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Minocycline Hypersensitivity Syndrome with Hypotension Mimicking Septic Shock


Anita P. Sheth M.D. Department of Dermatology, OSB-5, Children’s Hospital Medical Center, 3333 Burnet Ave., Cincinnati, OH 45229-3039.


Minocycline is a semisynthetic tetracycline derivative that is often used in the treatment of acne vulgaris. A serious but rare adverse effect caused by minocycline therapy is a hypersensitivity syndrome (HS), consisting of fever, skin eruption, and internal organ involvement that begins within 8 weeks of therapy initiation. We report a case of minocycline HS with unique features, namely, associated hypotension, and a rebound of the cutaneous eruption upon discontinuation of systemic steroids.