The Pulfrich effect can occur spontaneously, giving severe symptoms of changed visual perception in a variety of conditions in which an interocular latency difference has occurred. The symptoms principally involve misjudgements on the location of objects, especially when driving. Interocular latency differences can inadvertently be created in patients in practice and this study has investigated the Pulfrich effect in anisocoria, uniocular mydriasis, and with uniocular tint (X-chrom lens). In all cases a Pulfrich effect was consistently evident and compared to the size of the effect provoked by neutral density filters. The results show that with anisocoria, uniocular mydriasis and the X-chrom lens, the provoked Pulfrich effect is similar to that found reported previously in cases of trauma. These cases had severe visual symptoms so that care should be exercised in practice, where procedures likely to provoke the Pulfrich effect are contemplated. Specifically, patients who have received uniocular mydriasis in practice should be cautioned about the possible visual effects and advised not to drive until the effect of the mydriatic has finished and equal pupil sizes have been restored.