Ironing out Parkinson's disease: is therapeutic treatment with iron chelators a real possibility?
Article first published online: 15 SEP 2002
Volume 1, Issue 1, pages 17–21, October 2002
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How to Cite
Kaur, D. and Andersen, J. K. (2002), Ironing out Parkinson's disease: is therapeutic treatment with iron chelators a real possibility?. Aging Cell, 1: 17–21. doi: 10.1046/j.1474-9728.2002.00001.x
- Issue published online: 15 SEP 2002
- Article first published online: 15 SEP 2002
- Accepted for publication 18 June 2002
- iron chelators;
- oxidative stress;
- Parkinson's disease;
Levels of iron are increased in the brains of Parkinson's disease (PD) patients compared to age-matched controls. This has been postulated to contribute to progression of the disease via several mechanisms including exacerbation of oxidative stress, initiation of inflammatory responses and triggering of Lewy body formation. In this minireview, we examine the putative role of iron in PD and its pharmacological chelation as a prospective therapeutic for the disease.