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  • Almer G., Guegan C., Teismann P., Naini A., Rosoklija G., Hays A. P., Chen C. and Przedborski S. (2001) Increased expression of the pro-inflammatory enzyme cyclooxygenase-2 in amyotrophic lateral sclerosis. Ann. Neurol. 49, 176185.
  • Andreassen O. A., Ferrante R. J., Klivenyi P., Klein A. M., Shinobu L. A., Epstein C. J. and Beal M. F. (2000) Partial deficiency of manganese superoxide dismutase exacerbates a transgenic mouse model of amyotrophic lateral sclerosis. Ann. Neurol. 47, 447455.
  • Baker K., Marcus C. B., Huffman K., Kruk H., Malfroy B. and Doctrow S. R. (1998) Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: a key role for reactive oxygen species in ischemic brain injury. J. Pharmacol. Exp. Ther. 284, 215221.
  • Beal M. F. (1992) Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses? Ann. Neurol. 31, 119130.
  • Bittigau P. and Ikonomidou C. (1997) Glutamate in neurologic diseases. J. Child Neurol. 12, 471485.
  • Borthwick G. M., Johnson M. A., Ince P. G., Shaw P. J. and Turnbull D. M. (1999) Mitochondrial enzyme activity in amyotrophic lateral sclerosis: implications for the role of mitochondria in neuronal cell death. Ann. Neurol. 46, 787790.
  • Bowling A. C., Schulz J. B., Brown R. H. Jr and Beal M. F. (1993) Superoxide dismutase activity, oxidative damage and mitochondrial energy metabolism in familial and sporadic amyotrophic lateral sclerosis. J. Neurochem. 61, 23222325.
  • Bratton S. B. and Cohen G. M. (2001) Apoptotic death sensor: an organelle's alter ego? Trends Pharmacol. Sci. 22, 306315.
  • Browne S. E., Bowling A. C., Baik M. J., Gurney M., Brown R. H. Jr and Beal M. F. (1998) Metabolic dysfunction in familial, but not sporadic, amyotrophic lateral sclerosis. J. Neurochem. 71, 281287.
  • Canton T., Pratt J., Stutzmann J. M., Imperato A. and Boireau A. (1998) Glutamate uptake is decreased tardively in the spinal cord of FALS mice. Neuroreport 9, 775778.
  • Carri M. T., Ferri A., Battistoni A., Famhy L., Cabbianelli R., Poccia F. and Rotilio G. (1997) Expression of a Cu,Zn superoxide dismutase typical of familial amyotrophic lateral sclerosis induces mitochondrial alteration and increase of cytosolic Ca2+ concentration in transfected neuroblastoma SH-SY5Y cells. FEBS Lett. 414, 365368.
  • Carriedo S. G., Yin H. Z. and Weiss J. H. (1996) Motor neurons are selectively vulnerable to AMPA/kainate receptor-mediated injury in vitro. J. Neurosci. 16, 40694079.
  • Carriedo S. G., Sensi S. L., Yin H. Z. and Weiss J. H. (2000) AMPA exposures induce mitochondrial Ca(2+) overload and ROS generation in spinal motor neurons in vitro. J. Neurosci. 20, 240250.
  • Cleveland D. W. and Rothstein J. D. (2001) From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS. Nat. Rev. Neurosci. 2, 806819.
  • Dal Canto M. C. and Gurney M. E. (1995) Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu, Zn SOD, and in mice overexpressing wild type human SOD: a model of familial amyotrophic lateral sclerosis (FALS). Brain Res. 676, 2540.
  • Estevez A. G., Crow J. P., Sampson J. B., Reiter C., Zhuang Y. X., Richardson G. J., Tarpey M. M., Barbeito L. and Beckman J. S. (1999) Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase. Science 286, 24982500.
  • Estornell E., Fato R., Pallotti F. and Lenaz G. (1993) Assay conditions for the mitochondrial NADH: coenzyme Q oxidoreductase. FEBS Lett. 332, 127131.
  • Fujita K., Yamauchi M., Shibayama K., Ando M., Honda M. and Nagata Y. (1996) Decreased cytochrome c oxidase activity but unchanged superoxide dismutase and glutathione peroxidase activities in the spinal cords of patients with amyotrophic lateral sclerosis. J. Neurosci. Res. 45, 276281.
  • Gurney M. E., Pu H., Chiu A. Y., Dal Canto M. C., Polchow C. Y., Alexander D. D., Caliendo J., Hentati A., Kwon Y. W., Deng H.-X., Chen W., Zhai P., Sufit R. L. and Siddique T. (1994) Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase. Science 264, 17721775.
  • Gurney M. E., Fleck T. J., Himes C. S. and Hall E. D. (1998) Riluzole preserves motor function in a transgenic model of familial amyotrophic lateral sclerosis. Neurology 50, 6266.
  • Higgins C. M., Jung C., Ding H. and Xu Z. (2002) Mutant Cu,Zn superoxide dismutase that causes motoneuron degeneration is present in mitochondria in the CNS. J. Neurosci. 22, RC215.
  • Howland D. S., Liu J., She Y., Goad B., Maragakis N. J., Kim B., Erickson J., Kulik J., DeVito L., Psaltis G. et al. (2002) Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS). Proc. Natl Acad. Sci. USA 99, 16041609.
  • Ikonomidou C. and Turski L. (1996) Neurodegenerative disorders: clues from glutamate and energy metabolism. Crit. Rev. Neurobiol. 10, 239263.
  • Ikonomidou C., Qin Qin Y., Labruyere J. and Olney J. W. (1996) Motor neuron degeneration induced by excitotoxin agonists has features in common with those seen in the SOD-1 transgenic mouse model of amyotrophic lateral sclerosis. J. Neuropathol. Exp. Neurol. 55, 211224.
  • Jaarsma D., Rognoni F., Van Duijn W., Verspaget H. W., Haasdijk E. D. and Holstege J. C. (2001) CuZn superoxide dismutase (SOD1) accumulates in vacuolated mitochondria in transgenic mice expressing amyotrophic lateral sclerosis-linked SOD1 mutations. Acta Neuropathol. (Berl.) 102, 293305.
  • Johnston J. A., Dalton M. J., Gurney M. E. and Kopito R. R. (2000) Formation of high molecular weight complexes of mutant Cu, Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis. Proc. Natl Acad. Sci. USA 97, 1257112576.
  • Julien J. P. (2001) Amyotrophic lateral sclerosis: unfolding the toxicity of the misfolded. Cell 104, 581591.
  • Jung C., Higgins C. M. J. and Xu Z. S. (2000) Measuring the quantity and activity of mitochondrial electron transport chain complexes in tissues of central nervous system using blue native polyacrylamide gel electrophoresis. Anal. Biochem. 286, 214223.
  • Jung C., Higgins C. M. and Xu Z. (2002) A quantitative histochemical assay for activities of mitochondrial electron transport chain complexes in mouse spinal cord sections. J. Neurosci. Methods 114, 165172.
  • Kaal E. C., Vlug A. S., Versleijen M. W., Kuilman M., Joosten E. A. and Bar P. R. (2000) Chronic mitochondrial inhibition induces selective motoneuron death in vitro: a new model for amyotrophic lateral sclerosis. J. Neurochem. 74, 11581165.
  • Klivenyi P., Ferrante R. J., Matthews R. T., Bogdanov M. B., Klein A. M., Andreassen O. A., Mueller G., Wermer M., Kaddurah-Daouk R. and Beal M. F. (1999) Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis. Nat. Med. 5, 347350.
  • Kong J. and Xu Z. (1998) Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1. J. Neurosci. 18, 32413250.
  • Kostic V., Jackson-Lewis V., De Bilbao F., Dubois-Dauphin M. and Przedborski S. (1997) Bcl-2: prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis. Science 277, 559562.
  • Kruman I. I., Pedersen W. A., Springer J. E. and Mattson M. P. (1999) ALS-linked Cu/Zn-SOD mutation increases vulnerability of motor neurons to excitotoxicity by a mechanism involving increased oxidative stress and perturbed calcium homeostasis. Exp. Neurol. 160, 2839.
  • Levine J. B., Kong J., Nadler M. and Xu Z. (1999) Astrocytes interact intimately with degenerating motor neurons in mouse amyotrophic lateral sclerosis (ALS). Glia 28, 215224.
  • Li M., Ona V. O., Gueacutegan C., Chen M., Jackson-Lewis V., Andrews L. J., Olszewski A. J., Stieg P. E., Lee J.-P., Przedborski S. and Friedlander R. M. (2000) Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model. Science 288, 335339.
  • Martin L. J. (1999) Neuronal death in amyotrophic lateral sclerosis is apoptosis: possible contribution of a programmed cell death mechanism. J. Neuropathol. Exp. Neurol. 58, 459471.
  • Mourelatos Z., Gonatas N. K., Stieber A., Gurney M. E. and Dal Canto M. C. (1996) The Golgi apparatus of spinal cord motor neurons in transgenic mice expressing mutant Cu,Zn superoxide dismutase becomes fragmented in early, preclinical stages of the disease. Proc. Natl Acad. Sci. USA 93, 54725477.
  • Okado-Matsumoto A. and Fridovich I. (2001) Subcellular distribution of superoxide dismutases (SOD) in rat liver: Cu,Zn-SOD in mitochondria. J. Biol. Chem. 276, 3838838393.
  • Pasinelli P., Houseweart M. K., Brown R. H. Jr, Cleveland D. W. and Borchelt D. R. (2000) Caspase-1 and -3 are sequentially activated in motor neuron death in Cu,Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis. Proc. Natl Acad. Sci. USA 97, 1390113906.
  • Pedersen W. A., Fu W., Keller J. N., Markesbery W. R., Appel S., Smith R. G., Kasarskis E. and Mattson M. P. (1998) Protein modification by the lipid peroxidation product 4-hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients. Ann. Neurol. 44, 819824.
  • Rosen D. R., Siddique T., Patterson D., Figlewicz D. A., Sapp P., Hentati A., Donaldson D., Goto J., O'Regan J. P., Deng H.-X. et al. (1993) Mutations in Cu,Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 362, 5962.
  • Rothstein J. D. (1996) Therapeutic horizon for amyotrophic lateral sclerosis. Curr. Opin. Neurobiol. 6, 679687.
  • Rothstein J. D., Kuncl R., Chaudhry V., Clawson L., Cornblath D. R., Coyle J. T. and Drachman D. B. (1991) Excitatory amino acids in amyotrophic lateral sclerosis: an update. Ann. Neurol. 30, 224225.
  • Rothstein J. D., Jin L., Dykes-Hoberg M. and Kuncl R. W. (1993) Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity. Proc. Natl. Acad. Sci. USA 90, 65916595.
  • Rothstein J. D., Dykes-Hoberg M., Pardo C. A., Bristol L. A., Jin L., Kuncl R. W., Kanai Y., Hediger M. A., Wang Y., Schielke J. P. et al. (1996) Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron 16, 675686.
  • Rowland L. P. and Shneider N. A. (2001) Amyotrophic lateral sclerosis. N. Eng. J. Med. 344, 16881700.
  • Schagger H. (1996) Electrophoretic techniques for isolation and quantification of oxidative phosphorylation complexes from human tissues. Methods Enzymol. 264, 555566.
  • Sekuzu I., Mizushima H., Hirota S., Yubisui T., Matsumura Y. and Okunuki K. (1967) Studies on cytochrome oxidase of yeast. I. Purification and enzymatic activity of cytochrome oxidase from saccharomyces oviformis M2. J. Biochem. (Tokyo) 62, 710718.
  • Seligman A. M., Karnovsky M. J., Wasserkrug H. L. and Hanker J. S. (1968) Nondroplet ultrastructural demonstration of cytochrome oxidase activity with a polymerizing osmiophilic reagent, diaminobenzidine (DAB). J. Cell Biol. 38, 114.
  • Stout A. K., Raphael H. M., Kanterewicz B. I., Klann E. and Reynolds I. J. (1998) Glutamate-induced neuron death requires mitochondrial calcium uptake. Nat. Neurosci. 1, 366373.
  • Sturtz L. A., Diekert K., Jensen L. T., Lill R. and Culotta V. C. (2001) A fraction of yeast Cu,Zn-superoxide dismutase and its metallochaperone, CCS, localize to the intermembrane space of mitochondria. A physiological role for SOD1 in guarding against mitochondrial oxidative damage. J. Biol. Chem. 276, 3808438089.
  • Swerdlow R. H., Parks J. K., Cassarino D. S., Trimmer P. A., Miller S. W., Maguire D. J., Sheehan J. P., Maguire R. S., Pattee G., Juel V. C., Philips L. H., Tuttle J. B. J. P., Bennett J., Davis R. E. and Parker W. D. Jr (1998) Mitochondria in sporadic amyotrophic lateral sclerosis. Exp. Neurol. 153, 135142.
  • Trotti D., Rolfs A., Danbolt N. C., Brown R. H. Jr and Hediger M. A. (1999) SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter [published erratum appears in Nat. Neurosci. 1999, 2, 848]. Nat. Neurosci. 2, 427433.
  • Trounce I. A., Kim Y. L., Jun A. S. and Wallace D. C. (1996) Assessment of mitochondrial oxidative phosphorylation in patient muscle biopsies, lymphoblasts, and transmitochondrial cell lines. Methods Enzymol. 264, 484509.
  • Vandenberghe W., Ihle E. C., Patneau D. K., Robberecht W. and Brorson J. R. (2000) AMPA receptor current density, not desensitization, predicts selective motoneuron vulnerability. J. Neurosci. 20, 71587166.
  • Vielhaber S., Kunz D., Winkler K., Wiedemann F. R., Kirches E., Feistner H., Heinze H. J., Elger C. E., Schubert W., Kunz W. S. et al. (2000) Mitochondrial DNA abnormalities in skeletal muscle of patients with sporadic amyotrophic lateral sclerosis. Impairment of mitochondrial function in skeletal muscle of patients with amyotrophic lateral sclerosis. Brain 123, 13391348.
  • Weisiger R. A. and Fridovich I. (1973) Mitochondrial superoxide simutase. Site of synthesis and intramitochondrial localization. J. Biol. Chem. 248, 47934796.
  • Wiedau-Pazos M., Goto J. J., Rabizadeh S., Gralla E. B., Roe J. A., Lee M. K., Valentine J. S. and Bredesen D. E. (1996) Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis. Science 271, 515518.
  • Wiedemann F. R., Winkler K., Kuznetsov A. V., Bartels C., Vielhaber S., Feistner H. and Kunz W. S. (1998) Impairment of mitochondrial function in skeletal muscle of patients with amyotrophic lateral sclerosis. J. Neurol. Sci. 156, 6572.
  • Wiedemann F. R., Manfredi G., Mawrin C., Beal M. F. and Schon E. A. (2002) Mitochondrial DNA and respiratory chain function in spinal cords of ALS patients. J. Neurochem. 80, 616625.
  • Wong P. C., Pardo C. A., Borchelt D. R., Lee M. K., Copeland N. G., Jenkins N. A., Sisodia S. S., Cleveland D. W. and Price D. L. (1995) An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron 14, 11051116.
  • Xu Z. (2000) Mechanism and treatment of motoneuron degeneration in ALS: what have SOD1 mutants told us? ALS 1, 225234.
  • Yim H. S., Kang J. H., Chock P. B., Stadtman E. R. and Yim M. B. (1997) A familial amyotrophic lateral sclerosis-associated A4V Cu, Zn-superoxide dismutase mutant has a lower Km for hydrogen peroxide. Correlation between clinical severity and the Km value. J. Biol. Chem. 272, 88618863.