Transient Beneficial Effect of GH Replacement Therapy and Topical GH Application on Skin Ulcers in a Boy with Prolidase Deficiency


Address correspondence to Virginia Monafo, M.D., Department of Pediatric Sciences, IRCCS Policlinico San Matteo, University of Pavia, P.le Golgi 2, 27100 Pavia, Italy, or e-mail:


Abstract: A diagnostic examination for short stature in a boy with chronic ulcers of the feet due to prolidase deficiency, a rare disorder associated with intractable ulcers of the skin, led to the diagnosis of growth hormone (GH) deficiency. Replacement treatment with r-hGH associated with the topical application of a GH-containing ointment when the boy was 13 years old resulted in complete but transitory healing of the ulcers, which can probably be attributed to the growth-promoting effects of GH on dermal connective tissue.