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Background. In vitiligo universalis, repigmentation therapy is seldom effective. Besides, bleaching cream which is often used in depigmentation therapy may lead to several serious complications.

Objective. Q-switched (QS) ruby laser can destroy melanosomes in melanocytes and keratinocytes by selective photothermolysis.

Methods. We have attempted to destroy melanocytes by using the QS ruby laser after tanning in a patient with extensive vitiligo.

Results. The patient had excellent results with no evidence of repigmentation after 1 year.

Conclusion. Depigmentation therapy with QS ruby laser after tanning is an effective and safe way of removing remnants of normal pigmentation in patients with vitiligo universalis.