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Microsatellite loci in the human blood fluke Schistosoma mansoni and their utility for other schistosome species


Jason Curtis.


Blood flukes in the genus Schistosoma are important human parasites in tropical regions. Genetic heterogeneity of the parasite contributes to the observed phenotypic variation in this host–parasite interaction and may play a role in disease epidemiology. In this paper, we describe the characterization of five polymorphic microsatellite loci from the human blood fluke Schistosoma mansoni, which can now be applied in assessments of schistosome genetic diversity. The five loci revealed extensive polymorphism, as 5–8 alleles per locus were detected among five isolates (from both human patients and snail intermediate hosts) from two Brazilian villages.