• Please log in or register to access this feature.
You have full text access to this OnlineOpen article

Measurement of β-hydroxybutyrate in acute hyperketonemia in human brain

  1. J. W. Pan1,
  2. F. W. Telang2,
  3. J. H. Lee2,
  4. R. A. De Graaf3,
  5. D. L. Rothman3,
  6. D. T. Stein1,
  7. H. P. Hetherington1

Article first published online: 7 JUL 2008

DOI: 10.1046/j.1471-4159.2001.00575.x

Issue

Journal of Neurochemistry

Journal of Neurochemistry

Volume 79, Issue 3, pages 539–544, November 2001

Additional Information

How to Cite

Pan, J. W., Telang, F. W., Lee, J. H., De Graaf, R. A., Rothman, D. L., Stein, D. T. and Hetherington, H. P. (2001), Measurement of β-hydroxybutyrate in acute hyperketonemia in human brain. Journal of Neurochemistry, 79: 539–544. doi: 10.1046/j.1471-4159.2001.00575.x

Author Information

  1. 1

    Albert Einstein College of Medicine, Bronx, New York, USA

  2. 2

    Brookhaven National Laboratory, Upton, New York, USA

  3. 3

    Yale University School of Medicine, New Haven, Connecticut, USA

*Address correspondence and reprint requests to J.W. Pan, Department of Neurology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York, NY 10461, USA. E-mail: jpan@aecom.yu.edu

Publication History

  1. Issue published online: 7 JUL 2008
  2. Article first published online: 7 JUL 2008
  3. Received June 29, 2001; revised manuscript received August 6, 2001; accepted August 7, 2001.

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (221K)

References

  • Balasse E. O. & Fery F. (1985) Ketone body production and disposal in diabetic ketosis. a comparison with fasting ketosis. Diabetes 34, 326–332.
  • Barton R. N. (1973) The interconversion and disposal of ketone bodies in untreated and injured post-absorptive rats. Biochem. J. 136, 531–543.
  • Corddry D. H., Rapoport S. I., London E. D. (1982) No effect of hyperketonemia on local cerebral glucose utilization in conscious rat. J. Neurochem. 38, 1637–1641.
    Direct Link:
  • Gjedde A. & Crone C. (1975) Induction processes in blood–brain transfer of ketone bodies during starvation. Am. J. Physiol. 229, 1165–1169.
  • Hasselbalch S. G., Knudsen G. M., Jakobsen J., Hageman L. P., Holm S., Paulson O. B. (1994) Brain metabolism during short term starvation in humans. J. Cereb. Blood Flow Metab. 14, 125–131.
  • Hasselbalch S. G., Knudsen G. M., Jakobsen J., Hageman L. P., Holm S., Paulson O. B. (1995) Blood brain barrier permeability of glucose and ketone bodies during short-term starvation in humans. Am. J. Physiol. 268, E1161–E1166.
  • Hasselbalch S. G., Madsen P. L., Hageman L. P., Olsen K. S., Justesen N., Holm S., Paulson O. B. (1996) Changes in cerebral blood flow and carbohydrate metabolism during acute hyperketonemia. Am. J. Physiol. 270, E746–E751.
  • Hawkins R. A., Williamson D. H., Krebs H. A. (1971) Ketone body utilization by adult and suckling rat brain in vivo. Biochem. J. 122, 13–18.
  • Hawkins R. A., Mans A. M., Davis D. W. (1986) Regional ketone body utilization by rat brain in starvation and diabetes. Am. J. Physiol. 250, E169–E178.
  • Lamers K. J. B., Doesburg W. H., Gabreels F. J. M., Romsom A. C., Lemmens W. A., Wevers R. A., Renier W. O. (1987) CSF: concentration and CSF/blood ratio of fuel related components in children after prolonged fasting. Clin. Chim. Acta 167, 135–145.
  • Oldendorf W. H. (1973) Carrier mediated blood brain barrier transport of short chain monocarboxylic organic acids. Am. J. Physiol. 224, 1450–1453.
  • Owen O. E., Morgan A. P., Kemp H. G., Sullivan J. M., Herrera M. G., Cahill J. F. (1967) Brain metabolism during fasting. J. Clin. Invest. 46, 1589–1595.
  • Pan J. W., Twieg D. B., Hetherington H. P. (1998) Quantitative spectroscopic imaging of the human brain. Magn. Reson. Med. 40, 363–369.
    Direct Link:
  • Pan J. W., Rothman D. L., Behar K. L., Stein D. T., Hetherington H. P. (2000a) Human brain β-hydroxybutyrate and lactate increase in fasting induced ketosis. J. Cereb. Blood Flow Metab. 20, 1502–1507.
  • Pan J. W., Stein D. T., Telang F., Lee J. H., Shen J., Brown P., Cline G., Mason G. F., Shulman G. I., Rothman D. L., Hetherington H. P. (2000b) Spectroscopic imaging of glutamate C4 turnover in human brain. Magn. Reson. Med. 44, 673–679.
    Direct Link:
  • Robinson A. M. & Williamson D. H. (1980) Physiological role of ketone bodies as substrates and signals in mammalian tissues. Physiol. Rev. 60, 143–187.
  • Ruderman N. B., Ross P. S., Berger M., Goodman M. N. (1974) Regulation of glucose and ketone body metabolism in brain of anesthetized rats. Biochem. J. 138, 1–10.
  • Sammi M. K., Pan J. W., Telang F., Volkow N. D., Hetherington H. P. (2001) Spectral editing: use of a selective inversion pulse in an adiabatic double spin echo sequence. Proc Int. Soc. Magn. Reson. Med. abstract 1668.
  • Veneman T., Mitrakou A., Mokan M., Cryer P., Gerich J. (1994) Effect of hyperketonemia and hyperlacticacidemia on symptoms, cognitive dysfunction and counterregulatory hormone responses during hypoglycemia in normal humans. Diabetes 43, 1311–1317.
View Full Article (HTML) Get PDF (221K)