SEARCH

SEARCH BY CITATION

References

  • Alonso A. C., Zaidi T., Grundke-Iqbal I. and Iqbal K. (1994) Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease. Proc. Natl Acad. Sci. USA 0, 55625566.
  • Alonso A. C., Grundke-Iqbal I. and Iqbal K. (1996) Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules. Nat. Med. 2, 783787.
  • Alonso A. D., Grundke-Iqbal I., Barra H. S. and Iqbal K. (1997) Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of microtubule-associated proteins 1 and 2 the disassembly of microtubules by the abnormal tau. Proc. Natl Acad. Sci. USA 94, 298303.
  • Anderton B. H., Brion J. P., Couck A. M. et al. (1995) Modulation of PHF-like tau phosphorylation in cultured neurones and transfected cells. Neurobiol. Aging 16, 389397; discussion 398–402.
  • Arcaro A. and Wymann M. P. (1993) Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses. Biochem. J. 296, 297301.
  • Bennecib M., Gong C. X., Grundke-Iqbal I. and Iqbal K. (2000a) Role of protein phosphatase-2A and -1 in the regulation of GSK-3, cdk5 and cdc2 and the phosphorylation of tau in rat forebrain. FEBS Lett. 485, 8793.
  • Bennecib M., Gong C. X., Wegiel J., Lee M. H., Grundke-Iqbal I. and Iqbal K. (2000b) Inhibition of protein phosphatases and regulation of tau phosphorylation in rat brain. Alzheimer's Reports 3, 295303.
  • Braak E., Braak H. and Mandelkow E. M. (1994) A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads. Acta Neuropathol. 87, 554567.
  • Buxbaum J. D., Koo E. H. and Greengard P. (1993) Protein phosphorylation inhibits production of Alzheimer amyloid β/A4 peptide. Proc. Natl Acad. Sci. USA 90, 91959198.
  • Cook D., Fry M. J., Hughes K., Sumathipala R., Woodgett J. R. and Dale T. C. (1996) Wingless inactivates glycogen synthase kinase-3 via an intracellular signalling pathway which involves a protein kinase C. EMBO J. 15, 45264536.
  • Cowburn R. F., O'Neill C., Bonkale W. L., Ohm T. G. and Fastbom J. (2001) Receptor G protein signaling in Alzheimer's disease. Biochem. Soc. Symp. 67, 163175.
  • Craft S., Peskind E., Schwartz M. W., Schellenberg G. D., Raskind M. and Porte D. Jr (1998) Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: relationship to severity of dementia and apolipoprotein E genotype. Neurology 50, 164168.
  • Eickholt B. J., Walsh F. S. and Doherty P. (2002) An inactive pool of GSK-3 at the leading edge of growth cones is implicated in Semaphorin 3A signaling. J. Cell Biol. 157, 211217.
  • Elias M. F., Beiser A., Wolf P. A., Au R., White R. F. and D'Agostino R. B. (2000) The preclinical phase of alzheimer disease: a 22-year prospective study of the Framingham Cohort. Arch. Neurol. 57, 808813.
  • Favit C., Grimaldi M., Nelson T. J. and Alkon D. L. (1998) Alzheimer's-specific effects of soluble β-amyloid on protein kinase C-α and γ degradation in human fibroblasts. Proc. Natl Acad. Sci. USA 95, 55625567.
  • Franke T. F., Kaplan D. R., Cantley L. C. and Toker A. (1997) Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate. Science 275, 665668.
  • Frolich L., Blum-Degen D., Bernstein H. G., et al. (1998) Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease. J. Neural. Transm. 105, 423438.
  • Gasparini L., Netzer W. J., Greengard P. and Xu H. (2002) Does insulin dysfunction play a role in Alzheimer's disease? Trends Pharmacol. Sci. 23, 288293.
  • Georgopoulou N., McLaughlin M., McFarlane I. and Breen K. C. (2001) The role of post-translational modification in β-amyloid precursor protein processing. Biochem. Soc. Symp. 67, 2336.
  • Goode N., Hughes K., Woodgett J. R. and Parker P. J. (1992) Differential regulation of glycogen synthase kinase-3β by protein kinase C isotypes. J. Biol. Chem. 267, 1687816882.
  • Grimes C. A. and Jope R. S. (2001) The multifaceted roles of glycogen synthase kinase 3β in cellular signaling. Prog. Neurobiol. 65, 391426.
  • Grober E., Dickson D., Sliwinski M. J., Buschke H., Katz M., Crystal H. and Lipton R. B. (1999) Memory and mental status correlates of modified Braak staging. Neurobiol. Aging 20, 573579.
  • Grundke-Iqbal I., Iqbal K., Quinlan M., Tung Y. C., Zaidi M. S. and Wisniewski H. M. (1986a) Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. J. Biol. Chem. 261, 60846089.
  • Grundke-Iqbal I., Iqbal K., Tung Y. C., Quinlan M., Wisniewski H. M. and Binder L. I. (1986b) Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc. Natl Acad. Sci. USA 83, 49134917.
  • Hanger D. P., Betts J. C., Loviny T. L. F., Blackstock W. P. and Anderton B. H. (1998) New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry. J. Neurochem. 71, 24652476.
  • Hauss-Wegrzyniak B., Dobrzanski P., Stoehr J. D. and Wenk G. L. (1998) Chronic neuroinflammation in rats reproduces components of the neurobiology of Alzheimer's disease. Brain Res. 780, 294303.
  • Hernandez F., Borrell J., Guaza C., Avila J. and Lucas J. J. (2002) Spatial learning deficit in transgenic mice that conditionally over-express GSK-3β in the brain but do not form tau filaments. J. Neurochem. 83, 15291533.
  • Iqbal K., Grundke-Iqbal I., Smith A. J., George L., Tung Y. C. and Zaidi T. (1989) Identification and localization of a tau peptide to paired helical filaments of Alzheimer's disease. Proc. Natl Acad. Sci. USA 86, 56465650.
  • Ishiguro K., Takamatsu M., Tomizawa K., Omori A., Takahashi M., Arioka M., Uchida T. and Imahori K. (1992) Tau protein kinase I converts normal tau protein into A68-like component of paired helical filaments. J. Biol. Chem. 267, 1089710901.
  • Kandel E. R. (2000) Cellular mechanism of learning and the biological basis of individuality. In: Principles of Neural Science, 4th edn. (Kandel, E. R., Schwartz, J. H. and. Jessell, T. M., eds), pp. 12641267. McGraw-Hill Companies, Inc., New York.
  • Kauffmann-Zeh A., Rodriguez-Viciana P., Ulrich E., Gilbert C., Coffer P., Downward J. and Evan G. (1997) Suppression of c-Myc-induced apoptosis by Ras signaling through PI(3)K and PKB. Nature 385, 544548.
  • Kurumatani T., Fastbom J., Bonkale W. L., Bodganovic N., Winblad B., Ohm T. G. and Cowburn R. F. (1998) Loss of inositol 1,4,5-triphosphate receptor sites and decreased PKC levels correlate with staging of Alzheimer's disease neuorfibrillary pathology. Brain Res. 796, 209221.
  • Latimer D. A., Gallo J. M., Lovestone S., Miller C. C. J., Reynolds C. H., Marquardt B., Stabel S., Woodgett J. R. and Anderton B. H. (1995) Stimulation of MAP kinase by v-raf transfection of fibroblasts fails to induce hyperphosphorylation of transfected tau. FEBS Lett. 365, 4246.
  • Lee V. M., Balin B. J., Otvos L. Jr and Trojanowski J. Q. (1991) A68: a major subunit of paired helical filaments and derivatized forms of normal Tau. Science 251, 675678.
  • Leibson C. L., Rocca W. A., Hanson V. A., Cha R., Kokmen E., O'Brien P. C. and Palumbo P. J. (1997) Risk of dementia among persons with diabetes mellitus: a population-based cohort study. Am. J. Epidemiol. 145, 301308.
  • Leroy K., Boutajangout A., Authelet M., Woodgett J. R., Anderton B. H. and Brion J. P. (2002) The active form of glycogen synthase kinase-3β is associated with granulovacuolar degeneration in neurons in Alzheimer's disease. Acta Neuropathol. 103, 9199.
  • Liu S. J. and Wang J. Z. (2002) Alzheimer-like tau phosphorylation induced in vivo by wortmannin and its attenuation by melatonin. Acta Pharmacol. Sin. 23, 183187.
  • Lovestone S., Reynolds C. H., Latimer D. et al. (1994) Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells. Curr. Biol. 4, 10771086.
  • Lucas J. J., Hernandez F., Gomez-Ramos P., Moran M. A., Hen R. and Avila J. (2001) Decreased nuclear β-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3β conditional transgenic mice. EMBO J. 20, 2739.
  • Maccioni R. B. and Cambiazo V. (1995) Role of microtubule-associated proteins in the control of microtubule assembly. Physiol. Rev. 75, 835864.
  • McLaughlin M. and Breen K. C. (1999) Protein kinase C activation potentiates the rapid secretion of the amyloid precursor protein from rat cortical synaptosomes. J. Neurochem. 72, 273281.
  • Mandelkow E. M., Drewes G., Biernat J., Gustke N., Van Lint J., Vandenheede J. R. and Mandelkow E. (1992) Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau. FEBS. Lett. 314, 315321.
  • Mandelkow E. M., Biernat J., Drewes G., Gustke N., Trinczek B. and Mandelkow E. (1995) Tau domains, phosphorylation, and interactions with microtubules. Neurobiol. Aging 16, 355362; discussion 362–363.
  • Marambaud P., Lopez-Perez E., Wilk S. and Checler F. (1997) Constitutive and protein kinase C-regulated secretory cleavage of Alzheimer's disease β-amyloid precursor protein: different control of early and late events by the prorteasome. J. Neurochem. 69, 25002505.
  • Morishima-Kawashima M., Hasegawa M., Takio K., Suzuki M., Yoshida H., Watanabe A., Titani K. and Ihara Y. (1995) Hyperphosphorylation of tau in PHF. Neurobiol. Aging 16, 365371; discussion 371–380.
  • Morris R. (1984) Developments of a water-maze procedure for studying spatial learning in the rat. J. Neurosci. Methods 11, 4760.
  • Ott A., Stolk R. P., Hofman A., Van Harskamp F., Grobbee D. E. and Breteler M. M. (1996) Association of diabetes mellitus and dementia: the Rotterdam Study. Diabetologia. 39, 13921397.
  • Pei J. J., Tananka T., Tung Y. C., Braak E., Iqbal K. and Grundke-Iqbal I. (1997) Distribution, levels, and activity of glycogen synthase-3 in the Alzheimer's disease brain. J. Neuropathol. Exp. Neurol. 56, 7078.
  • Pei J. J., Braak E., Braak H., Grundke-Iqbal K., Iqbal K., Winblad B. and Cowburn R. F. (1999) Distribution of active glycogen synthase kinase 3β (GSK-3β) in brains staged for Alzheimer's disease neurofibrillary changes. J. Neuropathol. Exp. Neurol. 58, 10101019.
  • Phiel C. J., Wilson C. A., Lee V. M. and Klein P. S. (2003) GSK-3α regulates production of Alzheimer's disease amyloid-β peptides. Nature 423, 435439.
  • Reynolds C. H., Betts J. C., Blackstock W. P., Nebreda A. R. and Anderton B. H. (2000) Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: differences in vitro between the mitogen-activated protein kinases ERK2, c-jun N-terminal kinase and p38, and glycogen synthase kinase-3β. J. Neurochem. 74, 15871595.
  • Russ C., Lovestone S. and Powell J. F. (2001) Identification of sequence variants and analysis of the role of the glycogen synthase kinase 3β gene and promoter in late onset Alzheimer's disease. Mol. Psychiatry. 6, 320324.
  • Ryves W. J. and Harwood A. J. (2001) Lithium inhibits glycogen synthase kinase-3 by competition for magnesium. Biochem. Biophys. Res. Commun. 280, 720725.
  • Saragoni L., Hernandez P. and Maccioni R. B. (2000) Differential association of tau with subsets of microtubules containing post-translationally modified tubulin variants in neuroblastoma cells. Neurochem. Res. 25, 5970.
  • Shoghi-Jadid K., Small G. W., Agdeppa E. D. et al. (2002) Localization of neurofibrillary tangles and β-amyloid plaques in the brains of living patients with Alzheimer's disease. Am. J. Geriatr. Psychiatry 10, 2435.
  • Singh T. J., Haque N., Grundke-Iqbal I. and Iqbal K. (1995) Rapid Alzheimer-like phosphorylation of tau by the synergistic actions of non-proline-dependent protein kinases and GSK-3. FEBS Lett. 358, 267272.
  • Tang M. X., Jacobs D., Stern Y., Marder K., Schofield P., Gurland B., Andrews H. and Mayeux R. (1996) Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease. Lancet 348, 429432.
  • Toullecn D., Pianetti P., Coste H. et al. (1991) The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J. Biol. Chem. 266, 1577115781.
  • Tsujio I., Tanaka T., Kudo T., Nishikawa T., Shinozaki K., Grundke-Iqbal I., Iqbal K. and Takeda M. (2000) Inactivation of glycogen synthase kinase-3 by protein kinase Cδ: implications for regulation of tau phosphorylation. FEBS Lett. 469, 111117.
  • Yang S. D., Song J. S., Yu J. S. and Shiah S. G. (1993) Protein kinase FA/GSK-3 phosphorylates tau on Ser235-Pro and Ser404-Pro that are abnormally phosphorylated in Alzheimer's disease brain. J. Neurochem. 61, 17421747.
  • Yang S. D., Yu J. S., Shiah S. G. and Huang J. J. (1994) Protein kinase FA/glycogen synthase kinase-3α after heparin potentiation phosphorylates tau on sites abnormally phosphorylated in Alzheimer's disease brain. J. Neurochem. 63, 14161425.
  • Zhu G., Wang D., Liu Y. H., McMahon T., Koo E. H. and Messing R. O. (2001) Protein kinase Cζ suppresses Aβ production and promotes activation of α-secretase. Biochem. Biophys. Res. Commun. 285, 9971006.