• Corringer P. J., Le Novere N., Changeux J. P. (2000) Nicotinic receptors at the amino acid level. Annu. Rev. Pharmacol. Toxicol. 40, 431458.
  • Grenningloh G., Schmieden V., Schofield P. R., Seeburg P. H., Siddique T., Mohandas T. K., Becker C. M., Betz H. (1990) Alpha subunit variants of the human glycine receptor: primary structures, functional expression and chromosomal localization of the corresponding genes. EMBO J. 9, 771776.
  • Harvey R. J., Thomas P., James C. H., Wilderspin A., Smart T. G. (1999) Identification of an inhibitory Zn2+ binding site on the human glycine receptor α1 subunit. J. Physiol. (Lond.) 520, 5364.
  • Karlin A. & Akabas M. H. (1998) Substituted-cysteine accessibility method. Meth. Enzymol. 293, 123145.
  • Kuhse J., Betz H., Kirsch J. (1995) The inhibitory glycine receptor: architecture, synaptic localization and molecular pathology of a postsynaptic ion-channel complex. Curr. Opin. Neurobiol. 5, 318323.
  • Langosch D., Thomas L., Betz H. (1988) Conserved quaternary structure of ligand-gated ion channels: the postsynaptic glycine receptor is a pentamer. Proc. Natl Acad. Sci. USA 85, 73947398.
  • Langosch D., Laube B., Rundstrom N., Schmieden V., Bormann J., Betz H. (1994) Decreased agonist affinity and chloride conductance of mutant glycine receptors associated with human hereditary hyperekplexia. EMBO J. 13, 42234228.
  • Laube B., Kuhse J., Betz H. (2000) Kinetic and mutational analysis of Zn2+ modulation of recombinant human inhibitory glycine receptors. J. Physiol. (Lond.) 522, 215230.
  • Lewis T. M., Sivilotti L. G., Colquhoun D., Gardiner R. M., Schoepfer R., Rees M. (1998) Properties of human glycine receptors containing the hyperekplexia mutation α1 (K276E), expressed in Xenopus oocytes. J. Physiol. (Lond.) 507, 2540.
  • Lynch J. W., Rajendra S., Pierce K. D., Handford C. A., Barry P. H., Schofield P. R. (1997) Identification of intracellular and extracellular domains mediating signal transduction in the inhibitory glycine receptor chloride channel. EMBO J. 16, 110120.
  • Lynch J. W., Han N. L. R., Haddrill J., Pierce K. D., Schofield P. R. (2001) The surface accessibility of the glycine receptor M2–M3 loop is increased in the channel open state. J. Neurosci. 21, 25892599.
  • Maksay G., Laube B., Betz H. (1999) Selective blocking effects of tropisetron and atropine on recombinant glycine receptors. J. Neurochem. 73, 802806.
  • Pascual J. M. & Karlin A. (1998) State-dependent accessibility and electrostatic potential in the channel of the nicotinic acetylcholine receptor: inferences from rates of reaction of thiosulfonates with substituted cysteines in the M2 segment of the alpha subunit. J. Gen. Physiol. 111, 717739.
  • Rajendra S., Lynch J. W., Pierce K. D., French C. R., Barry P. H., Schofield P. R. (1994) Startle disease mutations reduce the agonist sensitivity of the human inhibitory glycine receptor. J. Biol. Chem. 269, 1873918742.
  • Rajendra S., Vandenberg R. J., Pierce K. D., Cunningham A. C., French P. W., Barry P. H., Schofield P. R. (1995a) The unique disulfide loop of the glycine receptor is a principle ligand binding element. EMBO J. 14, 29872998.
  • Rajendra S., Lynch J. W., Pierce K. D., French C. R., Barry P. H., Schofield P. R. (1995b) Mutation of an arginine residue in the human glycine receptor transforms β-alanine and taurine from agonists into antagonists. Neuron 14, 169175.
  • Rajendra S., Lynch J. W., Schofield P. R. (1997) The glycine receptor. Pharmacol. Ther. 73, 121146.DOI: 10.1016/s0163-7258(96)00163-5
  • Ryan S. G., Buckwalter M. S., Lynch J. W., Handford C. A., Segura L., Shiang R., Wasmuth J. J., Camper S. A., Schofield P. R., O'Connell P. (1994) A missense mutation in the gene encoding the α1 subunit of the inhibitory glycine receptor causes the spasmodic mouse phenotype. Nat. Genet. 7, 131135.
  • Saul B., Schmieden V., Kling C., Mulhardt C., Gass P., Kuhse J., Becker C. M. (1994) Point mutation of glycine receptor α1 subunit in the spasmodic mouse affects agonist responses. FEBS Lett. 350, 7176.
  • Schmieden V. & Betz H. (1995) Pharmacology of the inhibitory glycine receptor: agonist and antagonist actions of amino acids and piperidine carboxylic acid compounds. Mol. Pharmacol. 48, 919927.
  • Schmieden V., Kuhse J., Betz H. (1992) Agonist pharmacology of neonatal and adult glycine receptor α subunits: identification of amino acid residues involved in taurine activation. EMBO J. 11, 20252032.
  • Schmieden V., Kuhse J., Betz H. (1993) Mutation of glycine receptor subunit creates β-alanine receptor sensitive to GABA. Science 262, 256258.
  • Schmieden V., Kuhse J., Betz H. (1999) A novel domain of the inhibitory glycine receptor determining antagonist efficacies: further evidence for partial agonism resulting from self-inhibition. Mol. Pharmacol. 56, 464472.
  • Vafa B., Lewis T. M., Cunningham A. C., Jacques P., Lynch J. W., Schofield P. R. (1999) Identification of a new ligand binding domain in the α1 subunit of the inhibitory glycine receptor. J. Neurochem. 73, 21582166.
  • Vandenberg R. J., French C. R., Barry P. H., Shine J., Schofield P. R. (1992a) Antagonism of ligand-gated ion channel receptors: two domains of the glycine receptor α subunit form the strychnine binding site. Proc. Natl Acad. Sci. USA 89, 17651769.
  • Vandenberg R. J., Handford C. A., Schofield P. R. (1992b) Distinct agonist- and antagonist-binding sites on the glycine receptor. Neuron 9, 491496.