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Background. Various alloplastic injectable implants have been developed for soft tissue augmentation without surgery, but different local or systemic adverse reactions have limited their use for cosmetic purposes.

Objective. To examine the problems associated with silicone injection.

Methods. Case report and literature review.

Results. We describe an adverse granulomatous reaction after the injection of liquid silicone for lip augmentation, causing facial disfigurement. Although the initial response to steroids was poor, after 3 years of follow-up the nodules have almost disappeared spontaneously.

Conclusion. We advise that silicone injection be performed solely by trained physicians using medical-grade silicone or consider other injectable materials.