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The Effect of Sumatriptan on Brain Monoamines in Rats


Dr. Dimos-Dimitrios Mitsikostas, Athens Naval Hospital, Department of Neurology, 70 Dinokratous Street, Athens 115 21, Greece.


Clinical data suggests that sumatriptan is effective in the acute treatment of migraine. The vascular sumatriptan on brain monoamines has not previously been investigated. In order to study these and 0.9 mg/kg of body weight), and 30 minutes later, all animals were decapitated Dopamine, serotonin, concentrations were measured in the frontal cortex, hypothalamus, striatum, and hippocampus, by high performance liquid chromatography. Plasm group was treated with NaCl 0.9%, given subcutaneously.

Sumatriptan, at the dose of 0.3 mg/kg did not alter the brain monoamine concentrations; however, at the turnover of dopamine and serotonin in the hypothalamus and striatum, while at the dose of 0.9 mg/kg, found. This subcortical antidopaminergic and antiserotoninergic effect of sumatriptan may be involved in its antimigraine action.