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Junctional Epidermolysis Bullosa with Pyloric Stenosis Presenting with Electron Microscopic Findings Suggestive of Epidermolysis Bullosa Simplex

Authors


Address correspondence to Andrew N. Lin, M.D., Division of Dermatology and Cutaneous Sciences, 2-105 Clinical Sciences Building, University of Alberta, Edmonton, Alberta, Canada T6G 2G3, or e-mail: anlin@maildrop.srv.ualberta.ca.

Abstract

Abstract: We present an infant girl who was born with pyloric stenosis and epidermolysis bullosa (EB). Electron microscopy of a skin biopsy specimen showed findings suggestive of EB simplex, but immunofluorescence (IF) mapping of the same specimen established the diagnosis of junctional EB. Because electron microscopy findings may sometimes be misleading, an EB patient with pyloric stenosis and electron microscopy findings suggestive of EB simplex should have a biopsy specimen examined by immunofluorescence mapping, which may confirm that the patient in fact has junctional EB.

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