• Open Access

Oxidative stress in Caenorhabditis elegans: protective effects of superoxide dismutase/catalase mimetics

Authors



Dr Gordon J. Lithgow, The Buck Institute, 8001 Redwood Boulevard, Novato, CA 94945, USA. Tel.: +1 415209 2094; fax: +1 415209 2232; e-mail: glithgow@buckinstitute.org

Summary

The lifespan of Caenorhabditis elegans can be extended by the administration of synthetic superoxide dismutase/catalase mimetics (SCMs) without any effects on development or fertility. Here we demonstrate that the mimetics, Euk-134 and Euk-8, confer resistance to the oxidative stress-inducing agent, paraquat and to thermal stress. The protective effects of the compounds are apparent with treatments either during development or during adulthood and are independent of an insulin/IGF-I-like signalling pathway also known to affect thermal and oxidative stress resistance. Worms exposed to the compounds do not induce a cellular stress response and no detrimental effects are observed.

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