Mitochondria and aging: a role for the permeability transition?
Article first published online: 15 DEC 2003
Volume 3, Issue 1, pages 3–6, February 2004
How to Cite
Crompton, M. (2004), Mitochondria and aging: a role for the permeability transition?. Aging Cell, 3: 3–6. doi: 10.1046/j.1474-9728.2003.00073.x
- Issue published online: 15 DEC 2003
- Article first published online: 15 DEC 2003
- Accepted for publication 10 November 2003
- adenine nucleotide translocase;
- membrane potential;
- oxidative stress;
- permeability transition
When mitochondria are subjected to oxidative stress and relatively high [Ca2+], they undergo a ‘permeability transition’ in which the inner membrane becomes freely permeable to low-molecular-weight solutes. This phenomenon reflects reversible deformation of the adenine nucleotide translocase, the loss of its native gating properties and the stabilization of the deformed state by cyclophilin-D. The permeability transition may be a factor in cell dysfunction associated with aging. This can manifest in a number of ways ranging, in the most severe, from impaired energy transduction and compromised viability to more subtle influences on the propagation of Ca2+ signals. This article critically examines data relevant to this issue.