The Effect of Combination Therapy with Interferon and Cryofiltration on Mesangial Proliferative Glomerulonephritis Originating from Mixed Cryoglobulinemia in Chronic Hepatitis C Virus Infection
Article first published online: 5 JAN 2002
Volume 3, Issue 4, pages 329–333, November 1999
How to Cite
Kiyomoto, H., Hitomi, H., Hosotani, Y., Hashimoto, M., Uchida, K., Kurokouchi, K., Nagai, M., Takahashi, N., Fukunaga, M., Mizushige, K., Matsuo, H. and Yuasa, S. (1999), The Effect of Combination Therapy with Interferon and Cryofiltration on Mesangial Proliferative Glomerulonephritis Originating from Mixed Cryoglobulinemia in Chronic Hepatitis C Virus Infection. Therapeutic Apheresis, 3: 329–333. doi: 10.1046/j.1526-0968.1999.00196.x
- Issue published online: 5 JAN 2002
- Article first published online: 5 JAN 2002
- Received July 1999.
- Hepatitis C virus;
- Membranoproliferative glomerulonephritis;
Abstract: Cryofiltration, which has developed from double filtration plasmapheresis (DFPP) with a cooling unit, is an on-line technique to remove cryoglobulin. We report on a patient who suffered from progressive edema and renal insufficiency caused by cryoglobulinemic membranoproliferative glomerulonephritis (MPGN), probably due to chronic hepatitis C virus (HCV) infection. To remove cryoglobulins and terminate the HCV infection, we utilized combination therapy with cryofiltration and interferon-α injection with corticosteroids. Interferon-α was capable of decreasing proteinuria but not diminishing cryoglobulin. Additional cryofiltration could remove cryoglobulin to an undetectable level. This combination therapy was partially successful to reduce proteinuria and prevent the progressive deterioration of renal function. The major adverse effects of this therapy were bleeding and myelosuppression. We conclude that this combination therapy may be effective and should be considered as treatment for cryoglobulinemic MPGN.