Amblyopia: a tale of two approaches



Our understanding of the physiological basis for amblyopia in humans has undergone dramatic changes over the past two decades. The first such change occurred when we were first able to record from single neurones in different parts of the visual pathway and develop neural models of the anomaly. The second came from psychophysical investigations and evaluations of these animal models. Our understanding has progressed from one focused on the properties of single cortical cells to an appreciation of the anomalous behaviour of cellular networks.