Cerebral Vasomotor Changes in the Transient Syndrome of Headache With Neurologic Deficits and CSF Lymphocytosis (HaNDL)


Dr. Helmuth Steinmetz, Department of Neurology, Heinrich Heine University Duseldorf, Moorenstr. 5, D40225 Dusseldorf, Germany.


We report two patients with the recently described transient syndrome of headache with neurologic deficits and CSF lymphocytosis (HaNDL). Transcranial Doppler sonography performed during and after attacks of HaNDL showed asymmetrical decreases or increases in blood flow velocity of the middle cerebral artery, accompanied by increases or decreases in pulsatility suggesting fluctuations of arteriolar tone. The findings demonstrate focal vasomotor disturbances that link the transient headaches and deficits of HaNDL with attacks of migraine.