Intermediate filaments regulate astrocyte motility
Article first published online: 7 JUL 2008
Journal of Neurochemistry
Volume 79, Issue 3, pages 617–625, November 2001
How to Cite
Lepekhin, E. A., Eliasson, C., Berthold, C.-H., Berezin, V., Bock, E. and Pekny, M. (2001), Intermediate filaments regulate astrocyte motility. Journal of Neurochemistry, 79: 617–625. doi: 10.1046/j.1471-4159.2001.00595.x
- Issue published online: 7 JUL 2008
- Article first published online: 7 JUL 2008
- Received June 21, 2001; revised manuscript received August 8, 2001; accepted August 15, 2001.
- glial fibrillary acidic protein (GFAP);
- intermediate filaments;
Intermediate filaments (IFs) compose, together with actin filaments and microtubules, the cytoskeleton and they exhibit a remarkable but still enigmatic cell-type specificity. In a number of cell types, IFs seem to be instrumental in the maintenance of the mechanical integrity of cells and tissues. The function of IFs in astrocytes has so far remained elusive. We have recently reported that glial scar formation following brain or spinal cord injury is impaired in mice deficient in glial fibrillary acidic protein and vimentin. These mice lack IFs in reactive astrocytes that are normally pivotal in the wound repair process. Here we show that reactive astrocytes devoid of IFs exhibit clear morphological changes and profound defects in cell motility thereby revealing a novel function for IFs.