Severe Barbiturate Withdrawal Syndrome in Migrainous Patients


Dr. Michele Raja, Dipartimento di Salute Mentale, Ospedale Santo Spirito, Santo Spirito, 3, CAP 00193, Roma, Italy.


Three patients who presented with grand real seizures and an associated behavioral disorder were recognized as suffering from a severe butalbital withdrawal syndrome. All were migraineurs who had become dependent on barbiturates. We propose that the occurrence of seizures, psychotic behavior, or a recent personality change should be considered clues to possible barbiturate abuse in patients with migraine.