Breast Carcinomas With Choriocarcinomatous Features: Case Reports and Review of the Literature


Address correspondence and reprint requests to: Yildiz Erhan, MD, Ege Universitesi Týp Fakültesi Patoloji Anabilim Dalý, 35100 Bornova, Izmir, Turkey.


Breast cancer with choriocarcinomatous features is rare. This report describes four cases of breast cancer with choriocarcinomatous features. The tumor cells were positive for human placental lactogen (hPL) and human chorionic gonadotropin (hCG) by immunohistochemistry. The cases reported in the literature had a poor prognosis and the patients died within a few months after the diagnosis. In this series, two cases were lost to follow-up, but the other two have had disease-free survival for 2 and 4 years, respectively.