Waxy Keratoses of Childhood in a Segmental Distribution


Neil S. Prose M.D. Department of Dermatology, Duke University Medical Center, Box 3252, Durham, NC 27710, or e-mail: prose001@mc.duke.edu.


Waxy keratoses of childhood is a rare genodermatosis previously noted in both familial and isolated presentations. Three previous cases have been described in which the lesions appeared over the trunk and extremities. We report a case in which the waxy keratoses of childhood lesions appeared in a segmental distribution along a single lower extremity, differing from the more extensive patterns reported previously. We suggest a possible postzygotic mutation hypothesis for this unique segmental distribution, addressing both the possibility of a genomic mosaicism and loss of heterozygosity.