E.F. Bernstein, MD, J. Lee, MD, and D.B. Brown, MS have indicated no significant interest with commercial supporters. R. Yu, PhD, OMD and E. Van Scott, MD have a financial interest in NeoStrata Co., Inc., Princeton, NJ.
Glycolic Acid Treatment Increases Type I Collagen mRNA and Hyaluronic Acid Content of Human Skin
Article first published online: 20 DEC 2001
Volume 27, Issue 5, pages 429–433, May 2001
How to Cite
Bernstein, E. F., Lee, J., Brown, D. B., Yu, R. and Van Scott, E. (2001), Glycolic Acid Treatment Increases Type I Collagen mRNA and Hyaluronic Acid Content of Human Skin. Dermatologic Surgery, 27: 429–433. doi: 10.1046/j.1524-4725.2001.00234.x
- Issue published online: 20 DEC 2001
- Article first published online: 20 DEC 2001
Background. Chronic solar irradiation results in both morphologic and functional changes in affected skin. α-hydroxy acids, such as glycolic acid, have been shown to improve photodamaged skin.
Objective. To investigate alterations in collagen gene induction and epidermal and dermal hyaluronic acid production as a result of administered glycolic acid.
Methods. In this study we compared collagen gene expression from skin biopsy specimens, and epidermal and dermal hyaluronic acid immunohistochemical staining between glycolic acid-treated and vehicle-treated skin. Forearm skin was treated with 20% glycolic acid lotion or a lotion vehicle control twice a day for 3 months.
Results. Epidermal and dermal hyaluronic acid and collagen gene expression were all increased in glycolic acid-treated skin as compared to vehicle-treated controls.
Conclusion. Our data suggest that epidermal and dermal remodeling of the extracellular matrix results from glycolic acid treatment. Longer treatment intervals may result in collagen deposition as suggested by the measured increase in mRNA.