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  • Arsenijevic D., Onuma H., Pecqueur C., Raimbault S., Manning B. S., Miroux B., Couplan E., Alves-Guerra M. C., Goubern M., Surwit R., Bouillaud F., Richard D., Collins S., Ricquier D. (2000) Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nat. Genet. 26, 435439.
  • Beal M. F. (1992) Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illness? Ann. Neurol. 31, 119130.
  • Becker G. L., Fiskum G., Lehninger A. L. (1980) Regulation of free Ca2+ by liver mitochondria and endoplasmic reticulum. J. Biol. Chem. 255, 90099012.
  • Benov L., Sztejnberg L., Fridovich I. (1998) Critical evaluation of the use of hydroethidine as a measure of superoxide anion radical. Free Rad. Biol. Med. 25, 826831.
  • Bindokas V. P., Jordan J., Lee C. C., Miller R. J. (1996) Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine. J. Neurosci. 16, 13241336.
  • Boss O., Samec S., Paoloni-Giacobino A., Rossier C., Dulloo A., Seydoux J., Muzzin P., Giacobino J. P. (1997) Uncoupling protein-3. a new member of the mitochondrial carrier family with tissue-specific expression. FEBS Lett. 408, 3942.DOI: 10.1016/s0014-5793(97)00384-0
  • Brand M. D., Chien L. F., Ainscow E. K., Rolfe D. F., Porter R. K. (1994) The causes and functions of mitochondrial proton leak. Biochim. Biophys. Acta 1187, 132139.
  • Budd S. L., Castilho R. F., Nicholls D. G. (1997) Mitochondrial membrane potential and hydroethidine-monitored superoxide generation in cultured cerebellar granule cells. FEBS Lett. 415, 2124.
  • Dugan L. L., Bruno V. M. G., Amagasu S. M., Giffard R. G. (1995) Glia modulate the response of murine cortical neurons to excitotoxicity: glia exacerbate AMPA neurotoxicity. J. Neurosci. 15, 45454555.
  • Echtay K. S., Winkler E., Klingenberg M. (2000) Coenzyme Q is an obligatory cofactor for uncoupling protein function. Nature 408, 609613.
  • Echtay K. S., Winkler E., Frischmuth K., Klingenberg M. (2001) Uncoupling proteins 2 and 3 are highly active H (+) transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone). Proc. Natl Acad. Sci. USA 98, 14161421.
  • Enerback S., Jacobsson A., Simpson E. M., Guerra C., Yamashita H., Harper M. E., Kozak L. P. (1997) Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature 387, 9094.
  • Fleury C., Neverova M., Collins S., Raimbault S., Champigny O., Levi-Meyrueis C., Bouillaud F., Seldin M. F., Surwit R. S., Ricquier D., Warden C. H. (1997) Uncoupling protein-2. a novel gene linked to obesity and hyperinsulinemia. Nat. Genet. 15, 269272.
  • Fujimura M., Morita-Fujimura Y., Kawase M., Copin J. C., Calagui B., Epstein C. J., Chan P. H. (1999) Manganese superoxide dismutase mediates the early release of mitochondrial cytochrome C andsubsequent DNA fragmentation after permanent focal cerebral ischemia in mice. J. Neurosci. 19, 34143422.
  • Gonzalez-Barroso M. M., Fleury C., Bouillaud F., Nicholls D. G., Rial E. (1998) The uncoupling protein UCP1 does not increase the proton conductance of the inner mitochondrial membrane by functioning as a fatty acid anion transporter. J. Biol. Chem. 273, 1552815532.DOI: 10.1074/jbc.273.25.15528
  • Jung C., Higgins C. M., Xu Z. (2000) Measuring the quantity and activity of mitochondrial electron transport chain complexes in tissues of central nervous system using blue native polyacrylamide gel electrophoresis. Anal. Biochem. 286, 214223.
  • Klingenberg M. & Echtay K. S. (2001) Uncouplng proteins. the issues from a biochemist point of view. Biochem. Biophys. Acta 1504, 128143.
  • Kowaltowski A. J., Smail S. S., Russell J. T., Fiskum G. (2000) Elevation of resting mitochondrial membrane potential of neural cells by cyclosporin A, BAPTA-AM, and Bcl-2. Am. J. Physiol. 279, C852C859.
  • Mao W., Yu X. X., Zhong A., Li W., Brush J., Sherwood S. W., Adams S. H., Pan G. (1999) UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells. FEBS Lett. 443, 326330.DOI: 10.1016/s0014-5793(98)01713-x
  • Melov S., Coskun P. E., Wallace D. C. (1999) Mouse models of mitochondrial disease, oxidative stress, and senescence. Mutat. Res. 434, 233242.
  • Moreadith R. W. & Fiskum G. (1984) Isolation of mitochondria from ascites tumor cells permeabilized with digitonin. Anal. Biochem. 137, 360367.
  • Murphy A. N., Bredesen D. E., Cortopassi G., Wang E., Fiskum G. (1996) Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria. Proc. Natl Acad. Sci. USA 93, 98939898.
  • Negre-Salvayre A., Hirtz C., Carrera G., Cazenave R., Troly M., Salvayre R., Penicaud L., Casteilla L. (1997) A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation. FASEB J. 11, 809815.
  • Neupert W. (1994) Heinrich Wieland prize lecture. Transport of proteins across mitochondrial membranes. Clin. Invest. 72, 251261.
  • Nicholls D. G. (1977) Cellular mechanisms in brown fat thermogenesis mitochondria. Experientia 33, 11301131.
  • Nicholls D. G. & Locke R. M. (1984) Thermogenic mechanisms in brown fat. Physiol. Rev. 64, 164.
  • Nishikawa T., Du Edelstein D. X. L., Yamagishi S., Matsumura T., Kaneda Y., Yorek M. A., Beebe D., Oates P. J., Hammes H. P., Giardino I., Brownlee M. (2000) Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 404, 787790.
  • Pecqueur C., Alves-Guerra M. C., Gelly C., Levi-Meyrueis C., Couplan E., Collins S., Ricquier D., Bouillaud F., Miroux B. (2001a) Uncoupling protein 2, in vivo distribution, induction upon oxidative stress, and evidence for translational regulation. J. Biol. Chem. 276, 87058712.
  • Pecqueur C., Couplan E., Bouillaud F., Ricquier D. (2001b) Genetic and physiological analysis of the role of uncoupling proteins in human energy homeostasis. J. Mol Med. 79, 4856.
  • Rapoport S. I., Hatanpaa K., Brady D. R., Chandrasekaran K. (1996) Brain energy metabolism, cognitive function and down-regulated oxidative phosphorylation in Alzheimer's disease. Neurodegeneration 5, 473476.DOI: 10.1006/neur.1996.0065
  • Rial E. & Gonzalez-Barroso M. M. (2001) Physiological regulation of the transport activity in the uncoupling proteins UCP1 and UCP2. Biochim. Biophys. Acta 1504, 7081.
  • Ricquier D. & Bouillaud F. (2000) The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP. Biochem. J. 345, 161179.
  • Rolfe D. F., Newman J. M., Buckingham J. A., Clark M. G., Brand M. D. (1999)Contribution of mitochondrial proton leak to respiration rate in working skeletal muscle and liver and to SMR.Am. J. Physiol.276, C692C699.
  • Rothwell N. J. & Stock M. J. (1979)A role for brown adipose tissue in diet-induced thermogenesis.Nature281, 3135.
  • Sanchis D., Fleury C., Chomiki N., Goubern M., Huang Q., Neverova M., Gregoire F., Easlick J., Raimbault S., Levi-Meyrueis C., Miroux B., Collins S., Seldin M., Richard D., Warden C., Bouillaud F., Ricquier D. (1998) BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast. J. Biol. Chem. 273, 3461134615.DOI: 10.1074/jbc.273.51.34611
  • Skulachev V. P. (1998) Uncoupling. new approaches to an old problem of bioenergetics. Biochim. Biophys. Acta. 1363, 100124.
  • Stuart J. A., Cadenas S., Jekabsons M. B., Roussel D., Brand M. D. (2001) Mitochondrial proton leak and the uncoupling protein 1 homologues. Biochim. Biophys. Acta 1504, 144158.
  • Vidal-Puig A. J., Grujic D., Zhang C. Y., Hagen T., Boss O., Ido Y., Szczepanik A., Wade J., Mootha V., Cortright R., Muoio D. M., Lowell B. B. (2000) Energy metabolism in uncoupling protein 3 gene knockout mice. J. Biol. Chem. 275, 1625816266.
  • Wallace D. C. (1999) Mitochondrial diseases in man and mouse. Science 283, 14821488.
  • Ward M. W., Rego A. C., Frenguelli B. G., Nicholls D. G. (2000)Mitochondrial membrane potential and glutamate excitotoxicity in cultured cerebellar granule cells.J. Neurosci.20, 72087219.
  • Weber F. E., Minestrini G., Dyer J. H., Werder M., Boffelli D., Compassi S., Wehrli E., Thomas R. M., Schulthess G., Hauser H. (1997) Molecular cloning of a peroxisomal Ca2+-dependent member of the mitochondrial carrier superfamily. Proc. Natl Acad. Sci. USA 94, 85098514.
  • Winkler E., Heidkaemper D., Klingenberg M., Liu Q., Caskey T. (2001) UCP3 expressed in yeast is primarily localized in extramitochondrial particles. Biochem. Biophys. Res. Commun. 282, 334340.DOI: 10.1006/bbrc.2001.4563
  • Yu X. X., Mao W., Zhong A., Schow P., Brush J., Sherwood S. W., Adams S. H., Pan G. (2000) Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation. FASEB J. 14, 16111618.
  • Zhou J., Holtzman D. M., Weiner R. I., Mobley W. C. (1994) Expression of TrkA confers neuron-like responsiveness to nerve growth factor on an immortalized hypothalamic cell line. Proc. Natl Acad. Sci. USA 91, 38243828.