Brain-derived neurotrophic factor shows a protective effect and improves recovery of the ERG b-wave response in light-damage
Version of Record online: 15 SEP 2003
Journal of Neurochemistry
Volume 87, Issue 2, pages 290–296, October 2003
How to Cite
Ikeda, K., Tanihara, H., Tatsuno, T., Noguchi, H. and Nakayama, C. (2003), Brain-derived neurotrophic factor shows a protective effect and improves recovery of the ERG b-wave response in light-damage. Journal of Neurochemistry, 87: 290–296. doi: 10.1046/j.1471-4159.2003.01994.x
- Issue online: 17 SEP 2003
- Version of Record online: 15 SEP 2003
- Received February 21, 2003; revised manuscript received May 5, 2003; accepted June 6, 2003.
- brain-derived neurotrophic factor;
- retinal damage
We investigated the neuroprotective effects of brain-derived neurotrophic factor (BDNF) and its influence on the functional recovery of the retina following light-induced retinal damage by electroretinogram (ERG). Rats were exposed to constant fluorescent light for 2, 5, 7, or 14 days, then returned to a cyclic light environment for 14 days. The result indicated that BDNF had few effects on the a-wave amplitude, but there was a statistically significant difference in the b-wave amplitudes between BDNF-treated and control eyes from day 0–14 of the recovery period following 2 days of light exposure (p < 0.05). Our findings suggest that BDNF not only protects the retinal neuronal function but also enhances the recovery from retinal light damage.