• migraine;
  • prophylaxis;
  • alpha1-adrenergic;
  • terazosin;
  • doxazosin

On the basis of the author’s personal experience with migraine, and occasional reports in the literature suggesting that alpha1-adrenergic blocking drugs may have a beneficial effect in the prophylaxis of migraine, 10 patients with migraine in a general neurology practice were placed on either terazosin or doxazosin. A decrease in migraine frequency or severity or both was seen in all but I patient, but 5 patients discontinued the drug due to side effects. No serious adverse reactions were reported. This anecdotal experience with the alpha 1 -adrenergic blockers warrants a controlled, double-blind study of this class of drugs for the prophylaxis of migraine.