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Realizing the cosmetic potential of topical photodynamic therapy

Authors

  • C A Morton

    Corresponding author
    1. Department of Dermatology, Falkirk Royal Infirmary, Falkirk, UK
      Dr Colin A Morton, Department of Dermatology, Falkirk Royal Infirmary, Major's Loan, Falkirk, FK1 5QE, UK. Tel.: 0 (44) 1324 624 000; Fax: 0 (44) 1324 678 566: E-mail: colin.morton@fvah.scot.nhs.uk
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Dr Colin A Morton, Department of Dermatology, Falkirk Royal Infirmary, Major's Loan, Falkirk, FK1 5QE, UK. Tel.: 0 (44) 1324 624 000; Fax: 0 (44) 1324 678 566: E-mail: colin.morton@fvah.scot.nhs.uk

Abstract

Summary Several open studies report the efficacy of topical photodynamic therapy (PDT) for non-melanoma skin cancer (NMSC) and precursor lesions. PDT may also be effective in various inflammatory and infectious dermatoses. As a tissue sparing modality, PDT may be preferable for large and/or multiple lesions and those in sites where disfigurement or poor healing from conventional therapies is a particular risk. Limited comparison data confirms that topical PDT achieves superior cosmesis to conventional therapies in actinic keratoses, squamous cell carcinoma in-situ and basal cell carcinoma. This review assesses the current data and proposes potential future applications for topical PDT including the treatment of photo-damaged skin.

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