Current Topics on Cytokine Removal Technologies
Article first published online: 13 JAN 2002
Volume 5, Issue 4, pages 306–314, August 2001
How to Cite
Matsuda, K., Hirasawa, H., Oda, S., Shiga, H. and Nakanishi, K. (2001), Current Topics on Cytokine Removal Technologies. Therapeutic Apheresis, 5: 306–314. doi: 10.1046/j.1526-0968.2001.00361.x
- Issue published online: 13 JAN 2002
- Article first published online: 13 JAN 2002
- Received April 2001.
- Continuous renal replacement therapy;
- Cytokine removal technology;
- Plasma exchange;
Abstract: It has been widely accepted that cytokines play important roles in the development of organ failure in various pathophysiological conditions of critically ill patients. Various new technologies, including continuous renal replacement therapy, have been developed for the removal of causative humoral mediators in sepsis or other critical conditions. Nonselective blood purification technologies, such as hemofiltration and plasma exchange, are applied in cytokine removal technology. However, the more selective blood purification technologies, such as adsorption, and the combination of those technologies, should be considered in future applications. Only through a prospective randomized controlled study can it be elucidated whether or not these technologies have efficacy in the treatment of sepsis and critically ill patients with hypercytokinemia. We should join and discuss the design of future clinical trials with a standardized strategy for the evaluation of the technologies.