. J. Invest. Dermatol. 89, 209211.
  • Paganini-Hill A. (1996) Oestrogen replacement therapy and Alzheimer's disease. Br. J. Obstet. Gyn. 103, 8086.
  • Pike C. (1999) Estrogen Modulates Neuronal Bcl-x expression and β-Amyloid-Induced Apoptosis: Relevance to Alzheimer's Disease. J. Neurochem. 72, 15521563.
  • Puy L., MacLusky N. J., Becker L., Karsan N., Trachtenberg J., Brown T. J. (1995) Immunocytochemical detection of androgen receptor in human temporal cortex: characterization and application of polyclonal androgen receptor antibodies in frozen and paraffin-embedded tissues. J. Steroid Biochem. Molec. Biol. 55, 197209.
  • Rako S. (1998) Testosterone deficiency: a key factor in the increased cardiovascular risk to women following hysterectomy or with natural aging. J. Women's Health 7, 825829.
  • Schneider L. S., Farlow M. R., Henderson V. W., Pogoda J. M. (1996) Effects of estrogen replacement therapy on response to tacrine in patients with Alzheimer's disease. Neurology 46, 15801584.
  • Schneider L. S., Farlow M. R., Pogoda J. M. (1997) Potential Role for Estrogen Replacement in the Treatment of Alzheimer's Dementia. Am. J. Med. 103, 46S50S.
  • Simard J., Luthy I., Guay J., Belanger A., Labrie F. (1986) Characteristics of interaction of the antiandrogen flutamide with the androgen receptor in various target tissues. Mol. Cell. Endocrinol. 44, 261270.
  • Simpkins J. W., Green P. S., Gridley K. E., Singh M., De Fiebre N. C., Rajakumar G. (1997) The role of estrogen replacement therapy in memory enhancement and the prevention of neuronal loss associated with Alzheimer's. Am. J. Med. 103, 19S25S.
  • Singh M., Setalo G. Jr, Guan X., Warren M., Toran-Allerand C. D. (1999) Estrogen-induced activation of mitogen-activated protein kinase in cerebral cortical explants: convergence of estrogen and neurotrophin signaling pathways. J. Neurosci 19, 11791188.
  • Singh S. M., Gauthier S., Labrie F. (2000a) Androgen receptor antagonists (antiandrogens): structure-activity relationships. Curr. Med. Chem. 7, 211247.
  • Singh M., Setalo G., Guan X., Frail D. E., Toran-Allerand D. (2000b) Estrogen-induced activation of the mitogen-activated protein kinase cascade in the cerebral cortex of estrogen receptor-α knock out mice. J. Neurosci.. 20, 16941700.
  • Starka L., Bicikova M., Hampl R. (1989) Epitestosterone – an endogenous antiandrogen? J. Steroid Biochem. 33, 10191021.
  • Starka L., Hampl R., Bicikova M., Jelinek R., Doskocil M. (1991) Observations on the biological activity of epitestosterone. Physiol. Res. 40, 317326.
  • Sternbach H. (1998) Age-associated testosterone decline in men: clinical issues for psychiatry. Am. J. Psychiatry 155, 13101318.
  • Tang M. X., Jacobs D., Stern Y., Marder K., Schofield P., Gurland B., Andrews H., Mayeux R. (1996) Effect of oestrogen during menopause on risk and age of onset of Alzheimer's disease. Lancet 348, 429432.
  • Tirassa P., Thiblin I., Agren G., Vigneti E., Aloe L., Stenfors C. (1997) High-dose anabolic steroids modulate concentration of nerve growth factor and expression of its low affinity receptor (p75-NGFr) in male rat brain. J. Neurosci. Res. 47, 198207.
  • Tohgi H., Utsugisawa K., Yamagata M., Yoshimura M. (1995) Effects of age on messenger RNA expression of glucocorticoid, thyroid hormone, androgen, and estrogen receptors in postmortem human hippocampus. Brain Res. 700, 245253.
  • Toran-Allerand C. D. (2000a) Estrogen as a treatment for Alzheimer disease. JAMA 284, 307308.
  • Toran-Allerand C. D. (2000b) Novel sites and mechanisms of oestrogen action in the brain. Novartis Found. Symp. 230, 5669. discussion 69–73.
  • Traish A. M., Muller R. E., Wotiz H. H. (1986) Binding of 7 alpha, 17 alpha-dimethyl-19-nortestosterone (mibolerone) to androgen and progesterone receptors in human and animal tissues. Endocrinology 118, 13271333.
  • Turcotte G., Chapdelaine A., Roberts K. D., Chevalier S. (1988) Androgen binding as evidenced by a whole cell assay system using cultured canine prostatic epithelial cells. J. Steroid Biochem. 29, 6976.
  • Vermeulen A. (1991) Androgens in the aging male. J. Clin. Endocrinol. Metabolism. 73, 221224.
  • Wade S. B., Oommen P., Conner W. C., Earnest D. J., Miranda R. C. (1999) Overlapping and divergent actions of estrogen and the neurotrophins on cell fate and p53-dependent signal transduction in conditionally immortalized cerebral cortical neuroblasts. J. Neurosci. 19, 69947006.
  • Wiita B., Artis A., Ackerman D. M., Longcope C. (1995) Binding of 17-alpha-methyltestosterone in vitro to human sex hormone binding globulin and rat ventral prostate androgen receptors. Ther. Drug Monit. 17, 377380.
  • Wilson E. M. & French F. S. (1976) Binding properties of androgen receptors. Evidence for identical receptors in rat testis, epididymis, and prostate. J. Biol. Chem. 251, 56205629.
  • Woolley C. S. (1999) Effects of estrogen in the CNS. Curr. Opin. Neurobiol. 9, 349354.
  • Woolley C. S. & McEwen B. S. (1993) Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat. J. Comp. Neurol. 336, 293306.
  • Woolley C. S. & McEwen B. S. (1994) Estradiol regulates hippocampal dendritic spine density via an N-methyl-d-aspartate receptor-dependent mechanism. J. Neurosci. 14, 76807687.
  • Woolley C. S., Weiland N. G., McEwen B. S., Schwartzkroin P. A. (1997) Estradiol increases the sensitivity of hippocampal CA1 pyramidal cells to NMDA receptor-mediated synaptic input: correlation with dendritic spine density. J. Neurosci. 17, 18481859.
  • Wright A. F., Goedert M., Hastie N. D. (1991) Familial Alzheimer's disease – Beta-amyloid resurrected. Nature 349, 653654.
  • Xu H., Gouras G., Greenfield J., Voncent B., Nalsund J., Mazzarelli L., Fried G., Jovanovic J., Seeger M., Relkin N., Liao F., Checler F., Buxbaum J., Chait B., Thinakaran G., Sisodia S., Wang R., Greengard P., Gandy S. (1998) Estrogen reduces neuronal generation of Alzheimer β-amyloid peptides. Nat. Med. 4, 447451.
  • Zhang Y., Goodyer C., LeBlanc A. (2000) Selective and protracted apoptosis in human primary neurons microinjected with active caspase-3, 6, 7 and 8. J. Neurosci. 20, 83848389.