Pattern of CIN recurrence following laser ablation treatment: long-term follow-up
Article first published online: 25 DEC 2001
International Journal of Gynecological Cancer
Volume 9, Issue 6, pages 487–490, November 1999
How to Cite
Chew, G. K., Jandial, L., Paraskevaidis, E. and Kitchener, H. C. (1999), Pattern of CIN recurrence following laser ablation treatment: long-term follow-up. International Journal of Gynecological Cancer, 9: 487–490. doi: 10.1046/j.1525-1438.1999.99066.x
- Issue published online: 25 DEC 2001
- Article first published online: 25 DEC 2001
- Accepted for publication September 24, 1999.
Abstract. Chew GK, Jandial L, Paraskevaidis E, Kitchener HC. Pattern of CIN recurrence following laser ablation treatment: Long-term follow-up.
Our objective was to study the long-term patern of recurrence of cervical intraepithelial neoplasia (CIN) and development of cervical carcinoma in patients who had been treated with laser ablative treatment. The study design consisted of a retrospective analysis of the case records of 2130 patients who received laser ablation treatment for CIN lesions from 1980–1988, with the years 1980 and 1988 inclusive. All of the 2130 women in the cohort have had at least seven years of follow-up. Of the treated population, 79% remain under regular cytological follow-up at the regional laboratory. Nine percent required further treatment, 52% of this within the first year of treatment, 19% within the second year, 4% in the third, 5% in the fourth and fifth years, and 15% over the next five years. These lesions were detected up to ten years after the initial treatment. No recurrent lesions have yet been detected after ten years, and 0.2% of the cohort have developed cervical carcinoma. Long-term follow-up has demonstrated a continuing incidence of recurrent CIN up to ten years after initial treatment. This emphasizes the need for adherence to follow-up protocol if the incidence of cervical carcinoma post-treatment is to be reduced. The data suggest that annual follow-up for 10 years may be advisable to reduce the risk of post-treatment invasive disease.