1525-1594/asset/aor_centre.gif?v=1&s=bf5cf6c2ae31ef6442b2fd393bf5814abbc9d371)
Effects of New Polymer-Coated Extracorporeal Circuits on Biocompatibility During Cardiopulmonary Bypass
Article first published online: 24 DEC 2001
DOI: 10.1046/j.1525-1594.2000.06520.x
1525-1594/asset/cover.gif?v=1&s=5d42e340ac43b5209a579a5a2468a367ae41c522 "Artificial Organs")
Additional Information
How to Cite
Saito, N., Motoyama, S. and Sawamoto, J. (2000), Effects of New Polymer-Coated Extracorporeal Circuits on Biocompatibility During Cardiopulmonary Bypass. Artificial Organs, 24: 547–554. doi: 10.1046/j.1525-1594.2000.06520.x
Publication History
- Issue published online: 24 DEC 2001
- Article first published online: 24 DEC 2001
- Received August 1999; revised January 2000.
- Abstract
- Cited By
Keywords:
- Cardiopulmonary bypass;
- Bradykinin;
- Complement;
- CD35;
- CD14;
- Protein adsorption
Abstract: An inflammatory response due to bioincompatibility of extracorporeal circuits is a major clinical issue during cardiopulmonary bypass (CPB). By using a swine model, we determined whether new polymer-coated circuits, the blood-contacting surfaces of which are coated with poly(2-methoxyethylacrylate) (PMEA), would reduce the inflammatory response during CPB. Plasma bradykinin levels and the percentages of CD35-positive monocytes in PMEA-coated circuits were significantly lower than those in uncoated circuits during CPB. The amount of proteins adsorbed on the PMEA-coated circuits was significantly lower than that on the uncoated circuits (0.30 μg/cm2 versus 3.42 μg/ cm2). Almost no IgG, IgM, or C3c/d was detected in proteins adsorbed on the PMEA-coated circuits although these proteins were clearly detected in proteins adsorbed on the uncoated circuits. We concluded that PMEA coating could reduce complement activation during CPB by suppressing the adsorption of IgG and IgM, which activate C3 via the classical pathway, on the surface of the circuits.