Human Anti-Hyaluronic Acid Antibodies: Is it Possible?


  • P. Micheels, MD has indicated no significant interest with commercial supporters.

Address correspondence and reprint requests to: Patrick Micheels, MD, 58, Rue de la Terrassiere, 1207 Geneva, Switzerland.


Background. Although hyaluronan has been acknowledged as being free of species and organ specificity, for 4 years I have encountered a variety of adverse reactions to injectable hyaluronic acid as used in aesthetic medicine.

Objective. I have tried to prove that some of those side effects may be allergic reactions to the commercial preparations of injectable hyaluronic acid.

Methods. I began with intradermal tests to the reactive patients and to 2 witnesses; then lymphocyte transforming tests were performed at the University of Geneva (Switzerland). Histology was performed on the skin tests and on reactive treated areas of the face of different patients. A serum analysis was then done by Pr. Sainte Laudy of Laboratoire Pasteur—Cerba (France).

Results. The skin tests were positive for one or the other or both of the injectable hyaluronic acid preparations used in aesthetic medicine. The different biopsies have shown for some a chronic inflammatory reaction, even 11 months after the treatment or a severe granulamatous reaction to foreign bodies. Serum analysis revealed positive antibodies against Restylane and/or Hylaform and even IgG and E anti-hyaluronic acid.

Conclusion. Since 1995, I have 8 patients with adverse reactions to injectable hyaluronic acid, which after several tests, may be allergic to those products. Isn't it time to introduce intradermal tests before any injection of this type, as done with injectable bovine collagen?