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Production of γ-linolenic acid by Mortierella isabellina grown on hexadecanol

  1. M. Xian1,
  2. J. Yan2,
  3. Y. Kang3,
  4. J. Liu3,
  5. Y. Bi1,
  6. K. Zhen1

Article first published online: 7 JUL 2008

DOI: 10.1046/j.1472-765X.2001.00924.x

Issue

Letters in Applied Microbiology

Letters in Applied Microbiology

Volume 33, Issue 5, pages 367–370, November 2001

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How to Cite

Xian, M. , Yan, J. , Kang, Y. , Liu, J. , Bi, Y. and Zhen, K. (2001), Production of γ-linolenic acid by Mortierella isabellina grown on hexadecanol. Letters in Applied Microbiology, 33: 367–370. doi: 10.1046/j.1472-765X.2001.00924.x

Author Information

  1. 1

    Department of Chemistry, Jilin University, Changchun 130023, China

  2. 2

    Department of Chemistry, North-east Normal University, Changchun 130024, China

  3. 3

    Department of Applied Chemistry, Qingdao Institute of Chemical Technology, Qingdao 266042, China

* Dr Mo Xian, Department of Chemistry, Jilin University, Jiefang Road 119#, Changchun130023, China (e-mail: ctx@mail.jlu.edu.cn).

Publication History

  1. Issue published online: 7 JUL 2008
  2. Article first published online: 7 JUL 2008

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Aims: To optimize the production of linolenic acid by Mortierella isabellina grown on hexadecanol.

Methods and Results: Effects of culture conditions such as culture time, pH of medium, hexadecanol concentration, incubation temperature and ageing of mycelia on production of linolenic acid were studied. The production of γ-linolenic acid reached 2·44 mg ml−1 (271 mg g−1 dry cells) when Mortierella isabellina was cultivated in a medium consisting of 2% hexadecanol and 1% yeast extract at 23°C for 120 h and then the mycelia, after removal of medium by suction filtration, were allowed to stand for a further 15 d at 5°C.

Conclusions: Ageing of mycelia and incubation temperature showed predominant effects on the increased linolenic acid production.

Significance and Impact of the Study: This study highlights effective conditions for increasing linolenic acid production by Mortierella isabellina grown on hexadecanol.

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