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References

  • Appleton D. B. and DeVivo D. C. (1974) An animal model for the ketogenic diet. Epilepsia 15, 211227.
  • Baumann R. J. (1982) Classification and population studies of epilepsy, in Genetic Basis of the Epilepsies (AndersonV. E., HauserW. A., PenryJ. K. and SingC. F., eds), pp. 11–20. Raven Press, New York.
  • Berkovic S. F. (1998) Genetics of epilepsy syndromes, in Epilepsy: a Comprehensive Textbook (EngelJ. and PedleyT. A., eds), pp. 217224. Lippincott-Raven, Philadelphia.
  • Bhagavan N. V. (2002) Medical Biochemistry, 4th Edn. p. 1016. Harcourt, New York.
  • Birt D. F., Yaktine A. and Duysen E. (1999) Glucocorticoid mediation of dietary energy restriction inhibition of mouse skin carcinogenesis. J. Nutr. 129, 571S574S.
  • Bough K. J., Chen R. S. and Eagles D. A. (1999a) Path analysis shows that increasing ketogenic ratio, but not beta-hydroxybutyrate, elevates seizure threshold in the Rat. Dev. Neurosci. 21, 400406.
  • Bough K. J., Valiyil R., Han F. T. and Eagles D. A. (1999b) Seizure resistance is dependent upon age and calorie restriction in rats fed a ketogenic diet. Epilepsy Res. 35, 2128.
  • Brown R. O., Orr C. D., Hanna D. L., Williams J. E. and Dickerson R. N. (2002) Topiramate and weight loss in patients with neurodevelopmental disabilities. Pharmacotherapy 22, 831835.
  • Browne T. R. and Holmes G. L. (2001) Epilepsy. N. Engl. J. Med. 344, 11451151.
  • Chugani H. T. and Chugani D. C. (1999) Basic mechanisms of childhood epilepsies: studies with positron emission tomography. Adv. Neurol. 79, 883891.
  • Clarke D. D. and Sokoloff L. (1999) Circulation and energy metabolism of the brain, in Basic Neurochemistry: Molecular, Cellular and Medical Aspects, 6th Edn (SiegelG. J., AgranoffB. W., AlbersR. W., FisherS. K. and UhlerM. D., eds), pp. 637669. Lippincott-Raven, New York.
  • Cornford E. M., Nguyen E. V. and Landaw E. M. (2000) Acute upregulation of blood–brain barrier glucose transporter activity in seizures. Am. J. Physiol. Heart Circ. Physiol. 279, H1346H1354.
  • Cornford E. M., Shamsa K., Zeitzer J. M., Enriquez C. M., Wilson C. L., Behnke E. J., Fried I. and Engel J. (2002) Regional analyses of CNS microdialysate glucose and lactate in seizure patients. Epilepsia 43, 13601371.
  • Cremer J. E., Braun L. D. and Oldendorf W. H. (1976) Changes during development in transport processes of the blood–brain barrier. Biochim. Biophys. Acta 448, 633637.
  • Cremer J. E., Cunningham V. J., Pardridge W. M., Braun L. D. and Oldendorf W. H. (1979) Kinetics of blood–brain barrier transport of pyruvate, lactate and glucose in suckling, weanling and adult rats. J. Neurochem. 33, 439445.
  • Cullingford T. E., Eagles D. A. and Sato H. (2002) The ketogenic diet upregulates expression of the gene encoding the key ketogenic enzyme mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in rat brain. Epilepsy Res. 49, 99107.
  • Daikhin Y. and Yudkoff M. (1998) Ketone bodies and brain glutamate and GABA metabolism. Dev. Neurosci. 20, 358364.
  • DeVivo D. C., Leckie M. P., Ferrendelli J. S. and McDougal D. B. Jr (1978) Chronic ketosis and cerebral metabolism. Ann. Neurol. 3, 331337.
  • Dhahbi J. M., Mote P. L., Wingo J., Rowley B. C., Cao S. X., Walford R. L. and Spindler S. R. (2001) Caloric restriction alters the feeding response of key metabolic enzyme genes. Mech. Ageing Dev. 122, 10331048.
  • Dimitriadis G., Tegos C., Golfinopoulou L., Roboti C. and Raptis S. (1993) Furosemide-induced hyperglycaemia: the implication of glycolytic kinases. Horm. Metab. Res. 25, 557559.
  • Duan W., Guo Z., Jiang H., Ware M., Li X. J. and Mattson M. P. (2003) Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice. Proc. Natl Acad. Sci. USA 100, 29112916.
  • During M. J., Fried I., Leone P., Katz A. and Spencer D. D. (1994) Direct measurement of extracellular lactate in the human hippocampus during spontaneous seizures. J. Neurochem. 62, 23562361.
  • Dwyer D. S., Vannucci S. J. and Simpson I. A. (2002) Expression, regulation, and functional role of glucose transporters (GLUTs) in brain. Int. Rev. Neurobiol. 51, 159188.
  • Eadie M. J. and Bladin P. F. (2001) A Disease Once Sacred: A History of the Medical Understanding of Epilepsy, p. 248. John Libby, Eastleigh.
  • Engel J. J. and Pedley T. A. (1997) Introduction. What is epilepsy?, in Epilepsy, A Comprehensive Textbook, Vol. 1 (EnglelJ. J. and PedleyT. A., eds), pp. 110. Lipponcott-Raven, New York.
  • Erecinska M., Nelson D., Daikhin Y. and Yudkoff M. (1996) Regulation of GABA level in rat brain synaptosomes: fluxes through enzymes of the GABA shunt and effects of glutamate, calcium, and ketone bodies. J. Neurochem. 67, 23252334.
  • Flavin H. J. and Seyfried T. N. (1994) Enhanced aspartate release related to epilepsy in (EL) mice. J. Neurochem. 63, 592595.
  • Flavin H. J., Wieraszko A. and Seyfried T. N. (1991) Enhanced aspartate release from hippocampal slices of epileptic (El) mice. J. Neurochem. 56, 10071011.
  • Fredericks M. and Ramsey R. B. (1978) 3-Oxo acid coenzyme A transferase activity in brain and tumors of the nervous system. J. Neurochem. 31, 15291531.
  • Freeman J. M., Freeman J. B. and Kelly M. T. (2000) The Ketogenic Diet: A Treatment for Epilepsy, 3rd Edn, p. 236. Demos, New York.
  • Gjedde A. and Crone C. (1975) Induction processes in blood-brain transfer of ketone bodies during starvation. Am. J. Physiol. 229, 11651169.
  • Greene A. E., Todorova M. T., McGowan R. and Seyfried T. N. (2001) Caloric restriction inhibits seizure susceptibility in epileptic EL mice by reducing blood glucose. Epilepsia 42, 13711378.
  • Greenspan R. J. (2001) The flexible genome. Nat. Rev. Genet. 2, 383387.
  • Guzman M. and Blazquez C. (2001) Is there an astrocyte-neuron ketone body shuttle? Trends Endocrinol. Metab. 12, 169173.
  • Hauser W. A. (1997) Incidence and prevalence, in Epilepsy: A Comprehensive Textbook, Vol. 1 (EngelJ. J. and PedleyT. A., eds), pp. 4757. Lippincott-Raven, New York.
  • Haymond M. W., Howard C., Ben-Galim E. and DeVivo D. C. (1983) Effects of ketosis on glucose flux in children and adults. Am. J. Physiol. 245, E373E378.
  • Hesdorffer D. C., Stables J. P., Hauser W. A., Annegers J. F. and Cascino G. (2001) Are certain diuretics also anticonvulsants? Ann. Neurol. 50, 458462.
  • Hochman D. W., Baraban S. C., Owens J. W. and Schwartzkroin P. A. (1995) Dissociation of synchronization and excitability in furosemide blockade of epileptiform activity. Science 270, 99102.
  • Hochman D. W., D'Ambrosio R., Janigro D. and Schwartzkroin P. A. (1999) Extracellular chloride and the maintenance of spontaneous epileptiform activity in rat hippocampal slices. J. Neurophysiol. 81, 4959.
  • Ikemoto A., Bole D. G. and Ueda T. (2003) Glycolysis and glutamate accumulation into synaptic vesicles. Role of glyceraldehyde phosphate dehydrogenase and 3-phosphoglycerate kinase. J. Biol. Chem. 278, 59295940.
  • Janigro D. (1999) Blood–brain barrier, ion homeostatis and epilepsy: possible implications towards the understanding of ketogenic diet mechanisms. Epilepsy Res. 37, 223232.
  • Kadekaro M., Ito M. and Gross P. M. (1988) Local cerebral glucose utilization is increased in acutely adrenalectomized rats. Neuroendocrinology 47, 329334.
  • Kaur G. and Kaur K. (1990) Effect of acute starvation on monoamine oxidase and Na+,K(+)-ATPase activity in rat brain. Mol. Chem. Neuropathol. 13, 175183.
  • Knowlton R. C., Abou-Khalil B., Sawrie S. M., Martin R. C., Faught R. E. and Kuzniecky R. I. (2002) In vivo hippocampal metabolic dysfunction in human temporal lobe epilepsy. Arch. Neurol. 59, 18821886.
  • Koehler-Stec E. M., Simpson I. A., Vannucci S. J., Landschulz K. T. and Landschulz W. H. (1998) Monocarboxylate transporter expression in mouse brain. Am. J. Physiol. 275, E516E524.
  • Koubova J. and Guarente L. (2003) How does calorie restriction work? Genes Dev. 17, 313321.
  • Kuhl D. E., Engel J. Jr, Phelps M. E. and Selin C. (1980) Epileptic patterns of local cerebral metabolism and perfusion in humans determined by emission computed tomography of 18FDG and 13NH3. Ann. Neurol. 8, 348360.
  • Laterra J., Keep R., Betz A. L. and Goldstein G. W. (1999) Blood–brain–cerebrospinal fluid barriers, in Basic Neurochemistry: Molecular, Cellular and Medical Aspects, 6th Edn (SiegelG. J., AgranoffB. W., AlbersR. W., FisherS. K. and UhlerM. D., eds), pp. 671689. Lippincott-Raven, New York.
  • Lee C. K., Weindruch R. and Prolla T. A. (2000) Gene-expression profile of the ageing brain in mice. Nat. Genet. 25, 294297.
  • Leiderman D. B., Balish M., Bromfield E. B. and Theodore W. H. (1991) Effect of valproate on human cerebral glucose metabolism. Epilepsia 32, 417422.
  • Leino R. L., Gerhart D. Z., Duelli R., Enerson B. E. and Drewes L. R. (2001) Diet-induced ketosis increases monocarboxylate transporter (MCT1) levels in rat brain. Neurochem. Int. 38, 519527.
  • Lennox W. G. (1960) Epilepsy and Related Disorders, Vol. 1, p. 1168. Little, Brown, Boston.
  • Lennox W. G. and Cobb S. (1928) Studies in epilepsy VIII. The clinical effect of fasting. Arch. Neurol. Psychiat. 20, 771779.
  • Li X., Yokono K. and Okada Y. (2000) Phosphofructokinase, a glycolytic regulatory enzyme has a crucial role for maintenance of synaptic activity in guinea pig hippocampal slices. Neurosci. Lett. 294, 8184.
  • Likhodii S. S., Musa K., Mendonca A., Dell C., Burnham W. M. and Cunnane S. C. (2000) Dietary fat, ketosis, and seizure resistance in rats on the ketogenic diet. Epilepsia 41, 14001410.
  • Lin S. J., Kaeberlein M., Andalis A. A., Sturtz L. A., Defossez P. A., Culotta V. C., Fink G. R. and Guarente L. (2002) Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature 418, 344348.
  • Livingston S. (1972) Dietary treatment of epilepsy, in Comprehensive Management of Epilepsy in Infancy, Childhood and Adolescence (LivingstonS., ed.), pp. 378405. Charles C. Thomas, Springfield, IL.
  • Macdonald R. L. (1997) Cellular effects of antiepileptic drugs, in Epilepsy: a Comprehensive Textbook, Vol. 2 (EngelJ. J. and PedleyT. A., eds), pp. 13831392. Lippincott-Raven, New York.
  • Mattson M. P., Duan W., Lee J. and Guo Z. (2001) Suppression of brain aging and neurodegenerative disorders by dietary restriction and environmental enrichment: molecular mechanisms. Mech. Ageing Dev. 122, 757778.
  • Mattson M. P., Duan W. and Guo Z. (2003) Meal size and frequency affect neuronal plasticity and vulnerability to disease: cellular and molecular mechanisms. J. Neurochem. 84, 417431.
  • McIlwain H. (1969) Cerebral energy metabolism and membrane phenomena, in Basic Mechanisms of the Epilepsies (JasperH. H., WardA. A. J. and PopeA., eds), pp. 83103. Little, Brown, Boston.
  • McKenna M. C., Stevenson J. H., Huang X. and Hopkins I. B. (2000) Differential distribution of the enzymes glutamate dehydrogenase and aspartate aminotransferase in cortical synaptic mitochondria contributes to metabolic compartmentation in cortical synaptic terminals. Neurochem. Int. 37, 229241.
  • Meldrum B. and Chapman A. (1999) Epileptic seizures and epilepsy, in Basic Neurochemistry: Molecular, Cellular and Medical Aspects, 6th Edn (SiegelG. J., AgranoffB. W., AlbersR. W., FisherS. K. and UhlerM. D., eds), pp. 755768. Lippincott-Raven, New York.
  • Meric P., Barrere B., Peres M., Gillet B., Berenger G., Beloeil J. C. and Seylaz J. (1994) Effects of kainate-induced seizures on cerebral metabolism: a combined 1H and 31P NMR study in rat. Brain Res. 638, 5360.
  • Mukherjee P., El-Abbadi M. M., Kasperzyk J. L., Ranes M. K. and Seyfried T. N. (2002) Dietary restriction reduces angiogenesis and growth in an orthotopic mouse brain tumour model. Br. J. Cancer 86, 16151621.
  • Nehlig A. and Pereira de Vasconcelos A. (1993) Glucose and ketone body utilization by the brain of neonatal rats. Prog. Neurobiol. 40, 163221.
  • Nordli D. R. Jr and De Vivo D. C. (1997) The ketogenic diet revisited: back to the future. Epilepsia 38, 743749.
  • Ormrod D. and McClellan K. (2001) Topiramate: a review of its use in childhood epilepsy. Paediatr. Drugs 3, 293319.
  • Owen O. E., Morgan A. P., Kemp H. G., Sullivan J. M., Herrera M. G. and Cahill G. F. Jr (1967) Brain metabolism during fasting. J. Clin. Invest. 46, 15891595.
  • Pan J. W., Telang F. W., Lee J. H., De Graaf R. A., Rothman D. L., Stein D. T. and Hetherington H. P. (2001) Measurement of beta-hydroxybutyrate in acute hyperketonemia in human brain. J. Neurochem. 79, 539544.
  • Pan J. W., De Graaf R. A., Rothman D. L. and Hetherington H. P. (2002) 13C-[2,4]-b-hydroxybutyrate metabolism in human brain. J. Neurochem. 81, 45.
  • Pellerin L. and Magistretti P. J. (1994) Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. Proc. Natl Acad. Sci. USA 91, 10 62510 629.
  • Pellerin L., Pellegri G., Martin J. L. and Magistretti P. J. (1998a) Expression of monocarboxylate transporter mRNAs in mouse brain: support for a distinct role of lactate as an energy substrate for the neonatal vs. adult brain. Proc. Natl Acad. Sci. USA 95, 39903995.
  • Pellerin L., Pellegri G., Bittar P. G., Charnay Y., Bouras C., Martin J. L., Stella N. and Magistretti P. J. (1998b) Evidence supporting the existence of an activity-dependent astrocyte-neuron lactate shuttle. Dev. Neurosci. 20, 291299.
  • Peterman M. G. (1925) The ketogenic diet in epilepsy. J. Am. Med. Assoc. 84, 19791983.
  • Peterman M. G. (1928) The ketogenic diet. J. Am. Med. Assoc. 90, 14271429.
  • Porter R. J., Meldrum B. S., Macdonald R. L., Dicter M. A., Dam M., Treiman D. M., Chadwick D., Gram L. and Pedley T. A. (1997) Antiepileptic drugs, in Epilepsy: A Comprehensive Textbook, Vol. 2 (EngelJ. J. and PedleyT. A., eds), pp. 13791670. Lippincott-Raven, New York.
  • Redies C., Hoffer L. J., Beil C., Marliss E. B., Evans A. C., Lariviere F., Marrett S., Meyer E., Diksic M., Gjedde A. et al. (1989) Generalized decrease in brain glucose metabolism during fasting in humans studied by PET. Am. J. Physiol. 256, E805E810.
  • Roslin M. and Kurian M. (2001) The use of electrical stimulation of the vagus nerve to treat morbid obesity. Epilepsy Behav. 2, S11S16.
  • Rutecki P. (1990) Anatomical, physiological, and theoretical basis for the antiepileptic effect of vagus nerve stimulation. Epilepsia 31, S1S6.
  • Sacks D. B. (2001) Carbohydrates, in Tietz Fundamentals of Clinical Chemistry (BurtisC. A. and AshwoodE. R., eds), pp. 427461. W.B. Saunders, New York.
  • Sato K., Kashiwaya Y., Keon C. A., Tsuchiya N., King M. T., Radda G. K., Chance B., Clarke K. and Veech R. L. (1995) Insulin, ketone bodies, and mitochondrial energy transduction. Faseb J. 9, 651658.
  • Schwartzkroin P. A. (1999) Mechanisms underlying the anti-epileptic efficacy of the ketogenic diet. Epilepsy Res. 37, 171180.
  • Schwechter E. M., Veliskova J. and Velisek L. (2003) Correlation between extracellular glucose and seizure susceptibility in adult rats. Ann. Neurol. 53, 91101.
  • Silver I. A. and Erecinska M. (1997) Energetic demands of the Na+/K+ ATPase in mammalian astrocytes. Glia 21, 3545.
  • Sirven J., Whedon B., Caplan D., Liporace J., Glosser D., O'Dwyer J. and Sperling M. R. (1999) The ketogenic diet for intractable epilepsy in adults: preliminary results. Epilepsia 40, 17211726.
  • Spanaki M. V., Siegel H., Kopylev L., Fazilat S., Dean A., Liow K., Ben-Menachem E., Gaillard W. D. and Theodore W. H. (1999) The effect of vigabatrin (gamma-vinyl GABA) on cerebral blood flow and metabolism. Neurology 53, 15181522.
  • Strohman R. (2002) Maneuvering in the complex path from genotype to phenotype. Science 296, 701703.
  • Szekely M. (2000) The vagus nerve in thermoregulation and energy metabolism. Auton. Neurosci. 85, 2638.
  • Theodore W. H., DiChiro G., Margolin R., Fishbein D., Porter R. J. and Brooks R. A. (1986a) Barbiturates reduce human cerebral glucose metabolism. Neurology 36, 6064.
  • Theodore W. H., Bairamian D., Newmark M. E., DiChiro G., Porter R. J., Larson S. and Fishbein D. (1986b) Effect of phenytoin on human cerebral glucose metabolism. J. Cereb. Blood Flow Metab. 6, 315320.
  • Theodore W. H., Bromfield E. and Onorati L. (1989) The effect of carbamazepine on cerebral glucose metabolism. Ann. Neurol. 25, 516520.
  • Thio L. L., Wong M. and Yamada K. A. (2000) Ketone bodies do not directly alter excitatory or inhibitory hippocampal synaptic transmission. Neurology 54, 325331.
  • Ting Y. L. and Degani H. (1993) Energetics and glucose metabolism in hippocampal slices during depolarization: 31P and 13C NMR studies. Brain Res. 610, 1623.
  • Todorova M., Tandon P., Madore R. A., Stafstrom C. E. and Seyfried T. N. (2000) Ketogenic diet inhibits epileptogenesis in EL mice: a genetic model for idiopathic epilepsy. Epilepsia 41, 933940.
  • Todorova M. T., Burwell T. J. and Seyfried T. N. (1999) Environmental risk factors for multifactorial epilepsy in EL mice. Epilepsia 40, 16971707.
  • Veech R. L., Chance B., Kashiwaya Y., Lardy H. A. and Cahill G. F. Jr (2001) Ketone bodies, potential therapeutic uses. IUBMB Life 51, 241247.
  • Vielhaber S., Von Oertzen J. H., Kudin A. F., Schoenfeld A., Menzel C., Biersack H. J., Kral T., Elger C. E. and Kunz W. S. (2003) Correlation of hippocampal glucose oxidation capacity and interictal FDG-PET in temporal lobe epilepsy. Epilepsia 44, 193199.
  • Vining E. P. G. (1997) Ketogenic diet, in Epilepsy: a Comprehensive Textbook, Vol. 2 (EngelJ. J. and PedleyT. A., eds), pp. 13391344. Lippincott-Raven, New York.
  • Waagepetersen H. S., Sonnewald U., Larsson O. M. and Schousboe A. (2001) Multiple compartments with different metabolic characteristics are involved in biosynthesis of intracellular and released glutamine and citrate in astrocytes. Glia 35, 246252.
  • Weindruch R. and Walford R. L. (1988) The Retardation of Aging and Disease by Dietary Restriction, p. 436. Thomas, Springfield, IL.
  • Wheless J. W., Baumgartner J. and Ghanbari C. (2001) Vagus nerve stimulation and the ketogenic diet. Neurol. Clin. 19, 371407.
  • Wilder R. (1921) The effects of ketonemia on the course of epilepsy. Mayo Clinic Proc. 2, 307308.
  • Wolf P. (1994) Historical aspects: the concept of idiopathy, in Idiopathic Generalized Epilepsies: Clinical, Experimental, and Genetic Aspects (MalafosseA., GentonP., HirschE., MarescauxC., BroglinD. and BernasconiR., eds), pp. 36. John Libbey, London.
  • Yudkoff M., Daikhin Y., Nissim I., Grunstein R. and Nissim I. (1997) Effects of ketone bodies on astrocyte amino acid metabolism. J. Neurochem. 69, 682692.
  • Yudkoff M., Daikhin Y., Nissim I., Lazarow A. and Nissim I. (2001) Ketogenic diet, amino acid metabolism, and seizure control. J. Neurosci. Res. 66, 931940.