Transdermal Clonidine in the Prophylaxis of Episodic Cluster Headache: An Open Study

Authors


Dr. Gennaro Bussone, Istituto Neurologico Carlo Baste, via Calorie 11, 20133 Milano, Italy

Abstract

Transdermal clonidine has recently been reported to be efficacious in the prophylaxis of cluster headache. A 2-week course of transdermal clonidine (5 mg the first week, 7.5 mg the second week) prceded by a 5-day run-in period, was administered to 16 patients with episodic cluster headache in an active cluster period. In 5 patients, the painful attacks. disappeared after the seventh day of treatment. For the group as a whole, no significant variations in headache frequency. pain intensity, or attack duration were observed between the run-in period and the first and second weeks of treatment (ANOVA). Further studies are necessary to clarify the effectiveness of transdermal clonidine in the prophylaxis of episodic cluster headache.

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