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  • Ancolio K., Alves da Costa C., Uéda K. and Checler F. (2000) α-synuclein and the Parkinson's disease-related mutant Ala53Thr-α-synuclein do not undergo proteasomal degradation in HEK293 and neuronal cells. Neurosci. Lett. 0, 7982.
  • Baba M., Nakajo S., Tu P.-H., Tomita T., Nakaya K., Lee V. M.-Y., Trojanowski J. Q. and Iwatsubo T. (1998) Aggregation of α-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies. Am. J. Pathol. 152, 879884.
  • Bednarski E., Vanderklish P., Gall C., Saido T. C., Bahr B. A. and Lynch G. (1995) Translational suppression of calpain I reduces NMDA-induced spectrin proteolysis and pathophysiology in cultured hippocampal slices. Brain Res. 694, 147157.
  • Bennett M. C., Bishop J. F., Leng Y., Chock P. B., Chase T. N. and Mouradian M. M. (1999) Degradation of α-synuclein by proteasome. J. Biol. Chem. 274, 3385533858.
  • Billger M., Wallin M. and Karlsson J. O. (1988) Proteolysis of tubulin and microtubule-associated proteins 1 and 2 by calpain I and II. Difference in sensitivity of assembled and disassembled microtubules. Cell Calcium 9, 3344.
  • Cabin D. E., Shimazu K., Murphy D., Cole N. B., Gottschalk W., McIlwain K. L., Orrison B., Chen A., Ellis C. E., Paylor R., Lu B. and Nussbaum R. L. (2002) Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking α-synuclein. J. Neurosci. 22, 87978807.
  • Chung K. K. K., Dawson V. L. and Dawson T. M. (2001) The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disorders. Trends Neurosci. 24, S7S14.
  • Clayton D. F. and George J. M. (1999) Synucleins in synaptic plasticity and neurodegenerative disorders. J. Neurosci. Res. 58, 120129.
  • Conway K. A., Harper J. D. and Lansbury P. T. Jr (1998) Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson's disease. Nat. Med. 4, 13181320.
  • Crowther A., Jakes R., Spillantini M. G. and Goedert M. (1998) Synthetic filaments assembled from C-terminally truncated α-synuclein. FEBS Lett. 436, 309312.
  • Duda J. E., Giasson B. I., Mabon M. E., Lee V. M.-Y. and Trojanowski J. Q. (2002) Concurrence of α-synuclein and tau brain pathology in the Contursi kindred. Acta Neuropathol. 104, 711.
  • El-Agnaf O. M. A., Jakes R., Curran M. D., Middleton D., Ingenito R., Bianchi E., Pessi A., Neill D. and Wallace A. (1998) Aggregates from mutant and wild-type α-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of β-sheet and amyloid-like filaments. FEBS Lett. 440, 7175.
  • Forno L. S. (1996) Neuropathology of Parkinson's disease. J. Neuropathol. Exp. Neurol. 55, 259272.
  • Gafni J. and Ellerby L. M. (2002) Calpain activation in Huntington's disease. J. Neurosci. 22, 48424849.
  • Gai W. P., Yuan H. X., Li X. Q., Power J. T. H., Blumbergs P. C. and Jensen P. H. (2000) In situ and in vitro study of co-localization and segregation of α-synuclein, ubiquitin, and lipids in Lewy bodies. Exp. Neurol. 166, 324333.
  • Galvin J. E., Lee V. M.-Y. and Trojanowski J. Q. (2001) Synucleinopathies. Arch. Neurol. 58, 186190.
  • Giasson B. I., Uryu K., Trojanowski J. Q. and Lee V. M.-Y. (1999) Mutant and wild-type human α-synucleins assemble into elongated filaments with distinct morphologies in vitro. J. Biol. Chem. 274, 76197622.
  • Giasson B. I., Jakes R., Goedert M., Duda J. E., Leight S., Trojanowski J. Q. and Lee V. M.-Y. (2000) A panel of epitope-specific antibodies detects protein domains distributed throughout human α-synuclein in Lewy bodies of Parkinson's disease. J. Neurosci. Res. 59, 528533.
  • Giasson B. I., Murray I. V. J., Trojanowski J. Q. and Lee V. M.-Y. (2001) A hydrophobic stretch of 12 amino acid residues in the middle of α-synuclein is essential for filament assembly. J. Biol. Chem. 276, 23802386.
  • Giasson B. I., Duda J. E., Quinn S. M., Zhang B., Trojanowski J. Q. and Lee V. M.-Y. (2002) Neuronal α-synucleinopathy with severe movement disorder in mice expressing A53T human α-synuclein. Neuron 34, 521533.
  • Gibb W. R. (1989) Dementia and Parkinson's disease. Br. J. Psych. 154, 596614.
  • Guttmann R. P., Baker D. L., Seifert K. M., Cohen A. S., Coulter D. A. and Lynch D. R. (2001) Specific proteolysis of the NR2 subunit at multiple sites by calpain. J. Neurochem. 78, 10831093.
  • Hsu L. J., Mallory M., Xia Y., Veinbergs I., Hashimoto M., Yoshimoto M., Thal L. J., Saitoh T. and Masliah E. (1998) Expression pattern of synucleins (non-Aβ component of Alzheimer's disease amyloid precursor protein/α-synucleins) during murine brain development. J. Neurochem. 71, 338344.
  • Johnson G. V. W. and Guttmann R. P. (1997) Calpains: intact and active? Bioessays 19, 10111018.
  • Kanda S., Bishop J. F., Eglitis M. A., Yang Y. and Mouradian M. M. (2000) Enhanced vulnerability to oxidative stress by α-synuclein mutations and C-terminal truncation. Neuroscience 97, 279284.
  • Krüger R., Kuhn W., Woitalla D., Woitalla D., Graeber M., Kösel S., Przuntek H., Epplen J. T., Schöls L. and Reiss O. (1998) Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease. Nat. Genet. 18, 106108.
  • Lee M. S., Kwon Y. T., Li M., Peng J., Friedlander R. M. and Tsai L.-H. (2000) Neurotoxicity induces cleavage of p35 to p25 by calpain. Nature 405, 360364.
  • Lee M. K., Stirling W., Xu Y., Xu X., Qui D., Mandir A. S., Dawson T. M., Copeland N. G., Jenkins N. A. and Price D. L. (2002) Human α-synuclein-harboring familial Parkinson's disease-linking Ala-53[RIGHTWARDS ARROW]Thr mutation causes neurodegenerative disease with α-synuclein aggregation in transgenic mice. Proc. Natl Acad. Sci. USA 99, 89688973.
  • Liu C.-W., Corboy M. J., DeMartino G. N. and Thomas P. J. (2003) Endoproteolytic activity of the proteasome. Science. 299, 408411.
  • McLean C., Kawamata H. and Hyman B. T. (2001) α-synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons. Neuroscience 104, 901912.
  • McNaught K. S. and Jenner P. (2001) Proteasomal function is impaired in substantia nigra in Parkinson's disease. Neurosci. Lett. 297, 191194.
  • McNaught K. S., Bjorklund L. M., Belizaire R., Isacson O., Jenner P. and Olanow C. W. (2002) Proteasome inhibition causes nigral degeneration with inclusion bodies in rats. Neuroreport 13, 14371441.
  • Melloni E., Michetti M., Salamino F., Sparatore B. and Pontremoli S. (1998) Mechanisms of action of a new component of the Ca2+-dependent proteolytic system in rat brain: the calpain activator. Biochem. Biophys. Res. Comm. 249, 583588.
  • Mercken M., Grynspan F. and Nixon R. A. (1995) Differential sensitivity to proteolysis by brain calpain of adult human tau, fetal human tau and PHF-tau. FEBS Lett. 368, 1014.
  • Murphy D. D., Rueter S. M., Trojanowski J. Q. and Lee V. M.-Y. (2000) Synucleins are developmentally expressed, and α-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons. J. Neurosci. 20, 32143220.
  • Narayanan V. and Scarlata S. (2001) Membrane binding and self-association of α-synucleins. Biochemistry 40, 99279934.
  • Narhi L., Wood S. J., Steavenson S., Jiang Y., Wu G. M., Anafi D., Kaufman S. A., Martin F., Sitney K., Denis P., Louis J.-C., Wypych J., Biere A. L. and Citron M. (1999) Both familial Parkinson's disease mutations accelerate α-synuclein aggregation. J. Biol. Chem. 274, 98439846.
  • Nixon R. A., Saito K. I., Grynspan F., Griffin W. R., Katayama S., Honda T., Mohan P. S., Shea T. B. and Beermann M. (1994) Calcium-activated neutral proteinase (calpain) system in aging and Alzheimer's disease. Ann. NY Acad. Sci. 747, 7791.
  • Paxinou E., Chen Q., Weisse M., Giasson B. I., Norris E. H., Rueter S. M., Trojanowski J. Q., Lee V. M.-Y. and Ischiropoulos H. (2001) Induction of α-synuclein aggregation by intracellular nitrative insult. J.Neurosci. 21, 80538061.
  • Polymeropoulos M. H., Lavedan C., Leroy E., Ide S. E., Dehijia A., Dutra A., Pike B., Root H., Rubenstein J., Boyer R., Stenroos S., Chandrasekharappa S., Athanassiadou A., Papapertropoulos T., Johnson W. G., Lazzarini A. M., Duvoisin R. C., Di Iorio G., Golbe L. I. and Nussbaum R. L. (1997) Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science 276, 20452047.
  • Serpell L. C., Berriman J., Jakes R., Goedert M. and Crowther R. A. (2000) Fiber diffraction of synthetic α-synuclein filaments shows amyloid-like cross-β conformation. Proc. Natl Acad. Sci. USA 97, 48974902.
  • Sharma N., McLean P. J., Kawamata H., Irizarry M. C. and Hyman B. T. (2001) α-Synuclein has an altered conformation and shows a tight intermolecular interaction with ubiquitin in Lewy bodies. Acta Neuropathol. 102, 329334.
  • Sharon R., Goldberg M. S., Bar-Josef I., Betensky R. A., Shen J. and Selkoe D. J. (2001) α-synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins. Proc. Natl Acad. Sci. USA 98, 91109115.
  • Shimura H., Schlossmacher M. G., Hattori N., Frosch M. P., Trockenbacher A., Schneider R., Mizuno Y., Kosik K. S. and Selkoe D. J. (2001) Ubiquitination of a new form of α-synuclein by parkin from human brain: implications for Parkinson's disease. Science 293, 263269.
  • Shtilerman M. D., Ding T. T. and Lansbury P. T. Jr (2002) Molecular crowding accelerates fibrillization of α-synuclein: could an increase in the cytoplasmic protein concentration induce Parkinson's disease? Biochemistry 41, 38553860.
  • Souza J. M., Giasson B. I., Lee V. M.-Y. and Ischiropoulos H. (2000) Chaperone-like activity of synucleins. FEBS Lett. 474, 116119.
  • Spillantini M. G., Crowther R. A., Jakes R., Cairns N. J., Lantos P. L. and Goedert M. (1998a) Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies. Neurosci. Lett. 251, 205208.
  • Spillantini M. G., Crowther R. A., Jakes R., Hasegawa M. and Goedert M. (1998b) α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. U.S.A. 95, 64696473.
  • Tofaris G. K., Layfield R. and Spillantini M. G. (2001) α-Synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome. FEBS Lett. 509, 2226.
  • Uversky V. N. and Fink A. L. (2002) Amino acid determinants of α-synuclein aggregation: putting together pieces of the puzzle. FEBS Lett. 522, 913.
  • Uversky V. N. M., Cooper E., Bower K. S., Li J. and Fink A. L. (2001) Accelerated α-synuclein fibrillation in crowded milieu. FEBS Lett. 515, 99103.
  • Yamazaki T., Haass C., Saido T. C., Omura S. and Ihara Y. (1997) Specific increase in amyloid β-protein 42 secretion ratio by calpain inhibition. Biochemistry 36, 83778383.
  • Yen S., Easson C., Nacharaju P., Hutton M. and Yen S.-H. (1999) FTDP-17 tau mutations decrease the susceptibility of tau to calpain I digestion. FEBS Lett. 461, 9195.