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Keywords:

  • antimalarial drug combinations;
  • chemoresistance;
  • falciparum malaria

Abstract

Malaria is a leading cause of morbidity and mortality in developing countries. Selection of mutant Plasmodium falciparum malaria strains under drug pressure has led to the development of drug resistance. There is a pressing need for effective, safe, practicable drug combinations that hve lower selection pressure. A review of the mein drug combinations, which are recently registered or are still under development, was undertaken, with special attention to the atovaquone–proguanil and artemether–lumefantrine combination.