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Indices of multilocus linkage disequilibrium


Paul-Michael Agapow. Fax: + 44 (0) 207 594 2339; E-mail:


Linkage disequilibrium is an ubiquitous biological phenomenon. However a common metric for disequilibrium – the index of association or IA– is dependent on sample size. In this paper we present a modification of IA that removes this dependency. This method has been implemented in a software package.