Prognostic Factors and Local Recurrence in Patients with Ductal Carcinoma In Situ of the Breast


Address correspondence and reprint requests to: Melvin J. Silverstein, MD, USC–Norris Cancer Center, 1441 Eastlake Ave., Room 7415 A, Los Angeles, CA 90033, U.S.A.


Abstract: Local recurrence is an important event when it occurs in a patient previously treated for ductal carcinoma in situ. Therefore, the ability to predict the probability of local recurrence after breast preservation therapy would be extremely valuable in the treatment decision-making process. In an attempt to predict the likelihood of local recurrence, 30 prognostic factors were evaluated in 622 patients with ductal carcinoma in situ treated at the Van Nuys Breast Center from 1979 through June 1996. Four factors emerged as significant independent predictors of local recurrence. These included treatment, tumor size, margin width, and pathologic classification.