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Indices of multilocus linkage disequilibrium
Article first published online: 11 APR 2005
DOI: 10.1046/j.1471-8278.2000.00014.x
1755-0998/asset/cover.gif?v=1&s=55f2aa548e40ab774d4dae4023982762bbc1391f "Molecular Ecology Notes")
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How to Cite
Agapow, P.-M. and Burt, A. (2001), Indices of multilocus linkage disequilibrium. Molecular Ecology Notes, 1: 101–102. doi: 10.1046/j.1471-8278.2000.00014.x
Publication History
- Issue published online: 11 APR 2005
- Article first published online: 11 APR 2005
- Received 5 October 2000; revision accepted 9 November 2000
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Keywords:
- correlation coefficient;
- index of association;
- linkage disequilibrium;
- missing data;
- MultiLocus;
- randomization
Abstract
Linkage disequilibrium is an ubiquitous biological phenomenon. However a common metric for disequilibrium – the index of association or IA– is dependent on sample size. In this paper we present a modification of IA that removes this dependency. This method has been implemented in a software package.