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Characterization of GTP cyclohydrolase I gene expression in the human neuroblastoma SKN-BE(2)M17: enhanced transcription in response to cAMP is conferred by the proximal promoter
Article first published online: 7 JUL 2008
DOI: 10.1046/j.1471-4159.2001.00583.x
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How to Cite
Hirayama, K., Shimoji, M., Swick, L., Meyer, A. and Kapatos, G. (2001), Characterization of GTP cyclohydrolase I gene expression in the human neuroblastoma SKN-BE(2)M17: enhanced transcription in response to cAMP is conferred by the proximal promoter. Journal of Neurochemistry, 79: 576–587. doi: 10.1046/j.1471-4159.2001.00583.x
Publication History
- Issue published online: 7 JUL 2008
- Article first published online: 7 JUL 2008
- Received July 10, 2001; revised manuscript received August 8, 2001; accepted August 9, 2001.
References
- , , , , (1978) Biopterin content of human neuroblastoma cells in culture. Biochem. Biophys. Res. Com. 19, 377–380.
- , , , , , (1998) Vasoactive intestinal peptide induces both tyrosine hydroxylase activity and tetrahydrobiopterin biosynthesis in PC12 cells. Neuroscience 86, 179–189.DOI: 10.1016/s0306-4522(97)00611-8
- , , (1997) The rat arylalkylamine N-acetyltransferase gene promoter – cAMP activation via a cAMP-responsive element–CCAAT complex. J. Biol. Chem. 272, 6979–6985.
- , , , , , , , , (1997) A common mechanism underlying the E1A repression and the cAMP stimulation of the H ferritin transcription. J. Biol. Chem. 272, 20736–20741.DOI: 10.1074/jbc.272.33.20736
- , , , (1978) Multiple neurotransmitter synthesis by human neuroblastoma cell lines and clones. Cancer Res. 38, 3751–3757.
- (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248–254.DOI: 10.1006/abio.1976.9999
- , , , (1988) Human CCAAT-binding proteins have heterologous subunits. Cell 53, 11–24.
- (1997) Functional interaction between the DNA binding subunit trimerization domain of NF-Y and the high mobility group protein HMG-I (Y). J. Biol. Chem. 272, 30880–30888.
- , , , (1997) GTP cyclohydrolase-I like immunoreactivity in rat brain. Brain Res. 777, 187–201.
- , , (1983) Accurate transcription initiation by RNA polymerase-II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11, 1475–1488.
- , , , , (1999) Complexes containing activating transcription factor (ATF) /cAMP-responsive-element-binding protein (CREB) interact with the CCAAT enhancer-binding protein (C/EBP)-ATF composite site to regulate Gadd153 expression during the stress response. Biochem. J. 339, 135–141.
- & (2001) Transcriptional activation of the small GTPase gene rhoB by genotoxic stress is regulated via a CCAAT element. Nucleic Acids Res. 29, 792–798.DOI: 10.1093/nar/29.3.792
- & (1980) Analysis of reduced forms of biopterin in biological tissues and fluids. Anal. Biochem. 102, 176–188.
- , , , , , (2001) GTP cyclohydrolase I mRNA: novel splice variants in the slime mould Physarum polycephalum and in human monocytes (THP-1) indicate conservation of mRNA processing. Biochem. J. 355, 499–507.DOI: 10.1042/0264-6021:3550499
- , , , (1995) Transcription factor ATF2 regulation by the JNK signal-transduction pathway. Science 267, 389–393.
- , , , , (1992) Species and tissue-specificity of mammalian GTP cyclohydrolase-I messenger-RNA. Biochim. Biophys. Acta 1171, 133–140.
- & (1991) Cross-family dimerization of transcription factors Fos Jun and ATF CREB alters DNA-binding specificity. Proc. Natl. Acad. Sci. USA 88, 3720–3724.
- , , (1992) IMP dehydrogenase inhibitors reduce intracellular tetrahydrobiopterin levels through reduction of intracellular GTP levels – indications of the regulation of GTP cyclohydrolase-I activity by restriction of GTP availability in the cells. J. Biol. Chem. 267, 20734–20739.
- , , , , , (1998) Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL. Nucleic Acid Res. 26, 364–370.
- , , (1997) Differential splicing of the GTP cyclohydrolase I RNA in dopa-responsive dystonia. Biochem. Biophys. Res. Commun. 234, 316–319.
- & (1995) Regulation of GTP cyclohydrolase-I gene-expression and tetrahydrobiopterin content by nerve growth factor in cultures of superior cervical-ganglia. Neurochem. Int. 27, 157–161.
- & (1998) Nigrostriatal dopamine neurons express low levels of GTP cyclohydrolase I protein. J. Neurochem. 70, 164–170.
- , , (1993) Tetrahydrobiopterin cofactor biosynthesis; GTP cyclohydrolase I mRNA expression in rat brain and superior cervical ganglia. J. Neurochem. 61, 1006–1014.
- , , , , , , , , , (1995) Characterization of mouse and human GTP cyclohydrolase-I genes – mutations in patients with GTP cyclohydrolase-I deficiency. J. Biol. Chem. 270, 10062–10071.
- , , (1991) Molecular characterization of transcription factors that bind to the cAMP responsive region of the substance-P precursor gene – cDNA cloning of a novel C/EBP-related factor. J. Biol. Chem. 266, 15525–15531.
- , , , (1981) Biosynthesis of biopterin: adrenergic cyclic adenosine monophosphate-dependent inhibition in the pineal gland. Science 213, 1129–1131.
- , , , (1999) GTP cyclohydrolase I feedback regulatory protein is expressed in serotonin neurons and regulates tetrahydrobiopterin biosynthesis. J. Neurochem. 72, 669–675.DOI: 10.1046/j.1471-4159.1999.0720669.x
- , , (2000) Identification and characterization of basal and cyclic AMP response elements in the promoter of the rat GTP cyclohydrolase I gene. J. Biol. Chem. 275, 5947–5957.DOI: 10.1074/jbc.275.8.5947
- (1974) Properties of the pterin-dependent aromatic amino acid hydroxylases. In: CIBA Foundation Symposium, Vol. 22: Aromatic Amino Acids in the Brain, pp. 85–115. Amsterdam: Elsevier.
- , , , , , , (2000) ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation. Nature 405, 195–200.
- , , (1974) In vivo enhancement of tyrosine hydroxylation in rat striatum by tetrahydrobiopterin. Nature 249, 476–478.
- , , (1989) Reduced biopterin as a cofactor in the generation of nitrogen-oxides by murine macrophages. J. Biol. Chem. 264, 20496–20501.
- & (1996) Tetrahydrobiopterin biosynthesis in the rat brain: heterogeneity of GTP cyclohydrolase I mRNA expression in monoamine-containing neurons. Neurochem. Int. 28, 569–582.DOI: 10.1016/0197-0186(95)00124-7
- , , , , (1992) Intron-exon organization of the NF-Y genes – tissue-specific splicing modifies an activation domain. J. Biol. Chem. 267, 8984–8990.
- & (1977) A new method of sequencing DNA. Proc. Natl. Acad. Sci. USA 74, 560–564.
- , , (1985) 6R–l-erythro-5,6,7,8-tetrahydrobiopterin as a regulator of dopamine and serotonin biosynthesis in the rat-brain. Arch. Biochem. Biophys. 239, 234–241.
- (1997) Transcriptional regulation by cyclic AMP. Annu. Rev. Biochem. 66, 807–822.
- , , (1992) Interaction of the-170-cyclic AMP response element with the adjacent CCAAT box in the human fibronectin gene promoter. J. Biol. Chem. 267, 12767–12774.
- , , , , , (1995) Immunocytochemical localization of GTP cyclohydrolase I in the brain, adrenal gland, and liver of mice. J. Neural Transm. 102, 175–188.
- , , , , , (1999) Specific localization of the guanosine triphosphate (GTP) cyclohydrolase I-immunoreactivity in the human brain. J. Neural Transm. 106, 607–617.DOI: 10.1007/s007020050183
- , , (1985) Biosynthesis and metabolism of tetrahydrobiopterin and molybdopterin. Annu. Rev. Biochem. 54, 729–764.
- , , , , , , (1993) Cloning and sequencing of cDNA-encoding mouse GTP cyclohydrolase-I. Biochem. Biophys. Res. Commun. 191, 523–527.
- , , , (1996) Identification and characterization of basal and cyclic AMP response elements in the promoter of the rat hexokinase II genes. J. Biol. Chem. 271, 17296–17303.
- , , , , (1996) Interleukin 1 beta and cAMP trigger the expression of GTP cyclohydrolase I in rat renal mesangial cells. Biochem. J. 318, 665–671.
- , , , (1999) GTP cyclohydrolase I gene expression in the brains of male and female hph-1 mice. J. Neurochem. 72, 757–764.
- , , , , (1996) Glucocorticoids regulate inducible nitric oxide synthase by inhibiting tetrahydrobiopterin synthesis and 1-arginine transport. J. Biol. Chem. 271, 23928–23937.
- , , , (1995) Recombinant rat CBF-C, the 3rd subunit of CBF/NFY, allows formation of a protein-DNA complex with CBF-A and CBF-B and with yeast HAP2 and HAP3. Proc. Natl. Acad. Sci. USA 92, 1624–1628.
- , , , , (1993) The CRE-binding factor ATF-2 facilitates the occupation of the CCAAT box in the fibronectin gene promoter. FEBS Lett. 327, 25–28.
- , , (1996) Regulation of GTP cyclohydrolase I gene expression and tetrahydrobiopterin content in cultured sympathetic neurons by leukemia inhibitory factor and ciliary neurotrophic factor. J. Neurochem. 66, 2541–2545.
- & (1989) Macrophage oxidation of 1-arginine to nitric-oxide, nitrite, and nitrate – tetrahydrobiopterin is required as a cofactor. J. Biol. Chem. 264, 19654–19685.
- , , , , (1992) Multiple messenger-RNA forms of human GTP cyclohydrolase-I. Biochem. Biophys. Res. Commun. 187, 359–365.
- , , , , , , , (1990) Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts. J. Exp. Med. 172, 1599–1607.
- , , , , , , , , (1996) Cloning, sequencing and functional studies of the gene encoding human GTP cyclohydrolase I. Gene 171, 285–290.
- , , (1994) Regulation of tetrahydrobiopterin biosynthesis in cultured dopamine neurons by depolarization and cAMP. J. Biol. Chem. 269, 11825–11829.

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