Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms


Address correspondence and reprint requests to Peter Davies Department of Pathology Albert Einstein College of Medicine, 1300 Morris Park Avenue F526, Bronx NY 10461 USA.
E-mail: davies@aecom.yu.edu


Neurofibrillary tangles are composed of insoluble aggregates of the microtubule-associated protein tau. In Alzheimer's disease the accumulation of neurofibrillary tangles occurs in the absence of tau mutations. Here we present mice that develop pathology from non-mutant human tau, in the absence of other exogenous factors, including β-amyloid. The pathology in these mice is Alzheimer-like, with hyperphosphorylated tau accumulating as aggregated paired helical filaments. This pathologic tau accumulates in the cell bodies and dendrites of neurons in a spatiotemporally relevant distribution.